Research Design Concept

subject area of

• 'Functional status of extremely preterm infants at kindergarten entry'.  Academic Article
• A CONTROLLED PROSPECTIVE STUDY OF THE EFFECT OF ENDURANCE TRAINING ON THE RECURRENCE RATE OF MYOCARDIAL INFARCTION  Academic Article
• A CTSA Agenda to Advance Methods for Comparative Effectiveness Research  Academic Article
• A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial  Academic Article
• A Checklist for Reporting Valuation Studies of Multi-Attribute Utility-Based Instruments (CREATE)  Academic Article
• A Comparison of Methods for Capturing Patient Preferences for Delivery of Mental Health Services to Low-Income Hispanics Engaged in Primary Care  Academic Article
• A Consumer's Guide to Subgroup Analyses  Academic Article
• A Critical Analysis of Studies of State Drug Reimbursement Policies: Research in Need of Discipline  Academic Article
• A Meta-Analytic Review of the Effect of Exercise on Smoking Cessation  Academic Article
• A Method for Identifying Research Priorities for Health Systems Research on Health and Aging  Academic Article
• A Pilot Feasibility Study of an Extension of the Acquaintanceship Recruitment Procedure in Recent-Onset Psychosis  Academic Article
• A Practical Guide to Research: Design, Execution, and Publication  Academic Article
• A Process for Systematically Reviewing the Literature: Providing the Research Evidence for Public Health Nursing Interventions  Academic Article
• A Prospective Comparison of Four Study Designs Used in Assessing Safety and Effectiveness of Drug Therapy in Hypertension Management  Academic Article
• A Rapid Method to Score Stream Reaches Based on the Overall Performance of Their Main Ecological Functions  Academic Article
• A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials of DHEA Treatment Effects on Quality of Life in Women with Adrenal Insufficiency  Academic Article
• A Systematic Review of Heparin to Treat Burn Injury  Academic Article
• A Systematic Review of Interventions for Elder Abuse  Academic Article
• A Systematic Review of the Quality of Trials Evaluating Biomedical HIV Prevention Interventions Shows That Many Lack Power  Academic Article
• A comparison of a new multinomial stopping rule with stopping rules of fleming and gehan in single arm phase II cancer clinical trials  Academic Article
• A comparison of dabigatran etexilate with warfarin in patients with mechanical heart valves: The Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt (RE-ALIGN)  Academic Article
• A comparison of meta-analytic methods for synthesizing evidence from explanatory and pragmatic trials  Academic Article
• A controlled trial of teaching critical appraisal of the clinical literature to medical students.  Academic Article
• A critical appraisal of bleeding events reported in venous thromboembolism prevention trials of patients undergoing hip and knee arthroplasty  Academic Article
• A critical review of the relationship between impaired fibrinolysis and myocardial infarction  Academic Article
• A double-blind, randomized controlled trial to compare the effect of biannual peripheral magnetic resonance imaging, radiography and standard of care disease progression monitoring on pharmacotherapeutic escalation in rheumatoid and undifferentiated inflammatory arthritis: study protocol for a randomized controlled trial  Academic Article
• A framework of operating models for interdisciplinary research programs in clinical service organizations  Academic Article
• A guide for the performance of the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase gene mutation assay  Academic Article
• A guide to interpreting discordant systematic reviews.  Academic Article
• A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): a study protocol (vol 2, 113, 2013)  Academic Article
• A multi-centre clinical evaluation of isoflurane  Academic Article
• A multi-centre randomised trial to compare the effectiveness of geriatrician-led admission avoidance hospital at home versus inpatient admission  Academic Article
• A new 'Mechanistic-Practical” Framework for designing and interpreting randomized trials  Academic Article
• A new era in idiopathic pulmonary fibrosis: considerations for future clinical trials  Academic Article
• A patient decision aid for antidepressant use in pregnancy: study protocol for a randomized controlled trial  Academic Article
• A phase II multi-institutional study assessing simultaneous in-field boost helical tomotherapy for 1-3 brain metastases  Academic Article
• A picture is worth a thousand words: maps of HIV indicators to inform research, programs, and policy from NA-ACCORD and CCASAnet clinical cohorts  Academic Article
• A practical approach to evidence-based dentistry  Academic Article
• A practical methodology for disaggregating the drivers of drug costs using administrative data  Academic Article
• A practitioner's guide to developing critical appraisal skills  Academic Article
• A prospective evaluation of edoxaban compared to warfarin in subjects undergoing cardioversion of atrial fibrillation: The EdoxabaN vs. warfarin in subjectS UndeRgoing cardiovErsion of Atrial Fibrillation (ENSURE-AF) study  Academic Article
• A prospective, double-blind, randomized, controlled clinical trial comparing standard wound care with adjunctive hyperbaric oxygen therapy (HBOT) to standard wound care only for the treatment of chronic, non-healing ulcers of the lower limb in patients with diabetes mellitus: a study protocol  Academic Article
• A protocol for a Canadian prospective observational study of decision-making on active surveillance or surgery for low-risk papillary thyroid cancer  Academic Article
• A protocol for a pragmatic randomized controlled trial using the Health Teams Advancing Patient Experience: Strengthening Quality (Health TAPESTRY) platform approach to promote person-focused primary healthcare for older adults  Academic Article
• A protocol for a systematic review on the impact of unpublished studies and studies published in the gray literature in meta-analyses  Academic Article
• A protocol for developing early warning score models from vital signs data in hospitals using ensembles of decision trees  Academic Article
• A quantitative analysis of qualitative studies in clinical journals for the 2000 publishing year  Academic Article
• A randomized trial of Pegaptanib sodium for age-related macular degeneration used an innovative design to explore disease-modifying effects  Academic Article
• A realist review to understand the efficacy and outcomes of interventions designed to minimise, reverse or prevent the progression of frailty  Academic Article
• A review of randomized controlled trials comparing the effectiveness of hand held computers with paper methods for data collection  Academic Article
• A risk of bias instrument for non-randomized studies of exposures: A users’ guide to its application in the context of GRADE  Academic Article
• A scoping review of comparisons between abstracts and full reports in primary biomedical research  Academic Article
• A small p-value from an observed data is not evidence of adequate power for future similar-sized studies: A cautionary note  Academic Article
• A systematic overview of adolescent suicide prevention programs.  Academic Article
• A systematic overview of the effectiveness of home visiting as a delivery strategy for public health nursing interventions.  Academic Article
• A systematic review of comparisons between protocols or registrations and full reports in primary biomedical research  Academic Article
• A systematic review of definitions and reporting of bleeding outcome measures in haemophilia  Academic Article
• A systematic review of lower extremity arterial revascularization economic analyses  Academic Article
• A systematic review of psychoeducational intervention trials for the management of chronic stable angina  Academic Article
• A systematic review of psychometric evaluations of outcome assessments for complex regional pain syndrome  Academic Article
• A systematic review of screening questionnaires for obstructive sleep apnea  Academic Article
• A systematic review of the quality of publications reporting coronary artery bypass grafting trials.  Academic Article
• A systematic review of the relationship between breastfeeding and early childhood caries.  Academic Article
• A systematic survey of the methods literature on the reporting quality and optimal methods of handling participants with missing outcome data for continuous outcomes in randomized controlled trials  Academic Article
• A systematic survey on reporting and methods for handling missing participant data for continuous outcomes in randomized controlled trials  Academic Article
• A tailored online safety and health intervention for women experiencing intimate partner violence: the iCAN Plan 4 Safety randomized controlled trial protocol  Academic Article
• A taxonomy and critical review of tested strategies for the application of clinical practice recommendations: from "official" to "individual" clinical policy.  Academic Article
• A three-stage approach to measuring health inequalities and inequities  Academic Article
• A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial  Academic Article
• A tutorial on pilot studies: the what, why and how  Academic Article
• A tutorial on sensitivity analyses in clinical trials: the what, why, when and how  Academic Article
• ACCOUNTING FOR BETWEEN-STUDY VARIATION IN INCREMENTAL NET BENEFIT IN VALUE OF INFORMATION METHODOLOGY  Academic Article
• AHRQ Series Paper 4: Assessing harms when comparing medical interventions: AHRQ and the Effective Health-Care Program  Academic Article
• APPLICATION OF THE CONSOLIDATED STANDARDS OF REPORTING TRIALS (CONSORT) IN THE FRACTURE CARE LITERATURE  Academic Article
• Above all, do no harm: Assessing the risk of an adverse reaction  Academic Article
• Academic Primer Series: Five Key Papers about Study Designs in Medical Education  Academic Article
• Academic response to improving value and reducing waste: A comprehensive framework for INcreasing QUality In patient-oriented academic clinical REsearch (INQUIRE)  Academic Article
• Accounting for center in the Early External Cephalic Version trials: an empirical comparison of statistical methods to adjust for center in a multicenter trial with binary outcomes  Academic Article
• Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial: Design and Methods  Academic Article
• Active patient involvement in the education of health professionals  Academic Article
• Acupuncture for the alleviation of lateral epicondyle pain: a systematic review  Academic Article
• Acute Cardiac Functional and Morphological Changes After Anthracycline Infusions in Children  Academic Article
• Addressing continuous data measured with different instruments for participants excluded from trial analysis: a guide for systematic reviewers  Academic Article
• Addressing efficiency: Economic evaluation and the agenda for CAM researchers  Academic Article
• Addressing the Unit of Analysis in Medical Care Studies  Academic Article
• Adherence measurement and patient recruitment methods are poor in intervention trials to improve patient adherence  Academic Article
• Adherence to Standards for Reporting Diagnostic Accuracy in Emergency Medicine Research  Academic Article
• Adolescents with cerebral palsy: stability in measurement of quality of life and health-related quality of life over 1 year  Academic Article
• Advanced statistics: understanding medical record review (MRR) studies.  Academic Article
• Advances in Genomic Analysis of Stroke  Academic Article
• Advancing Concussion Assessment in Pediatrics (A-CAP): a prospective, concurrent cohort, longitudinal study of mild traumatic brain injury in children: protocol study  Academic Article
• Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis  Academic Article
• Affective instability in personality disorders.  Academic Article
• Age-Specific Search Strategies for Medline  Academic Article
• Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time  Academic Article
• Agreement in reporting between trial publications and current clinical trial registry in high impact journals: A methodological review  Academic Article
• Algorithm for predicting death among older adults in the home care setting: study protocol for the Risk Evaluation for Support: Predictions for Elder-life in the Community Tool (RESPECT)  Academic Article
• All-arthroscopic versus mini-open repair of small or moderate-sized rotator cuff tears: A protocol for a randomized trial [NCT00128076]  Academic Article
• Alternatives to project-specific consent for access to personal information for health research: Insights from a public dialogue  Academic Article
• Although not consistently superior, the absolute approach to framing the minimally important difference has advantages over the relative approach  Academic Article
• An Assessment of Clinically Useful Measures of the Consequences of Treatment  Academic Article
• An Ep-ICD Based Index Is a Marker of Aggressiveness and Poor Prognosis in Thyroid Carcinoma  Academic Article
• An Introduction to Evidence-Based Practice for Hand Surgeons and Therapists  Academic Article
• An N of 1 Service: Applying the Scientific Method in Clinical Practice  Academic Article
• An Official ATS Statement: Grading the Quality of Evidence and Strength of Recommendations in ATS Guidelines and Recommendations  Academic Article
• An empirical comparison of methods for analyzing correlated data from a discrete choice survey to elicit patient preference for colorectal cancer screening  Academic Article
• An empirical study using permutation-based resampling in meta-regression  Academic Article
• An evaluation of the comparative effectiveness of geriatrician-led comprehensive geriatric assessment for improving patient and healthcare system outcomes for older adults: a protocol for a systematic review and network meta-analysis  Academic Article
