Journal article
Apolipoprotein A1 Protects Against Necrotic Core Development in Atherosclerotic Plaques: PDZK1-Dependent HDL (High-Density Lipoprotein) Suppression of Necroptosis in Macrophages
Abstract
BACKGROUND: Atherosclerosis is a chronic disease affecting artery wall and a major contributor to cardiovascular diseases. Large necrotic cores increase risk of plaque rupture leading to thrombus formation. Necrotic cores are rich in debris from dead macrophages. Programmed necrosis (necroptosis) contributes to necrotic core formation. HDL (high-density lipoprotein) exerts direct atheroprotective effects on different cells within …
Authors
Kluck GEG; Qian AS; Sakarya EH; Quach H; Deng YD; Trigatti BL
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 43, No. 1, pp. 45–63
Publisher
Wolters Kluwer
Publication Date
1 2023
DOI
10.1161/atvbaha.122.318062
ISSN
1079-5642