Journal article
Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo
Abstract
BACKGROUND: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum membranes (MAMs). The roles of Fundc1 and MAMs in diabetic hearts remain unknown. The aims of this study, therefore, were to determine whether the diabetes mellitus-induced Fundc1 expression could increase MAM formation, and whether disruption of MAM formation improves diabetic …
Authors
Wu S; Lu Q; Ding Y; Wu Y; Qiu Y; Wang P; Mao X; Huang K; Xie Z; Zou M-H
Journal
Circulation, Vol. 139, No. 16, pp. 1913–1936
Publisher
Wolters Kluwer
Publication Date
April 16, 2019
DOI
10.1161/circulationaha.118.033552
ISSN
0009-7322
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AMP-Activated Protein KinasesAdultAgedAnimalsCalcium SignalingCell LineDiabetic CardiomyopathiesEndoplasmic ReticulumFemaleGene Expression RegulationHumansMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMiddle AgedMitochondriaMitochondrial MembranesMitochondrial ProteinsMyocardial ContractionMyocytes, CardiacRats