• An evaluation of the structural validity of the shoulder pain and disability index (SPADI) using the Rasch model  Academic Article
• An evidence-based approach to gastroenterology therapy  Academic Article
• An exploratory cluster randomised controlled trial of knowledge translation strategies to support evidence-informed decision-making in local governments (The KT4LG study)  Academic Article
• An introduction to multiplicity issues in clinical trials: the what, why, when and how  Academic Article
• Analysis and Interpretation of Treatment Effects in Subgroups of Patients in Randomized Clinical Trials  Academic Article
• Analysis of Observational Studies: A Guide to Understanding Statistical Methods  Academic Article
• Ankylosing spondylitis antirheumatic drug trials. I. Effects of standardization procedures on observer dependent outcome measures.  Academic Article
• Ankylosing spondylitis antirheumatic drug trials. II. Tables for calculating sample size for clinical trials.  Academic Article
• Ankylosing spondylitis antirheumatic drug trials. III. Setting the delta for clinical trials of antirheumatic drugs--results of a consensus development (Delphi) exercise.  Academic Article
• Anticoagulant therapy for the thrombotic complications of the antiphospholipid antibody syndrome  Conference Paper
• Antioxidants in the prevention of human atherosclerosis. Summary of the proceedings of a National Heart, Lung, and Blood Institute Workshop: September 5-6, 1991, Bethesda, Maryland.  Academic Article
• Antithrombotic drug development for atrial fibrillation: Proceedings, Washington, DC, July 25-27, 2005  Academic Article
• Applicability of the AGREE II Instrument in Evaluating the Development Process and Quality of Current National Academy of Clinical Biochemistry Guidelines  Academic Article
• Application of the STROBE statement to the hypospadias literature: Report of the international pediatric urology task force on hypospadias  Academic Article
• Applying epidemiological principles to ergonomics: A checklist for incorporating sound design and interpretation of studies  Academic Article
• Appraisal of clinical practice guidelines for management of paediatric type 2 diabetes mellitus using the AGREE II instrument: a systematic review protocol  Academic Article
• Approaches to Psychiatric Research  Academic Article
• Archimedes: does caffeine treatment for apnoea of prematurity improve neurodevelopmental outcome in later life?  Academic Article
• Are current standards of reporting quality for clinical trials sufficient in addressing important sources of bias?  Academic Article
• Are placebo-controlled trials ethical in areas where current guidelines recommend therapy? No  Academic Article
• Are postbereavement research interviews distressing to carers? Lessons learned from palliative care research  Academic Article
• Are systematic reviews and meta-analyses still useful research? Yes  Academic Article
• Are the Results of the Extracranial–Intracranial Bypass Trial Generalizable?  Academic Article
• As a matter of fact: evidence-based decision-making unplugged.  Academic Article
• Aspirin and clonidine in non-cardiac surgery: acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation (POISE) 2 randomised controlled trial  Academic Article
• Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis  Academic Article
• Assessing proximal risks for acute traumatic events: the case-crossover design  Academic Article
• Assessing sensitivity to change: choosing the appropriate change coefficient.  Academic Article
• Assessing the effectiveness of ‘pulse radiofrequency treatment of dorsal root ganglion’ in patients with chronic lumbar radicular pain: study protocol for a randomized control trial  Academic Article
• Assessing the influence of researcher–partner involvement on the process and outcomes of participatory research in autism spectrum disorder and neurodevelopmental disorders: A scoping review  Academic Article
• Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta-analysis of randomized controlled trials  Academic Article
• Assessment of effectiveness of major bleeding management: proposed definitions for effective hemostasis: communication from the SSC of the ISTH  Academic Article
• Assessment of efficacy of varicocele repair for male subfertility: a systematic review  Academic Article
• Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol  Academic Article
• Association between BDNF levels and suicidal behaviour: a systematic review protocol  Academic Article
• Association between body mass index and suicidal behaviors: a systematic review protocol  Academic Article
• Association between cannabis use and treatment outcomes in patients receiving methadone maintenance treatment: a systematic review protocol  Academic Article
• Association between framing of the research question using the PICOT format and reporting quality of randomized controlled trials  Academic Article
• Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review  Academic Article
• Association between progression-free survival and health-related quality of life in oncology: a systematic review protocol  Academic Article
• Association between statistical significance and time to publication among systematic reviews: a study protocol for a meta-epidemiological investigation  Academic Article
• Assumptions of Expected Benefits in Randomized Phase III Trials Evaluating Systemic Treatments for Cancer  Academic Article
• Audience responses to a research-based drama about life after breast cancer  Academic Article
• Authors seldom report the most patient-important outcomes and absolute effect measures in systematic review abstracts  Academic Article
• Authorship and Ethical Considerations in the Conduct of Observational Studies  Academic Article
• Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial  Academic Article
• Balancing risk and benefit in venous thromboembolism trials: concept for a bivariate endpoint trial design and analytic approach  Academic Article
• Barrett's Oesophagus Surveillance versus endoscopy at need Study (BOSS): protocol and analysis plan for a multicentre randomized controlled trial  Academic Article
• Barriers to participating in an HIV vaccine trial  Academic Article
• Be careful about drawing conclusions.  Academic Article
• Before–after paired data  Academic Article
• Behavioral Interventions to Prevent Childhood Obesity: A Systematic Review and Metaanalyses of Randomized Trials  Academic Article
• Bench-to-bedside research and the human tumor stem-cell assay--bridging the credibility gap.  Academic Article
• Benchmarking: Applications to Transfusion Medicine  Academic Article
• Benefit-risk ratios in the assessment of the clinical evidence of a new therapy  Academic Article
• Best (but oft-forgotten) practices: intention-to-treat, treatment adherence, and missing participant outcome data in the nutrition literature  Academic Article
• Best (but oft-forgotten) practices: sensitivity analyses in randomized controlled trials  Academic Article
• Best (but oft-forgotten) practices: the multiple problems of multiplicity—whether and how to correct for many statistical tests  Academic Article
• Beyond the treatment effect: Evaluating the effects of patient preferences in randomised trials  Academic Article
• Bias in transfusion research: from study design to result reporting  Academic Article
• Bias-corrected estimator for intraclass correlation coefficient in the balanced one-way random effects model  Academic Article
• Biases in Evaluating Research: Are They All Bad?  Academic Article
• Binary Outcomes Are Not Better than Continuous Variables in Randomized Controlled Trials  Academic Article
• Body-mass index, abdominal adiposity, and cardiovascular risk  Academic Article
• Brazilian medicinal plants to treat upper respiratory tract and bronchial illness: systematic review and meta-analyses--study protocol  Academic Article
• Bridge or continue Coumadin for device surgery: a randomized controlled trial rationale and design  Academic Article
• Bringing health services research to (and from) critical care  Academic Article
• Bringing the Family's Voice to Research  Academic Article
• Building Undergraduate Nursing Students' Knowledge of the Research Process in Nursing  Academic Article
• Building clinical trial priorities at the University of Rwanda  Academic Article
• CIHR Candrive Cohort Comparison with Canadian Household Population Holding Valid Driver’s Licenses  Academic Article
• CNODES: the Canadian Network for Observational Drug Effect Studies.  Academic Article
• CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials  Academic Article
• CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomised trials  Academic Article
• CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials (Chinese version)  Academic Article
• CONSORT and clinical trial reporting: room for improvement  Academic Article
• CONSORT comes to TRANSFUSION  Academic Article
• CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement  Academic Article
• CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement  Academic Article
• CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration  Academic Article
• COST AND EFFICIENCY IN THE CHOICE OF MATCHED AND UNMATCHED CASE-CONTROL STUDY DESIGNS1  Academic Article
• CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients  Academic Article
• Calidad y fuerza: el sistema GRADE para la formulación de recomendaciones en las guías de práctica clínica  Academic Article
• Can We Learn Anything from Small Trials?  Academic Article
• Can an antimicrobial stewardship program reduce length of stay of immune-competent adult patients admitted to hospital with diagnosis of community-acquired pneumonia? Study protocol for pragmatic controlled non-randomized clinical study  Academic Article
• Can observational studies replace or complement experiment?  Academic Article
• Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?  Academic Article
• Can we differentiate the low-molecular-weight heparins?  Academic Article
• Can you use a sequential sample of patients as a substitute for a full practice audit?: Study of mammography screening rates in 20 family practices in Ontario.  Academic Article
• Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT): Rationale and protocol  Academic Article
• Canadian Phase III Randomized Trial of Stereotactic Body Radiotherapy Versus Conventionally Hypofractionated Radiotherapy for Stage I, Medically Inoperable Non–Small-Cell Lung Cancer – Rationale and Protocol Design for the Ontario Clinical Oncology Group (OCOG)-LUSTRE Trial  Academic Article
• Canadian study of health and aging: study methods and prevalence of dementia.  Academic Article
• Candesartan in heart failure—assessment of reduction in mortality and morbidity (CHARM): Rationale and design  Academic Article
• Capture-mark-recapture to estimate the number of missed articles for systematic reviews in surgery  Academic Article
• Cardiac rehabilitation after myocardial infarction. Combined experience of randomized clinical trials  Academic Article
• Cardiovascular Thrombotic Events in Controlled, Clinical Trials of Rofecoxib  Academic Article
• Case-control studies for the evaluation of screening  Academic Article
• Celebrities’ impact on health-related knowledge, attitudes, behaviors, and status outcomes: protocol for a systematic review, meta-analysis, and meta-regression analysis  Academic Article
• Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience  Academic Article
• Central statistical monitoring: Detecting fraud in clinical trials  Academic Article
• Central venous catheter replacement strategies  Academic Article
• Challenges in Systematic Reviews That Evaluate Drug Efficacy or Effectiveness  Academic Article
• Challenges in designing antirheumatic drug trials.  Academic Article
• Challenges in reproducibility of genetic association studies: lessons learned from the obesity field  Academic Article
• Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction  Academic Article
• Challenges to complete and useful data sharing  Academic Article
• Challenges to the Design, Execution, and Analysis of Randomized Controlled Trials for Inflammatory Bowel Disease  Academic Article
• Chapter 5: Assessing Risk of Bias as a Domain of Quality in Medical Test Studies  Academic Article
• Chemotherapy for recurrent, metastatic, or persistent cervical cancer: a systematic review  Academic Article
• Child hunger in Canada.  Academic Article
• Chronic pain self-management support with pain science education and exercise (COMMENCE): study protocol for a randomized controlled trial  Academic Article
• Clinical Commentary in Response To: Relationship between Patient Satisfaction and Functional Outcome Metrics 3 Months after Surgical Treatment for Distal Radius Fractures  Academic Article
• Clinical Experience and Quality of Health Care  Academic Article
• Clinical Presentation of Attention-Deficit/Hyperactivity Disorder in Preschool Children: The Preschoolers with Attention-Deficit/Hyperactivity Treatment Study (PATS)  Academic Article
• Clinical Research Designs: Quantitative Studies  Academic Article
• Clinical Research in Aesthetic Surgery  Academic Article
• Clinical Research in Breast Surgery: Reduction and Postmastectomy Reconstruction  Academic Article
• Clinical Research in Head and Neck Reconstruction  Academic Article
• Clinical Research in Pediatric Plastic Surgery and Systematic Review of Quality-of-Life Questionnaires  Academic Article
• Clinical Trial Design in Acute Lung Injury—Issues and Controversies  Academic Article
• Clinical Trial Design in Fracture-Healing Research: Meeting the Challenge  Academic Article
• Clinical Usefulness of n-of-1 Randomized Controlled Trials in Patients with Nonreversible Chronic Airflow Limitation  Academic Article
