Journal article
High density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation, through SR-B1, PI3K, and AKT1 and 2
Abstract
The cardioprotective lipoprotein HDL (high-density lipoprotein) prevents myocardial infarction and cardiomyocyte death due to ischemia/reperfusion injury. The scavenger receptor class B, type 1 (SR-B1) is a high-affinity HDL receptor and has been shown to mediate HDL-dependent lipid transport as well as signaling in a variety of different cell types. The contribution of SR-B1 in cardiomyocytes to the protective effects of HDL on cardiomyocyte …
Authors
Durham KK; Chathely KM; Trigatti BL
Journal
Biochemical Journal, Vol. 475, No. 7,
Publisher
Portland Press
Publication Date
April 16, 2018
DOI
10.1042/bcj20170703
ISSN
0264-6021