• Clinical and Methodological Factors Related to Reliability of the Best-Estimate Diagnostic Procedure  Academic Article
• Clinical case reports and case series research in evaluating surgery. Part II. The content and form: uses of single clinical case reports and case series research in surgical specialties.  Academic Article
• Clinical comparisons of inhaler systems: what are the important aspects?  Academic Article
• Clinical diagnostic criteria for premenstrual syndrome and guidelines for their quantification for research studies  Academic Article
• Clinical experience may affect clinician compliance with assigned treatment in randomized trials  Academic Article
• Clinical impact versus factor analysis for quality of life questionnaire construction  Academic Article
• Clinical interventions, implementation interventions, and the potential greyness in between -a discussion paper  Academic Article
• Clinical markers of endometriosis: Have we been too quick to judge?  Academic Article
• Clinical practice guideline on the use of manipulation or mobilization in the treatment of adults with mechanical neck disorders  Academic Article
• Clinical research design and reporting: always room for improvement!  Academic Article
• Clinical trial opportunities in hemostasis and thrombosis: NHBLI State-of-the-science symposium  Academic Article
• Clinical trials evaluating pathogen-reduced platelet products: methodologic issues and recommendations  Academic Article
• Clinician trialist rounds: 28. When RCT participants are lost to follow-up. Part 1: Why even a few can matter  Academic Article
• Clinician-trialist rounds: 11. When your grant gets turned down – part 1: remorse, anger, and reconciliation  Academic Article
• Clinician-trialist rounds: 25. Designing an evidence-based introductory graduate course in clinical trials. Part 2: Applying the evidence to your RCT course design  Academic Article
• Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol)  Academic Article
• Cochrane reviews in perspective: the importance of appropriate conclusions and timing of publication  Academic Article
• Coenrollment in a Randomized Trial of High-Frequency Oscillation  Conference Paper
• Cohort Profile: The Canadian Observational Cohort collaboration  Academic Article
• Collaborative leadership and the implementation of community-based fall prevention initiatives: a multiple case study of public health practice within community groups  Academic Article
• Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation  Academic Article
• Colloid Use for Fluid Resuscitation: Evidence and Spin  Academic Article
• Comment on “Perspective: NutriGrade: A Scoring System to Assess and Judge the Meta-Evidence of Randomized Controlled Trials and Cohort Studies in Nutrition Research”  Academic Article
• Commentary III - Making workplaces healthier: generating better evidence on work organization intervention research  Academic Article
• Commentary: Are the Correct Outcomes of Prenatal Education Being Measured?  Academic Article
• Comments on ‘Sequential meta-analysis: an efficient decision-making tool’ by I van der Tweel and C Bollen  Academic Article
• Common Pitfalls in the Conduct of Clinical Research  Academic Article
• Common data elements for clinical research in mitochondrial disease: a National Institute for Neurological Disorders and Stroke project  Academic Article
• Communication Beliefs About Youth and Old Age in Asia and Canada  Academic Article
• Community service provider perceptions of implementing older adult fall prevention in Ontario, Canada: a qualitative study  Academic Article
• Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses  Academic Article
• Comparing the effectiveness of copper intrauterine devices available in Canada. Is FlexiT non-inferior to NovaT when inserted immediately after first-trimester abortion? Study protocol for a randomized controlled trial  Academic Article
• Comparing the feasibility, acceptability, clinical-, and cost-effectiveness of mental health e-screening to paper-based screening on the detection of depression, anxiety, and psychosocial risk in pregnant women: a study protocol of a randomized, parallel-group, superiority trial  Academic Article
• Comparison between the standard and a new alternative format of the Summary-of-Findings tables in Cochrane review users: study protocol for a randomized controlled trial  Academic Article
• Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation  Academic Article
• Comparison of Echocardiographic and Cardiac Magnetic Resonance Imaging for Assessing Right Ventricular Function in Adults With Repaired Tetralogy of Fallot  Academic Article
• Comparison of Standardization Methods for the Harmonization of Phenotype Data: An Application to Cognitive Measures  Academic Article
• Comparison of health-related quality of life in patients with atrial fibrillation treated with catheter ablation or antiarrhythmic drug therapy: a systematic review and meta-analysis protocol  Academic Article
• Comparison of physical interventions, behavioral interventions, natural health products, and pharmacologics to manage hot flashes in patients with breast or prostate cancer: protocol for a systematic review incorporating network meta-analyses  Academic Article
• Comparison of questionnaires determining patient satisfaction with medical care.  Academic Article
• Comparison of the ability of double-robust estimators to correct bias in propensity score matching analysis. A Monte Carlo simulation study  Academic Article
• Complementary medicine and older people: past research and future directions  Academic Article
• Complication Reporting in Orthopaedic Trials  Academic Article
• Comprehensiveness and bias in reporting clinical trials. Study of reviews of pneumococcal vaccine effectiveness.  Academic Article
• Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies  Academic Article
• Concerns about the critical appraisal of the role of H pylori in dyspepsia.  Academic Article
• Concurrent Cisplatin-based Chemotherapy plus Radiotherapy for Cervical Cancer:  Academic Article
• Conditional analysis of mixed Poisson processes with baseline counts: implications for trial design and analysis  Academic Article
• Conducting EQ-5D Valuation Studies in Resource-Constrained Countries: The Potential Use of Shrinkage Estimators to Reduce Sample Size  Academic Article
• Conducting economic evaluations alongside multinational clinical trials: Toward a research consensus  Academic Article
• Conducting industry-partnered trials in orthopaedic surgery  Academic Article
• Confidentiality and prescriptions.  Academic Article
• Confounding: What is it and how do we deal with it?  Academic Article
• Confronting the Confounders: The Meaning, Detection, and Treatment of Confounders in Research  Academic Article
• Consensus statement on the methodology of injury and illness surveillance in FINA (aquatic sports): Table 1  Academic Article
• Consent for use of personal information for health research: Do people with potentially stigmatizing health conditions and the general public differ in their opinions?  Academic Article
• Consent, including advanced consent, of older adults to research in care homes: a qualitative study of stakeholders’ views in South Wales  Academic Article
• Considerations and guidance in designing equity-relevant clinical trials  Academic Article
• Consistency of Phase III Clinical Trial Abstracts Presented at an Annual Meeting of the American Society of Clinical Oncology Compared With Their Subsequent Full-Text Publications  Conference Paper
• Consolidation Therapy With Autologous Bone Marrow Transplantation in Adults With Acute Myeloid Leukemia: A Meta-analysis  Academic Article
• Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials  Academic Article
• Constructing trials to show whether urodynamic studies are necessary in lower urinary tract dysfunction  Academic Article
• Construction of social value or utility-based health indices: The usefulness of factorial experimental design plans  Academic Article
• Content and methods of studies on the prevention and treatment of mental disorders in selected psychiatric journals.  Academic Article
• Controversy in Counting and Attributing Events in Clinical Trials  Academic Article
• Coronary stent assessability by 64 slice multi-detector computed tomography  Academic Article
• Correction for Multiple Testing  Academic Article
• Correction to the Relative Risk Calculation for Gadolinium-enhanced MR Imaging and Nephrogenic Systemic Fibrosis  Academic Article
• Correction: Reported Methodologic Quality and Discrepancies between Large and Small Randomized Trials in Meta-Analyses  Academic Article
• Correlation of single arm versus randomised phase 2 oncology trial characteristics with phase 3 outcome  Academic Article
• Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial  Academic Article
• Corticosteroid treatment for sepsis  Academic Article
• Corticosteroids in sepsis: an updated systematic review and meta-analysis (protocol)  Academic Article
• Cost Implication of an Early Invasive Strategy on Weekdays and Weekends in Patients With Acute Coronary Syndromes  Academic Article
• Counting Events in Clinical Trials  Academic Article
• Counting the cost of proton pump inhibitors  Academic Article
• Credibility of claims of subgroup effects in randomised controlled trials: systematic review  Academic Article
• Critical Appraisal of Research Evidence for Its Validity and Usefulness  Academic Article
• Critical Care Cardiology Research  Academic Article
• Critical appraisal of rigour in interpretive phenomenological nursing research  Academic Article
• Critical appraisal of the health research literature: prevalence or incidence of a health problem.  Academic Article
• Cross-linkedversusconventional polyethylene for total hip replacement  Academic Article
• Crossover trials with a cumulative response  Academic Article
• Current Pain-Control Practices and Research☆☆☆★  Conference Paper
• Curved versusStraight Stem UncementedTotal Hip ArthroplastyOsteoarthritisMulticenter trial (CUSTOM): design of a prospective blinded randomised controlled multicentre trial: Table 1  Academic Article
• Cyclophosphamide and plasma exchange in multiple sclerosis  Academic Article
• Dabigatran monitoring made simple?  Academic Article
• Data based medicine and clinical judgement.  Academic Article
• Data withdrawal in randomized controlled trials: Defining the problem and proposing solutions  Academic Article
• Dating violence in mid-adolescence Theory, significance, and emerging prevention initiatives  Academic Article
• Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer: update to study protocol with follow-up extension  Academic Article
• Decolonizing Scoping Review Methodologies for Literature With, for, and by Indigenous Peoples and the African Diaspora: Dialoguing With the Tensions  Academic Article
• Defining clinically important perioperative blood loss and transfusion for the Standardised Endpoints for Perioperative Medicine (StEP) collaborative: a protocol for a scoping review  Academic Article
• Defining publication bias: protocol for a systematic review of highly cited articles and proposal for a new framework  Academic Article
• Defining the Outcome Measures for Out-of-hospital Trials in Acute Pulmonary Edema  Conference Paper
• Definitions of extubation success in very premature infants: a systematic review  Academic Article
• Demystifying trial networks and network meta-analysis  Academic Article
• Deprescribing anticholinergic and sedative medicines: protocol for a Feasibility Trial (DEFEAT-polypharmacy) in residential aged care facilities  Academic Article
• Design and Analytic Considerations in Determining the Cost-Effectiveness of Early Intervention in Asthma from a Multinational Clinical Trial  Academic Article
• Design and Rationale of Health-Related Quality of Life and Patient-Reported Outcomes Assessment in the Frequent Hemodialysis Network Trials  Conference Paper
• Design and Use of a Quantitative Scale for Measuring Presyncope  Academic Article
• Design and assessment of clinical trials on continuous infusion.  Conference Paper
• Design and baseline characteristics of participants in the R esearching cardiovascular E vents with a W eekly IN cretin in D iabetes ( REWIND ) trial on the cardiovascular effects of dulaglutide  Academic Article
• Design and methods of the MAINTAIN study: A randomized controlled clinical trial of micronutrient and antioxidant supplementation in untreated HIV infection  Academic Article
• Design and rationale for RE-VERSE AD: A phase 3 study of idarucizumab, a specific reversal agent for dabigatran  Academic Article
• Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial  Academic Article
• Design and rationale of the Treatment of Acute Coronary Syndromes with Otamixaban trial: A double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non–ST-segment elevation acute coronary syndromes with a planned early invasive strategy  Academic Article
• Design considerations for randomised trials in orthopaedic fracture surgery  Academic Article
• Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis  Academic Article
• Design of the fish oil inhibition of stenosis in hemodialysis grafts (FISH) study  Academic Article
• Design of the rivaroxaban for heparin-induced thrombocytopenia study  Academic Article
• Design, Conduct, and Interpretation of Nonrandomized Orthopaedic Studies: A Practical Approach  Academic Article
• Design, Progress and Challenges of a Double-Blind Trial of Warfarin versus Aspirin for Symptomatic Intracranial Arterial Stenosis  Academic Article
• Design, analysis, and presentation of crossover trials  Academic Article
• Designing Medical Informatics Research and Library--Resource Projects to Increase What Is Learned  Academic Article
• Designing and Analyzing Clinical Trials with Composite Outcomes: Consideration of Possible Treatment Differences between the Individual Outcomes  Academic Article
• Designing and Reporting Case Series in Plastic Surgery  Academic Article
• Designing laboratory-based research studies: is it time for a change?  Academic Article
• Designing research in vulnerable populations: lessons from HIV prevention trials that stopped early  Academic Article
• Detecting, quantifying and adjusting for publication bias in meta-analyses: protocol of a systematic review on methods  Academic Article
• Determinants of Walking Exercise Among Individuals With Intermittent Claudication  Academic Article
• Determining Optimal Therapy — Randomized Trials in Individual Patients  Academic Article
• Determining causation—A case study: Adrenocorticosteroids and osteoporosis  Academic Article
• Determining optimal sample sizes for multi-stage randomized clinical trials using value of information methods  Academic Article
• Determining optimal sample sizes for multistage adaptive randomized clinical trials from an industry perspective using value of information methods  Academic Article
• Determining the Level of Statistician Participation on Canadian-Based Research Ethics Boards  Academic Article
• Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial  Academic Article
• Determining the reporting quality of RCTs in clinical pharmacology.  Academic Article
• Developing Optimal Search Strategies for Detecting Clinically Sound Studies in MEDLINE  Academic Article
• Developing and Implementing a Triangulation Protocol for Qualitative Health Research  Academic Article
• Developing optimal search strategies for detecting clinically sound and relevant causation studies in EMBASE  Academic Article
• Development and Validation of a Set of Palliative Medicine Entrustable Professional Activities: Findings from a Mixed Methods Study  Academic Article
• Development and feasibility testing of decision support for patients who are candidates for a prophylactic implantable defibrillator: a study protocol for a pilot randomized controlled trial  Academic Article
• Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations  Academic Article
• Development of a Policy-Relevant Child Maltreatment Research Strategy  Academic Article
• Development of a Research Agenda for Inferior Vena Cava Filters: Proceedings from a Multidisciplinary Research Consensus Panel  Academic Article
• Development of a measure of family-centred care for resource-poor South African settings: the experience of using a modified version of the MPOC-20  Academic Article
• Development of an instrument to assess individual student performance in small group tutorials.  Academic Article
• Development of the Assistance to Participate Scale (APS) for children's play and leisure activities  Academic Article
• Diagnostic Efficacy of Impedance Plethysmography for Clinically Suspected Deep-Vein Thrombosis  Academic Article
• Dietary Calcium and Blood Pressure  Academic Article
• Differences between the real and the desired worlds in the results of clinical trials  Academic Article
• Differential Student Attrition and Differential Exposure Mask Effects of Problem-Based Learning in Curriculum Comparison Studies  Academic Article
• Digitalis for treatment of congestive heart failure in patients in sinus rhythm: a systematic review and meta-analysis  Academic Article
• Discharge Criteria From Perioperative Physical Therapy  Academic Article
• Discrepancies among megatrials  Academic Article
• Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results: achieving clarity through mixed methods triangulation  Academic Article
• Diurnal variation of testosterone and estradiol: a source of bias in comparative studies on breast cancer  Academic Article
• Diversity and homelessness: minorities and psychiatric survivors.  Academic Article
• Do Authors Report Surgical Expertise in Open Spine Surgery Related Randomized Controlled Trials? A Systematic Review on Quality of Reporting  Academic Article
• Do You See What I Mean? Indices of Central Tendency  Academic Article
• Do hip protectors decrease the risk of hip fracture in institutional and community-dwelling elderly? A systematic review and meta-analysis of randomized controlled trials  Academic Article
• Do physicians need objective measurements to diagnose asthma?  Academic Article
• Do systematic reviews on pediatric topics need special methodological considerations?  Academic Article
• Do we measure the right end points? A systematic review of primary outcomes in recent neonatal randomized clinical trials  Academic Article
• Doctors' perceptions of the effects of interventions tested in prospective, randomised, controlled, clinical trials: results of a survey of ICU physicians  Academic Article
• Does Study Design Affect Redislocation Rates After Primary Shoulder Dislocations? A Systematic Review Comparing Prospective and Retrospective Studies  Academic Article
• Does a "Level I Evidence" rating imply high quality of reporting in orthopaedic randomised controlled trials?  Academic Article
• Does benefit justify research with children?  Academic Article
• Does clinical equipoise apply to cluster randomized trials in health research?  Academic Article
• Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?  Academic Article
• Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes  Academic Article
• Double blind, you are the weakest link - goodbye!  Academic Article
• Drugs and the DST: need for a reappraisal  Academic Article
• Drugs commonly associated with weight change: umbrella systematic review and meta-analysis (Protocol)  Academic Article
• EPISIOTOMY: EFFECTS OF A RESEARCH PROTOCOL ON CLINICAL PRACTICE  Academic Article
• Early studies reported extreme findings with large variability: a meta-epidemiologic study in the field of endocrinology  Academic Article
• Economic Evaluations Conducted for Assessment of Genetic Testing Technologies: A Systematic Review  Academic Article
• Economic analysis and clinical trials  Academic Article
• Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial  Academic Article
• Economic evaluations conducted by Canadian health technology assessment agencies: Where do we stand?  Academic Article
• Economic evaluations in the critical care literature  Academic Article
• Editorial  Academic Article
• Editorial ? Beyond PBL  Academic Article
• Editorial Comment  Academic Article
• Editorial: Two cheers for clinical practice guidelines: the hopes and headaches of quality improvement in reproductive healthcare  Academic Article
• Edoxaban for treatment of venous thromboembolism in patients with cancer  Academic Article
• Effect of Atenolol on Mortality and Cardiovascular Morbidity after Noncardiac Surgery  Academic Article
• Effect of Fructose on Body Weight in Controlled Feeding Trials  Academic Article
• Effect of Metformin vs Placebo on and Metabolic Factors in NCIC CTG MA.32  Academic Article
• Effect of Smoking Cessation on Mortality After Myocardial Infarction  Academic Article
• Effect of an interactive text-messaging service on patient retention during the first year of HIV care in Kenya (WelTel Retain): an open-label, randomised parallel-group study  Academic Article
• Effect of influenza vaccines against mismatched strains: a systematic review protocol  Academic Article
• Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomised trials  Academic Article
• Effect of religious involvement on cognition from a life-course perspective: protocol for a systematic review and meta-analysis  Academic Article
• Effect of serotonin modulating pharmacotherapies on body mass index and dysglycaemia among children and adolescents: a systematic review and network meta-analysis protocol  Academic Article
• Effective Ventilation Strategies for Acute Respiratory Distress Syndrome  Academic Article
• Effectiveness of Percutaneous Coronary Intervention in Patients With Silent Myocardial Ischemia (Post Hoc Analysis of the COURAGE Trial)  Academic Article
• Effectiveness of guideline dissemination and implementation strategies on health care professionals’ behaviour and patient outcomes in the cancer care context: a systematic review protocol  Academic Article
• Effectiveness of implementation strategies in improving physician adherence to guideline recommendations in heart failure: a systematic review protocol  Academic Article
• Effectiveness of instruction in critical appraisal (evidence-based medicine) skills: a critical appraisal.  Academic Article
• Effectiveness of knowledge translation tools addressing multiple high-burden chronic diseases affecting older adults: protocol for a systematic review alongside a realist review  Academic Article
• Effectiveness of seasonal influenza vaccination in community-dwelling elderly people: an individual participant data meta-analysis of test-negative design case-control studies  Academic Article
• Effectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial  Academic Article
• Effectiveness of the head CT choice decision aid in parents of children with minor head trauma: study protocol for a multicenter randomized trial  Academic Article
• Effects of Atrazine in Fish, Amphibians, and Reptiles: An Analysis Based on Quantitative Weight of Evidence  Academic Article
• Effects of Intravenously Administered Recombinant Vesicular Stomatitis Virus (VSV ΔM51 ) on Multifocal and Invasive Gliomas  Academic Article
• Effects of an evidence service on health-system policy makers' use of research evidence: A protocol for a randomised controlled trial  Academic Article
• Effects of electroconvulsive therapy on cognitive functioning in patients with depression: protocol for a systematic review and meta-analysis  Academic Article
• Effects of study design and trends for EVAR versus OSR  Academic Article
• Efficacy and Safety of Melatonin as an Anxiolytic and Analgesic in the Perioperative Period  Academic Article
• Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials  Academic Article
• Efficacy of azathioprine versus mesalazine in postoperative Crohn's disease-The Authors' response  Academic Article
• Efficacy of temporary work modifications on disability related to musculoskeletal pain or depressive symptoms--study protocol for a controlled trial  Academic Article
• Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol  Academic Article
• Embryonic stem cells: advances toward potential therapeutic use  Academic Article
• Emerging Designs in Orthopaedics: Expertise-Based Randomized Controlled Trials  Academic Article
• Emerging Trends in Clinical Trial Design  Academic Article
• Empirical Testing of the External Validity of a Discrete Choice Experiment to Determine Preferred Treatment Option: The Case of Sleep Apnea  Academic Article
• Empirical comparison of methods for analyzing multiple time-to-event outcomes in a non-inferiority trial: a breast cancer study  Academic Article
• Empirical evidence of bias in infertility research: overestimation of treatment effect in crossover trials using pregnancy as the outcome measure  Academic Article
• Empirically evaluating the impact of adjudicative tribunals in the health sector: context, challenges and opportunities  Academic Article
• End-of-Life Care for Seniors: contributions from a New Emerging Team.  Academic Article
• Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis  Academic Article
• Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective  Academic Article
• Endovascular repair of ruptured abdominal aortic aneurysms: A systematic review and meta-analysis  Academic Article
• Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel  Academic Article
• Engaging First Nation and Inuit communities in asthma management and control: assessing cultural appropriateness of educational resources.  Academic Article
• Enhancing primary reports of randomized controlled trials: Three most common challenges and suggested solutions  Academic Article
• Environmental Profile of a Community’s Health (EPOCH): An Ecometric Assessment of Measures of the Community Environment Based on Individual Perception  Academic Article
• Epistemologic Inquiries in Evidence-Based Medicine  Academic Article
• Equity considerations in utility-based measures of health outcomes in economic appraisals: An adjustment algorithm  Academic Article
• Error-related electrocortical responses in 10-year-old children and young adults  Academic Article
• Errors in kinematic parameters of a planar joint: Guidelines for optimal experimental design  Academic Article
• Establishing a protocol for building a pan-Canadian population-based monitoring system for early childhood development for children with health disorders: Canadian Children’s Health in Context Study (CCHICS)  Academic Article
• Estimates of general practitioner workload: a review.  Academic Article
• Estimating the Power of Indirect Comparisons: A Simulation Study  Academic Article
• Ethical and policy issues in cluster randomized trials: rationale and design of a mixed methods research study  Academic Article
• Ethical review of interpretive research: problems and solutions.  Academic Article
• European multicentre double-blind placebo-controlled trial of Nilvadipine in mild-to-moderate Alzheimer's disease—the substudy protocols: NILVAD frailty; NILVAD blood and genetic biomarkers; NILVAD cerebrospinal fluid biomarkers; NILVAD cerebral blood flow  Academic Article
• Evaluating Agreement: Conducting a Reliability Study  Academic Article
• Evaluating Implants in Orthopaedic Trials: Tips for Conducting Research  Academic Article
• Evaluating a community-based exercise intervention with adults living with HIV: protocol for an interrupted time series study  Academic Article
• Evaluating health related quality of life: An indifference curve interpretation for the time trade-off technique  Academic Article
• Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial  Academic Article
• Evaluating the design and reporting of pragmatic trials in osteoarthritis research  Academic Article
• Evaluating the effectiveness, impact and safety of live attenuated and seasonal inactivated influenza vaccination: protocol for the Seasonal Influenza Vaccination Effectiveness II (SIVE II) study  Academic Article
• Evaluation of WOMAC 20, 50, 70 response criteria in patients treated with hylan G-F 20 for knee osteoarthritis  Academic Article
• Evaluation of a physiatrist-directed prehabilitation intervention in frail patients with colorectal cancer: a randomised pilot study protocol  Academic Article
• Evaluation of a research mentorship program in community care  Academic Article
• Evaluation of innovations in nursing practice: report and discussion  Academic Article
• Evaluation of multisystemic therapy pilot services in Services for Teens Engaging in Problem Sexual Behaviour (STEPS-B): study protocol for a randomized controlled trial  Academic Article
• Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methods  Academic Article
• Evaluation of the Effectiveness of Suicide Prevention Programs: A Methodological Perspective  Academic Article
• Evaluation research in public health: barriers to the production and dissemination of outcomes data.  Academic Article
• Event-related potential sensitivity to acoustic and semantic properties of terminal words in sentences  Academic Article
• Evidence and its uses in health care and research: The role of critical thinking  Academic Article
• Evidence base of clinical diagnosis: The architecture of diagnostic research  Academic Article
• Evidence-Based Guidelines--An Introduction  Academic Article
• Evidence-Based Medicine  Academic Article
• Evidence-Based Medicine: Application in Alzheimer's Disease Research  Academic Article
• Evidence-Based Priority Setting for Health Care and Research: Tools to Support Policy in Maternal, Neonatal, and Child Health in Africa  Academic Article
• Evidence-based decision-making in infectious diseases epidemiology, prevention and control: matching research questions to study designs and quality appraisal tools  Academic Article
• Evidence-based medicine.  Academic Article
• Evidence-based neonatology: making a difference beyond discharge from the neonatal nursery  Academic Article
• Evidence-based practice guidelines for instructing individuals with neurogenic memory impairments: What have we learned in the past 20 years?  Academic Article
• Evidence-based practice: what it is, why we need it.  Academic Article
• Examining health promotion interventions for patients with chronic conditions using a novel patient-centered complexity model: protocol for a systematic review and meta-analysis  Academic Article
• Examining the social determinants of children's developmental health: protocol for building a pan-Canadian population-based monitoring system for early childhood development  Academic Article
• Executive functioning: A scoping review of the occupational therapy literature / Les fonctions exécutives : une analyse de la portée de la littérature en ergothérapie  Academic Article
• Exercise research issues in the spinal cord injured population.  Academic Article
• Expected value of information and decision making in HTA  Academic Article
• Exploring design-related bias in clinical studies on receptor genetic polymorphism of hypertension  Academic Article
• Exploring some intersections between pharmacokinetics, factor VIII measurement and human morphometrics - impact of recent advances in haemophilia study design on our understanding of optimal haemophilia treatment  Academic Article
• Exploring the experiences of substitute decision-makers with an exception to consent in a paediatric resuscitation randomised controlled trial: study protocol for a qualitative research study  Academic Article
• Exploring the uptake and framing of research evidence on universal screening for intimate partner violence against women: a knowledge translation case study  Academic Article
• FENOTEROL AND FATAL ASTHMA  Academic Article
• Facilitating the Use of Evidence in Practice: Evaluating and Adapting Clinical Practice Guidelines for Local Use by Health Care Organizations  Academic Article
• Factorial experimental designs  Academic Article
• Factors affecting exhaled nitric oxide measurements: the effect of sex  Academic Article
• Factors associated with citation rates in the orthopedic literature.  Academic Article
• Factors associated with development of gastrointestinal problems in patients with scleroderma: a protocol for a systematic review  Academic Article
• Factors associated with development of gastrointestinal problems in patients with scleroderma: a systematic review  Academic Article
• Feasibility of a Systematic, Comprehensive, One-to-One Training (SCOOT) program for new scooter users: study protocol for a randomized control trial  Academic Article
• Feasibility of a randomized controlled trial to evaluate the impact of decision boxes on shared decision-making processes  Academic Article
• Feasibility of the Enhancing Participation In the Community by improving Wheelchair Skills (EPIC Wheels) program: study protocol for a randomized controlled trial  Academic Article
• Financial and family burden associated with cancer treatment in Ontario, Canada  Academic Article
• Finding Common Ground in Team-Based Qualitative Research Using the Convergent Interviewing Method  Academic Article
• First international symposium on places of death: an agenda for the 21st century.  Academic Article
• Five conversations: reflections of stakeholders on the impact of the ethnocultural communities facing AIDS study.  Academic Article
• Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures  Academic Article
• Fluid Lavage of Open Wounds (FLOW): design and rationale for a large, multicenter collaborative 2 × 3 factorial trial of irrigating pressures and solutions in patients with open fractures  Academic Article
• Fluid lavage in patients with open fracture wounds (FLOW): an international survey of 984 surgeons  Academic Article
• Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial  Academic Article
• Fondaparinux and prevention of venous thromboembolism after orthopaedic surgery  Academic Article
• Fondaparinux in the management of patients with ST-elevation acute myocardial infarction  Academic Article
• Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT) – Bridging the River Coumarin  Academic Article
• Forecasting models for human resources in health care  Academic Article
• Formatting modifications in GRADE evidence profiles improved guideline panelists comprehension and accessibility to information. A randomized trial  Academic Article
• Forming the Research Question  Academic Article
• Fracture Risk Assessment in Chronic Kidney Disease, Prospective Testing Under Real World Environments (FRACTURE): a prospective study  Academic Article
• Fracture Risk in Kidney Transplant Recipients  Academic Article
• Framing of research question using the PICOT format in randomised controlled trials of venous ulcer disease: a protocol for a systematic survey of the literature  Academic Article
• Frequent Hemodialysis Network (FHN) randomized trials: Study design  Academic Article
• From diversity comes understanding: health promotion capacity-building and dissemination research in Canada.  Academic Article
• From sea to shining sea: making collaborative rural research work.  Academic Article
• Functional Dyspepsia Treatment Trial (FDTT): A double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics  Academic Article
• Functioning and disability in recent research from Cameroon: a narrative synthesis  Academic Article
• Funding Oncology Clinical Trials: Are Cooperative Group Trials Sustainable?  Academic Article
• Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial  Academic Article
• Further studies are needed to assess the competing therapies for neck pain  Academic Article
• GENERATING HEALTH TECHNOLOGY ASSESSMENT EVIDENCE FOR RARE DISEASES  Academic Article
• GRADE Equity Guidelines 2: Considering health equity in GRADE guideline development: Equity extension of the Guideline Development Checklist  Academic Article
• GRADE Leitlinien: 13. Erstellen von Summary-of-Findings-Tabellen und Evidenzprofilen – kontinuierliche Endpunkte  Academic Article
• GRADE equity guidelines 1: considering health equity in GRADE guideline development: introduction and rationale  Academic Article
• GRADE equity guidelines 3: considering health equity in GRADE guideline development: rating the certainty of synthesized evidence  Academic Article
• GRADE equity guidelines 4: considering health equity in GRADE guideline development: evidence to decision process  Academic Article
• GRADE guidelines 17: assessing the risk of bias associated with missing participant outcome data in a body of evidence  Academic Article
• GRADE guidelines: 12. Preparing Summary of Findings tables—binary outcomes  Academic Article
• GRADE guidelines: 15. Going from evidence to recommendation—determinants of a recommendation's direction and strength  Academic Article
• GRADE guidelines: 7. Rating the quality of evidence—inconsistency  Academic Article
• GRADE-Leitlinien: 11. Gesamtbeurteilung des Vertrauens in Effektschätzer für einen einzelnen Studienendpunkt und für alle Endpunkte  Academic Article
• GRADE-Leitlinien: 12. Erstellen von „Summary-of-Findings“-Tabellen – Dichotome Endpunkte  Academic Article
• Gabapentinoids for chronic low back pain: a protocol for systematic review and meta-analysis of randomised controlled trials  Academic Article
• General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial  Academic Article
• Generalizability theory for the perplexed: A practical introduction and guide: AMEE Guide No. 68  Academic Article
• Generalization and the qualitative–quantitative debate  Academic Article
• Generating evidence on a risk-based monitoring approach in the academic setting – lessons learned  Academic Article
• Genetic Polymorphisms and Head and Neck Cancer Outcomes: A Review  Academic Article
• Genome-Scale Phylogeny and the Detection of Systematic Biases  Academic Article
• Geographies of Risk in Studies Linking Chronic Air Pollution Exposure to Health Outcomes  Academic Article
• Global Anticoagulant Registry in the Field – Venous Thromboembolism (GARFIELD-VTE)  Academic Article
• Glycemic Control in Non-Critically Ill Hospitalized Patients: A Systematic Review and Meta-Analysis  Academic Article
• Grades of Recommendation for Antithrombotic Agents  Academic Article
• Grading quality of evidence and strength of recommendations for diagnostic tests and strategies  Academic Article
• Grading the evidence: Levels of evidence and grades of recommendation  Academic Article
• Gross motor performance measure for children with cerebral palsy: study design and preliminary findings.  Academic Article
• Group Intervention Studies in the Cognitive Rehabilitation of Individuals with Traumatic Brain Injury: Challenges Faced by Researchers  Academic Article
• Guideline conflict of interest management and methodology heavily impacts on the strength of recommendations: comparison between two iterations of the American College of Chest Physicians Antithrombotic Guidelines.  Academic Article
• Guidelines for Health Technology Assessment  Academic Article
• Guidelines for Monitoring Efficacy and Toxicity Responses in Clinical Trials  Academic Article
• Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed  Academic Article
• Guidelines for reading literature reviews.  Academic Article
• Guidelines for the clinical and economic evaluation of health care technologies  Academic Article
• HIV prevention in favour of the choice-disabled in southern Africa: study protocol for a randomised controlled trial  Academic Article
• HYEs: Do We Need Them and Can They Fulfil the Promise?  Academic Article
• Hacia una adecuada implementación de las guías de práctica clínica  Academic Article
• Handling trial participants with missing outcome data when conducting a meta-analysis: a systematic survey of proposed approaches  Academic Article
• Health Status Measures: Strategies and Analytic Methods for Assessing Change Scores  Academic Article
• Health-Related Quality of Life and Cost-Effectiveness Components of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial: Rationale and Design  Academic Article
• Helical Computed Tomography and the Diagnosis of Pulmonary Embolism  Academic Article
• Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia  Academic Article
• Helicobacter pylori test and treat strategy for young dyspeptic patients: new data  Conference Paper
• Hi! How are you? Response shift, implicit theories and differing epistemologies.  Academic Article
• Hierarchy of Evidence: From Case Reports to Randomized Controlled Trials  Academic Article
• Hierarchy of Evidence: Where Observational Studies Fit in and Why We Need Them  Academic Article
• High Oxygen Delivery to Preserve Exercise Capacity in Patients with Idiopathic Pulmonary Fibrosis Treated with Nintedanib. Methodology of the HOPE-IPF Study  Academic Article
• High levels of uPA and PAI-1 predict a good response to anthracyclines  Academic Article
• Hip Fracture and Proton Pump Inhibitor Therapy: Position Statement  Academic Article
• Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): protocol for a multicentre randomised trial  Academic Article
• Hormone replacement therapy: a time for pause.  Academic Article
• Hospital Selection for Unit Cost Estimates in Multicentre Economic Evaluations  Academic Article
• Hostility and Recidivism in Sexual Offenders  Academic Article
• How Many Patients? How Many Limbs? Analysis of Patients or Limbs in the Orthopaedic Literature: A Systematic Review  Academic Article
• How Should Results from Completed Studies Influence Ongoing Clinical Trials?  Academic Article
• How Strong Is the Evidence?  Academic Article
• How can diagnostic assessment programs be implemented to enhance inter-professional collaborative care for cancer?  Academic Article
• How many, powerfully?  Academic Article
• How much science is there in injury prevention and control?  Academic Article
• How qualitative research can contribute to research in the intensive care unit  Academic Article
• How to Appraise the Effectiveness of Treatment  Academic Article
• How to Design a Good Case Series  Academic Article
• How to Keep Up with the Medical Literature: I. Why Try to Keep Up and How to Get Started  Academic Article
• How to Report and Interpret Screening Test Properties: Guidelines for Driving Researchers  Academic Article
• How to Use a Randomized Clinical Trial Addressing a Surgical Procedure  Academic Article
• How to Use a Subgroup Analysis  Academic Article
• How to Use an Article About Quality Improvement  Academic Article
• How to Use an Article Reporting a Multiple Treatment Comparison Meta-analysis  Academic Article
• How to assess a survey in surgery  Academic Article
• How to conduct a high-quality systematic review on diagnostic research topics  Academic Article
• How to critique qualitative research articles.  Academic Article
• How to generalize efficacy results of randomized trials: recommendations based on a systematic review of possible approaches  Academic Article
• How to increase the value of randomised trials in COPD research  Academic Article
• How to optimize participant retention and complete follow-up in surgical research  Academic Article
• How to use an article on therapy or prevention  Academic Article
• How to use diagnostic test articles in the intensive care unit  Academic Article
• How to work with a subgroup analysis.  Academic Article
• How well are journal and clinical article characteristics associated with the journal impact factor? a retrospective cohort study  Academic Article
• Human Laboratory Paradigms in Alcohol Research  Academic Article
• Human Papillomavirus Triage of Atypical Squamous Cells of Undetermined Significance: Cost-Effective, But At What Cost?  Academic Article
• Human Subjects Protection: An Event Monitoring Committee for Research Studies of Girls From Breast Cancer Families  Academic Article
• Hyperplastic effects of aerosolized sodium metabisulfite on rat airway mucus-secretory epithelial cells  Academic Article
• Hypothermia Pediatric Head Injury Trial: The Value of a Pretrial Clinical Evaluation Phase  Academic Article
• Hypothesis testing in clinical and basic science research  Academic Article
• Identifying and understanding the health and social care needs of older adults with multiple chronic conditions and their caregivers: a protocol for a scoping review  Academic Article
• Identifying genetic and environmental risk factors for chronic orofacial pain syndromes: human models.  Academic Article
• Identifying the domains of context important to implementation science: a study protocol  Academic Article
• Immediate vs. delayed insertion of intrauterine contraception after second trimester abortion: study protocol for a randomized controlled trial  Academic Article
• Impact of Sex on Cardiovascular Outcome in Patients at High Cardiovascular Risk  Academic Article
• Impact of a Genetic Risk Score on Myocardial Infarction Risk Across Different Ethnic Populations  Academic Article
• Impact of a new course on students' potential behaviour on encountering ethical dilemmas  Academic Article
• Impact of cause of death adjudication on the results of the European prostate cancer screening trial  Academic Article
• Impact of emergency department probiotic treatment of pediatric gastroenteritis: study protocol for the PROGUT (Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment) randomized controlled trial  Academic Article
• Impact of point-of-care diagnostics on maternal outcomes in HIV-infected women: systematic review and meta-analysis protocol  Academic Article
• Impact of the Surgical Research Methodology Program on Surgical Residents’ Research Profiles  Academic Article
• Implementing health research through academic and clinical partnerships: a realistic evaluation of the Collaborations for Leadership in Applied Health Research and Care (CLAHRC)  Academic Article
• Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial  Academic Article
• Improving the Quality of Abstract Reporting for Phase I Cancer Trials  Academic Article
• Improving the reporting of pragmatic trials: an extension of the CONSORT statement  Academic Article
• Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk  Academic Article
• In Search of Power and Significance: Issues in the Design and Analysis of Stochastic Cost-Effectiveness Studies in Health Care  Academic Article
• In the dark The reporting of blinding status in randomized controlled trials  Academic Article
• Inconsistent definitions for intention-to-treat in relation to missing outcome data: systematic review of the methods literature  Academic Article
• Incorporating Documents Into Qualitative Nursing Research  Academic Article
• Incorporating edoxaban into the choice of anticoagulants for atrial fibrillation  Academic Article
• Increased Eligibility for Treatment of Chronic Hepatitis C Infection with Shortened Duration of Therapy: Implications for Access to Care and Elimination Strategies in Canada  Academic Article
• Increased levels of adipokines in bipolar disorder  Academic Article
• Independent design and conduct of clinical trials  Academic Article
• Indirect comparison: relative risk fallacies and odds solution  Academic Article
• Individuals with diabetes preferred that future trials use patient-important outcomes and provide pragmatic inferences  Academic Article
• Industry-sponsored research  Academic Article
• Infertility:Treatment of male infertility: is it effective? Review and meta-analyses of published randomized controlled trials  Academic Article
• Influence of statistician involvement on reporting of randomized clinical trials in medical oncology  Academic Article
• Influencing advance directive completion rates in non-terminally ill patients: a systematic review  Academic Article
• Influenza vaccines licensed in the United States in healthy children: a systematic review and network meta-analysis (Protocol)  Academic Article
• Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design  Academic Article
• Innovation and placebos in research: a new design of clinical trial  Academic Article
• Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas  Academic Article
• Instructional Design Variations in Internet-Based Learning for Health Professions Education: A Systematic Review and Meta-Analysis  Academic Article
• Insulin therapy in acute coronary syndromes: an appraisal of completed and ongoing randomised trials with important clinical end points  Academic Article
• Integrated collaborative care teams to enhance service delivery to youth with mental health and substance use challenges: protocol for a pragmatic randomised controlled trial  Academic Article
• Integrating community-based health promotion programs and primary care: a mixed methods analysis of feasibility  Academic Article
• Interactive weekly mobile phone text messaging plus motivational interviewing in promotion of breastfeeding among women living with HIV in South Africa: study protocol for a randomized controlled trial  Academic Article
• Interim Analyses in 2 x 2 Crossover Trials  Academic Article
• Intermittent versus continuous oxygen saturation monitoring for infants hospitalised with bronchiolitis: study protocol for a pragmatic randomised controlled trial.  Academic Article
• International law’s effects on health and its social determinants: protocol for a systematic review, meta-analysis, and meta-regression analysis  Academic Article
• International longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD)  Academic Article
• Interpretation and inference: towards an understanding of methods  Academic Article
• Interpretation of relative effects  Academic Article
• Interpreting trial sequential analysis  Academic Article
• Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a protocol for a scoping review of the literature and international policies  Academic Article
• Intracranial and fatal bleeding according to indication for long-term oral anticoagulant therapy  Academic Article
• Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial  Academic Article
• Intrathecal hyperbaric versus isobaric bupivacaine for adult non-caesarean-section surgery: systematic review protocol  Academic Article
• Intravenous immunoglobulin in Rh hemolytic disease of newborn.  Academic Article
• Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis  Academic Article
• Investigator experiences with financial conflicts of interest in clinical trials  Academic Article
• Is NNT now the number needed to traumatize?  Academic Article
• Is There an Association between STARD Statement Adherence and Citation Rate?  Academic Article
• Is a Subgroup Claim Believable?  Academic Article
• Is a subgroup effect believable? Updating criteria to evaluate the credibility of subgroup analyses  Academic Article
• Is funding source related to study reporting quality in obesity or nutrition randomized control trials in top-tier medical journals?  Academic Article
• Is there a benefit of low-dose aspirin in assisted reproduction?  Academic Article
• Is there a place for the crossover design in infertility trials?  Academic Article
• Is there a role for physician involvement in introducing research to surrogate decision makers in the intensive care unit? (The Approach trial: a pilot mixed methods study)  Academic Article
• Is there really misuse and abuse of dabigatran?  Academic Article
• Issues for reporting results  Academic Article
• Issues in the planning and conduct of randomised trials  Academic Article
• Issues of Cost and Efficiency in the Design of Reliability Studies  Academic Article
• Joint WFH-ISTH session: issues in clinical trial design  Academic Article
• Justifying the number of animals for each experiment  Academic Article
• Key design considerations for adaptive clinical trials: a primer for clinicians  Academic Article
• Key gaps in pathologic reporting for appendiceal mucinous neoplasms: time for universal synoptic reporting?  Academic Article
• LCLUC as an entry point for transdisciplinary research – Reflections from an agriculture land use change study in South Asia  Academic Article
• La formulación de recomendaciones en salud: el sistema GRADE  Academic Article
• Lack of Diversity in Orthopaedic Trials Conducted in the United States  Academic Article
• Large Sample Formulae for the Expected Number of Matches in a Category Matched Design  Academic Article
• Learning from failure-rationale and design for a study about discontinuation of randomized trials (DISCO study)  Academic Article
• Learning what to expect: context-specific control over intertrial priming effects in singleton search  Academic Article
• Leaving nothing to chance: how to randomize a clinical trial  Academic Article
• Left Atrial Appendage Occlusion Study (LAAOS): A randomized clinical trial of left atrial appendage occlusion during routine coronary artery bypass graft surgery for long-term stroke prevention  Academic Article
• Lessons learned from a resident-led clinical trial in obstetrics  Academic Article
• Level of Evidence in Orthopaedic Journals  Academic Article
• Level of clinical evidence presented at the Society for Vascular Surgery Annual Meeting during a 5-year period (2012-2016)  Academic Article
• Lipid lowering for primary prevention  Academic Article
• Local estimates of population attributable risk  Academic Article
• Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies  Academic Article
• Long-Term Predictive Validity of the Risk Matrix 2000  Academic Article
• Long-term risk of recurrence after discontinuing anticoagulants for a first unprovoked venous thromboembolism: protocol for a systematic review and meta-analysis  Academic Article
• Looking for the evidence: a systematic review of prevention strategies addressing sport and recreational injury among children and youth  Academic Article
• Low-molecular-weight heparins and unfractionated heparin in the treatment of patients with acute venous thromboembolism: Results of a meta-analysis  Academic Article
• Lowering of Glucose in Critical care: a randomized pilot trial  Academic Article
• Lymphedema in women with breast cancer: characteristics of patients screened for a randomized trial  Academic Article
• MAST and IV infusion: Do they help in prehospital trauma management?  Academic Article
• Maelstrom Research guidelines for rigorous retrospective data harmonization  Academic Article
• Magnetic Resonance Imaging Abnormalities and Psychiatric Illness  Academic Article
• Making Decisions About Prognosis in Evidence-Based Practice  Academic Article
• Making sense of quality-of-life data.  Academic Article
• Male participation in prevention programmes of mother to child transmission of HIV: a protocol for a systematic review to identify barriers, facilitators and reported interventions  Academic Article
• Management of chronic neuropathic pain: a protocol for a multiple treatment comparison meta-analysis of randomised controlled trials  Academic Article
• Management of persistent postconcussion symptoms in youth: a randomised control trial protocol  Academic Article
• Manual therapy for mechanical neck disorders: a systematic review  Academic Article
• Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial  Academic Article
• McMaster Premium LiteratUre Service (PLUS) performed well for identifying new studies for updated Cochrane reviews  Academic Article
• Measurement of actions of care-providers in long-term care  Academic Article
• Measurement of health status  Academic Article
• Measures assessing attributes of evidence-informed decision-making (EIDM) competence among nurses: a systematic review protocol  Academic Article
• Measuring and Understanding Treatment Effectiveness in Hand Surgery  Academic Article
• Measuring asthma control in group studies: do we need airway calibre and rescue β2-agonist use?  Academic Article
• Measuring the reliability of clinical data: the case for using three observers.  Academic Article
• Measuring the wellbeing of family caregivers using the time trade-off technique  Academic Article
• Medicine in the Popular Press: The Influence of the Media on Perceptions of Disease  Academic Article
• Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol  Academic Article
• Mental Health Supplement to the Ontario Health Survey: Methodology  Academic Article
• Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?  Academic Article
• Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori.  Academic Article
• Meta-analysis: Can We Mix Apples and Oranges?  Academic Article
• Metered-Dose Inhaler Accessory Devices in Acute Asthma  Academic Article
• Method and reporting quality in health professions education research: a systematic review  Academic Article
• Methodologic Issues in Health Informatics Trials: The Complexities of Complex Interventions  Conference Paper
• Methodologic issues in trials of antiemetics.  Academic Article
• Methodologic problems in clinical trials in heart failure  Academic Article
• Methodological Issues in Systematic Reviews and Meta-Analyses of Observational Studies in Orthopaedic Research  Academic Article
• Methodological and Epistemological Considerations in Utilizing Qualitative Inquiry to Develop Interventions  Academic Article
• Methodological challenges in coping and adaptation research.  Academic Article
• Methodological factors in studying medical graduates: a review of six internship performance studies.  Academic Article
• Methodological idiosyncracies, frameworks and challenges of non-pharmaceutical and non-technical treatment interventions  Academic Article
• Methodological issues in infertility research  Academic Article
• Methodological problems in studies of burn survivors and their psychosocial prognosis  Academic Article
• Methodological problems in the retrospective computation of responsiveness to change: The lesson of Cronbach  Academic Article
• Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol  Academic Article
• Methodology for Randomized Trials of Patients With Nonvariceal Upper Gastrointestinal Bleeding: Recommendations From an International Consensus Conference  Academic Article
• Methodology of the 2009 Survey on Living with Chronic Diseases in Canada--hypertension component.  Academic Article
• Methods for the analysis of bleeding outcomes in randomized trials of PLT transfusion triggers  Academic Article
• Methods to convert continuous outcomes into odds ratios of treatment response and numbers needed to treat: meta-epidemiological study  Academic Article
• Methods, applications, interpretations and challenges of interrupted time series (ITS) data: protocol for a scoping review  Academic Article
• Mine Is Bigger Than Yours  Academic Article
• Minimal dataset for post-registration surveillance of new drugs in hemophilia: communication from the SSC of the ISTH  Academic Article
• Misclassification of Case-Control Studies in Neurosurgery and Proposed Solutions  Academic Article
• Misleading hepatitis B test results due to intravenous immunoglobulin administration: implications for a clinical trial of rituximab in immune thrombocytopenia  Academic Article
• Missing data in longitudinal studies: cross-sectional multiple imputation provides similar estimates to full-information maximum likelihood  Academic Article
• Misspecification of Cox regression models with composite endpoints  Academic Article
• Mixed Methods Immigrant Mental Health Research in Canada: A Systematic Review  Academic Article
• Modelling heterogeneity variances in multiple treatment comparison meta-analysis – Are informative priors the better solution?  Academic Article
• Models of care for post-treatment follow-up of adult cancer survivors: a systematic review and quality appraisal of the evidence  Academic Article
• Monitoring the ACTIVE-W trial: Some issues in monitoring a noninferiority trial  Academic Article
• Monitoring the randomized trials of the Women's Health Initiative: the experience of the Data and Safety Monitoring Board  Academic Article
• More Informative Abstracts Revisited*  Academic Article
• More effective and less expensive: lessons from five studies examining community approaches to care  Academic Article
• Mortality and indicators of traffic-related air pollution  Academic Article
• Mothers and daughters from breast cancer families: a qualitative study of their perceptions of risks and benefits associated with minor's participation in genetic susceptibility research.  Academic Article
• Moving forward through consensus: protocol for a modified Delphi approach to determine the top research priorities in the field of orthopaedic oncology  Academic Article
• Moving from evidence to developing recommendations in guidelines: article 11 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report  Academic Article
• Moving promising research findings to the clinic: Methodological issues in the design and conduct of clinical trials of retinoids  Academic Article
• MovingU: A prospective cohort study to understand behavioural and environmental contexts influencing physical activity during the transition into emerging adulthood  Academic Article
• Multicenter Collaboration in Observational Research: Improving Generalizability and Efficiency  Academic Article
• Multicenter Study of General Anesthesia. I. Design and Patient Demography  Academic Article
• Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids-DOTT trial): pilot/feasibility phase findings  Academic Article
• Multilevel Modelling of Hierarchical Data in Developmental Studies  Academic Article
• Multilevel health promotion research: conceptual and analytical considerations.  Academic Article
• N of 1 randomized trials for investigating new drugs  Academic Article
• N of 1 randomized trials: a commentary  Academic Article
• NSAID and oesophageal adenocarcinoma: randomised trials needed to correct for bias  Academic Article
• National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report  Academic Article
• NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol  Academic Article
• Need for a large randomized trial to evaluate the effects of digitalis on morbidity and mortality in congestive heart failure  Academic Article
• Neonatal Thrombosis: Are We Doing the Right Studies?  Academic Article
• Neuromuscular Electrical Stimulation for Intensive Care Unit-Acquired Weakness: Protocol and Methodological Implications for a Randomized, Sham-Controlled, Phase II Trial  Academic Article
• Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review  Academic Article
• New measure of parental asthma management for school-age children  Academic Article
• New oral anticoagulants for stroke prevention in atrial fibrillation: impact of study design, double counting and unexpected findings on interpretation of study results and conclusions  Academic Article
• New strategies for clinical trials in patients with sepsis and septic shock  Academic Article
• Night-time intra-oesophageal bile and acid exposure in GERD patients failing PPI therapy  Academic Article
• Nitrous oxide and perioperative cardiac morbidity (ENIGMA-II) Trial: Rationale and design  Academic Article
• No surgical innovation without evaluation: the IDEAL recommendations  Academic Article
• Non-inferiority trial design for recurrent events  Academic Article
• North American Vasovagal Pacemaker Study: Study Design and Organization  Academic Article
• Nortriptyline in knee osteoarthritis (NortIKA Study): study protocol for a randomised controlled trial  Academic Article
• Nutrition and Physical Activity and Chronic Disease Prevention: Research Strategies and Recommendations  Academic Article
• OVER THE FENCE  Academic Article
• Observational Studies in Orthopaedic Surgery: The STROBE Statement as a Tool for Transparent Reporting  Academic Article
• Obtaining medically meaningful answers from an overview of randomized clinical trials  Academic Article
• Occupational back pain -- an unhelpful polemic  Academic Article
• On the need for observational studies to design and interpret randomized trials in ICU patients: a case study in stress ulcer prophylaxis  Academic Article
• Ontario Child Health Study  Academic Article
• Opioids for chronic non-cancer pain: a protocol for a systematic review of randomized controlled trials  Academic Article
• Optic nerve sheath diameter sonography for the diagnosis of increased intracranial pressure: a systematic review and meta-analysis protocol  Academic Article
• Optimal Chemotherapy for Women With Breast Cancer: The Plot Thickens  Academic Article
• Optimal Global Value of Information Trials: Better Aligning Manufacturer and Decision Maker Interests and Enabling Feasible Risk Sharing  Academic Article
• Optimal allocation of participants for the estimation of selection, preference and treatment effects in the two-stage randomised trial design  Academic Article
• Optimal clinical trial design using value of information methods with imperfect implementation  Academic Article
• Optimal search strategies for detecting health services research studies in MEDLINE  Academic Article
• Optimization of biomolecule separation by combining microscale filtration and design-of-experiment methods  Academic Article
• Optimizing Terminology for Stroke Motor Rehabilitation: Recommendations From the American Congress of Rehabilitation Medicine Stroke Movement Interventions Subcommittee  Academic Article
• Oral steroids for the resolution of otitis media with effusion (OME) in children (OSTRICH): study protocol for a randomised controlled trial  Academic Article
• Osteoarthritis antirheumatic drug trials. I. Effects of standardization procedures on observer dependent outcome measures.  Academic Article
• Osteoarthritis antirheumatic drug trials. II. Tables for calculating sample size for clinical trials.  Academic Article
• Outcome Instruments: Rationale for Their Use  Academic Article
• Outcome Measures and Implications for Sample-Size Calculations  Academic Article
• Outcome Measures in Rheumatology - Interventions for medication Adherence (OMERACT-Adherence) Core Domain Set for Trials of Interventions for Medication Adherence in Rheumatology: 5 Phase Study Protocol  Academic Article
• Outcomes after corrective surgery for congenital dextro-transposition of the great arteries using the arterial switch technique: a protocol for a scoping systematic review  Academic Article
• Outcomes for patients with the same disease treated inside and outside of randomized trials: a systematic review and meta-analysis  Academic Article
• Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review  Academic Article
• Ovarian ablation as adjuvant therapy for early-stage breast cancer.  Academic Article
• Overcoming the limitations of current meta-analysis of randomised controlled trials  Academic Article
• Overstated Conclusions of a Pooled Analysis of Bevacizumab in Colon Cancer  Academic Article
• Overview of results of randomized clinical trials in heart disease. I. Treatments following myocardial infarction  Academic Article
• Overview of the DIG trial  Academic Article
• PATIENT-REPORTED OUTCOMES IN RARE LYSOSOMAL STORAGE DISEASES: KEY INFORMANT INTERVIEWS AND A SYSTEMATIC REVIEW PROTOCOL  Academic Article
• PRISMA harms checklist: improving harms reporting in systematic reviews  Academic Article
• PRISMA-Children (C) and PRISMA-Protocol for Children (P-C) Extensions: a study protocol for the development of guidelines for the conduct and reporting of systematic reviews and meta-analyses of newborn and child health research  Academic Article
• PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan  Academic Article
• Parallel experience: how art and art theory can inform ethics in human research  Academic Article
• Parent as Proxy Reporting  Academic Article
• Participation in physical play and leisure: developing a theory- and evidence-based intervention for children with motor impairments  Academic Article
• Patient Eligibility and Trial Design for the Salvage Therapy of Advanced Urothelial Carcinoma  Academic Article
• Patient Use of Smartphones to Communicate Subjective Data in Clinical Trials  Academic Article
• Patient health outcomes in psychiatric mental health nursing  Academic Article
• Perceptions of Health Professionals on Pain in Extremely Low Gestational Age Infants  Academic Article
• Perceptions, attitudes and knowledge of evidence-based medicine in primary care in Spain: a study protocol  Academic Article
• Performance of logistic regression modeling: beyond the number of events per variable, the role of data structure  Academic Article
• Persistent methodological problems with evoked potential augmenting-reducing  Academic Article
• Perspectives on measuring participation: going forward  Academic Article
• Perturbation training to promote safe independent mobility post-stroke: study protocol for a randomized controlled trial  Academic Article
• Phase 1 Trial Design: Is 3 + 3 the Best?  Academic Article
• Phase II Stopping Rules That Employ Response Rates and Early Progression  Academic Article
• Phosphodiesterase-4 inhibition in COPD  Academic Article
• Pitfalls in the design and analysis of efficacy trials in subfertility: Associate editor's commentary: on the article 'Common statistical errors in the design and analysis of subfertility trials' by A.Vail and E.Gardner.  Academic Article
• Placebo-controlled trials:  Conference Paper
• Planned Walking and Communication in SDAT  Academic Article
• Planning and reporting of quality-of-life outcomes in cancer trials  Academic Article
• Population Survey Features and Response Rates: A Randomized Experiment  Academic Article
• Posing the research question: not so simple  Academic Article
• Position statement on ethics, equipoise and research on charged particle radiation therapy  Academic Article
• Potential Pitfall in Using Cumulative Exposure in Exposure-Response Relationships: Demonstration and Discussion  Academic Article
• Power curves  Academic Article
• Practical Model-Based Dose Finding in Early-Phase Clinical Trials  Academic Article
• Practical Research Methods for Orthopaedic Surgeons  Academic Article
• Practical research methods for orthopaedic surgeons.  Academic Article
• Pre-trial evaluation of the potential for unblinding in drug trials: A prototype example  Academic Article
• Preconditioning Shields Against Vascular Events in Surgery (SAVES), a multicentre feasibility trial of preconditioning against adverse events in major vascular surgery: study protocol for a randomised control trial  Academic Article
• Predicting and Preventing Loss to Follow-up of Adult Trauma Patients in Randomized Controlled Trials  Academic Article
• Prediction of individual combined benefit and harm for patients with atrial fibrillation considering warfarin therapy: a study protocol  Academic Article
• Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis  Academic Article
• Predictive value of the respiratory syncytial virus risk-scoring tool in the term infant in Canada  Conference Paper
• Predictors of effective bilateral subthalamic nucleus stimulation for PD  Academic Article
• Predictors of in-hospital mortality among patients with pulmonary tuberculosis: a protocol of systematic review and meta-analysis of observational studies  Academic Article
• Preference-based disease-specific health-related quality of life instrument for glaucoma: a mixed methods study protocol  Academic Article
• Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement  Academic Article
• Prefrontal cortex 5-HT2 receptors in depression: an [18F]setoperone PET imaging study.  Academic Article
• Preliminary Development and Validation of a Paediatric Cardiopulmonary Physiotherapy Discharge Tool  Academic Article
• Presentation approaches for enhancing interpretability of patient-reported outcomes (PROs) in meta-analysis: a protocol for a systematic survey of Cochrane reviews  Academic Article
• Presentation structured abstracts of proposals for clinical and epidemiological studies  Academic Article
• Preventing disease through opportunistic, rapid engagement by primary care teams using behaviour change counselling (PRE-EMPT): protocol for a general practice-based cluster randomised trial  Academic Article
• Preventing type 2 diabetes using combination therapy: design and methods of the CAnadian Normoglycaemia Outcomes Evaluation (CANOE) trial  Academic Article
• Prevention and assessment of infectious diseases among children and adult migrants arriving to the European Union/European Economic Association: A protocol for a suite of systematic reviews for public health and health systems  Academic Article
• Primary Realignment vs Suprapubic Cystostomy for the Management of Pelvic Fracture–associated Urethral Injuries: A Systematic Review and Meta-analysis  Academic Article
• Principles of Designing a Cohort Study in Orthopaedics  Academic Article
• Probiotics for infantile colic: a systematic review  Academic Article
• Problems in setting up an executing large-scale psychiatric epidemiological studies.  Academic Article
• Problems of stopping trials early  Academic Article
• Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]  Academic Article
• Prochlorperazine or Metoclopramide?  Academic Article
• Prognostic validation of a non-laboratory and a laboratory based cardiovascular disease risk score in multiple regions of the world  Academic Article
• Prognostic value of early response to chemotherapy assessed by the day 15 bone marrow aspiration in adult acute lymphoblastic leukemia: A prospective analysis of 437 cases and its application for designing induction chemotherapy trials  Academic Article
• Promoting Optimal Physical Exercise for Life (PROPEL): aerobic exercise and self-management early after stroke to increase daily physical activity—study protocol for a stepped-wedge randomised trial  Academic Article
• Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1 trial): study protocol for a pragmatic, stepped-wedge, cluster randomized controlled registry  Academic Article
• Promoting self-directed learning using a menu of assessment options: the investment model  Academic Article
• Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study  Academic Article
• Pros and Cons of Composite Endpoints in Anesthesia Trials  Academic Article
• Protein Plus Carbohydrate Does Not Enhance 60-km Time-Trial Performance  Academic Article
• Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study  Academic Article
• Protocol for a randomised trial of higher versus lower intensity patient-provider communication interventions to reduce antibiotic misuse in two paediatric ambulatory clinics in the USA.  Academic Article
• Protocol for a randomised, placebo-controlled pilot study for assessing feasibility and efficacy of faecal microbiota transplantation in a paediatric ulcerative colitis population: PediFETCh trial  Academic Article
• Protocol for determining the diagnostic validity of physical examination maneuvers for shoulder pathology  Academic Article
• Protocol for the MATCH study (Mindfulness and Tai Chi for cancer health): A preference-based multi-site randomized comparative effectiveness trial (CET) of Mindfulness-Based Cancer Recovery (MBCR) vs. Tai Chi/Qigong (TCQ) for cancer survivors  Academic Article
• Protocol for the development of a CONSORT-equity guideline to improve reporting of health equity in randomized trials  Academic Article
• Psychosocial adjustment in women with breast cancer  Academic Article
• Psychosocial impacts in populations exposed to solid waste facilities  Academic Article
• Publication bias in animal research: a systematic review protocol  Academic Article
• Q-Methodology in Nursing Research  Academic Article
• Qualitative and quantitative research methods.  Academic Article
• Qualitative case study methodology in nursing research: an integrative review  Academic Article
• Qualitative research in rehabilitation science: opportunities, challenges, and future directions  Academic Article
• Qualitative–Geospatial Methods of Exploring Person–Place Transactions in Aging Adults: A Scoping Review  Academic Article
• Quality of Reporting of Modern Randomized Controlled Trials in Medical Oncology: A Systematic Review  Academic Article
• Quality of Reporting of Randomized Controlled Trials in General Endocrinology Literature  Academic Article
• Quality of Survey Reporting in Nephrology Journals: A Methodologic Review  Academic Article
• Quality of randomized clinical trials in juvenile idiopathic arthritis  Academic Article
• Quality of reporting of surveys in critical care journals  Conference Paper
• Quantitative evaluation of single-arm versus randomized phase II cancer clinical trials  Academic Article
• Quantitative methods for estimating the number of motor units in human muscles.  Academic Article
• Quasi-experimental study designs series—paper 11: supporting the production and use of health systems research syntheses that draw on quasi-experimental study designs  Academic Article
• Quasi-experimental study designs series—paper 4: uses and value  Academic Article
• Questioning the Methodological Superiority of ‘Placebo’ over ‘Active’ Controlled Trials  Academic Article
• RCT = results confounded and trivial: the perils of grand educational experiments  Academic Article
• RE-COVERY DVT/PE: Rationale and design of a prospective observational study of acute venous thromboembolism with a focus on dabigatran etexilate  Academic Article
• Radiation Therapy Oncology Group. Research Plan 2002-2006. Gynecology Cancer Working Group.  Academic Article
• Radiographs of hip fractures were digitally altered to mask surgeons to the type of implant without compromising the reliability of quality ratings or making the rating process more difficult  Academic Article
• Random error in cardiovascular meta-analyses: How common are false positive and false negative results?  Academic Article
• Randomised trial of mitral valve repair with leaflet resection versus leaflet preservation on functional mitral stenosis (The CAMRA CardioLink-2 Trial)  Academic Article
• Randomized Clinical Trials: The Meeting Place of Medical Practice and Clinical Research  Academic Article
• Randomized Controlled Trials  Academic Article
• Randomized Controlled Trials in Long-Term Care Residents with Dementia: A Systematic Review  Academic Article
• Randomized Phase II Trials: Inevitable or Inadvisable?  Academic Article
• Randomized Trials in Critical Care Nutrition  Academic Article
• Randomized controlled trial of human papillomavirus testing versus Pap cytology in the primary screening for cervical cancer precursors: Design, methods and preliminary accrual results of the Canadian cervical cancer screening trial (CCCaST)  Academic Article
• Randomized controlled trials and neuro-oncology: should alternative designs be considered?  Academic Article
• Randomized controlled trials of herbal interventions underreport important details of the intervention  Academic Article
• Randomized trials of public health interventions reported in the Canadian Journal of Public Health: 1966 to 1996.  Academic Article
• Randomized trials published in higher vs. lower impact journals differ in design, conduct, and analysis  Academic Article
• Randomized, controlled clinical trials in sepsis: Has methodological quality improved over time?  Academic Article
• Randomizing patients by family practice: sample size estimation, intracluster correlation and data analysis  Academic Article
• Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methods  Academic Article
• Rationale and Design of the Echocardiographic Study of Hispanics/Latinos (ECHO-SOL).  Academic Article
• Rationale and Design of the Informing Fresh versus Old Red Cell Management (INFORM) Trial: An International Pragmatic Randomized Trial  Academic Article
• Rationale and design of ACTIVE: The atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events  Academic Article
• Rationale and design of AVERROES: Apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment  Academic Article
• Rationale and design of RE-LY: Randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran  Academic Article
• Rationale and design of South Asian Birth Cohort (START): a Canada-India collaborative study  Academic Article
• Rationale and design of The Coronary Artery Bypass Grafting Surgery Off or On Pump Revascularization Study: A large international randomized trial in cardiac surgery  Academic Article
• Rationale and design of XAMOS: noninterventional study of rivaroxaban for prophylaxis of venous thromboembolism after major hip and knee surgery  Academic Article
• Rationale and design of a Global Rheumatic Heart Disease Registry: The REMEDY study  Academic Article
• Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE Study. Microalbuminuria, cardiovascular, and renal outcomes. Heart Outcomes Prevention Evaluation.  Academic Article
• Rationale and design of a randomized controlled trial evaluating community health worker–based interventions for the secondary prevention of acute coronary syndromes in India (SPREAD)  Academic Article
• Rationale and design of a study assessing treatment strategies of atrial fibrillation in patients with heart failure: The Atrial Fibrillation and Congestive Heart Failure (AF-CHF) trial  Academic Article
• Rationale and design of the ATTRACT Study: A multicenter randomized trial to evaluate pharmacomechanical catheter-directed thrombolysis for the prevention of postthrombotic syndrome in patients with proximal deep vein thrombosis  Academic Article
• Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis  Academic Article
• Rationale and design of the Trial of Routine ANgioplasty and Stenting After Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction (TRANSFER-AMI)  Academic Article
• Rationale and methods of an Evaluation of the Effectiveness of the Community Paramedicine at Home (CP@home) program for frequent users of emergency medical services in multiple Ontario regions: a study protocol for a randomized controlled trial  Academic Article
• Rationale, Design and Baseline Data of a Randomized, Double-Blind, Controlled Trial Comparing Two Antithrombotic Regimens (a Fixed-Dose Combination of Extended-Release Dipyridamole plus ASA with Clopidogrel) and Telmisartan versus Placebo in Patients with Strokes: The Prevention Regimen for Effectively Avoiding Second Strokes Trial (PRoFESS)  Academic Article
• Rationale, design and organization of the Second Chinese Cardiac Study (CCS-2): a randomized trial of clopidogrel plus aspirin, and of metoprolol, among patients with suspected acute myocardial infarction. Second Chinese Cardiac Study (CCS-2) Collaborative Group.  Academic Article
• Rationale, design and organization of the delayed antibiotic prescription (DAP) trial: a randomized controlled trial of the efficacy and safety of delayed antibiotic prescribing strategies in the non-complicated acute respiratory tract infections in general practice  Academic Article
• Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: The ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention)  Academic Article
• Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo  Academic Article
• Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials  Academic Article
• Rationale, design, and baseline characteristics of a randomized trial to assess the effect of cholesterol lowering on the progression of aortic stenosis  Academic Article
• Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery  Academic Article
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• Response to paper by Lang A, Edwards N, and Fleiszer A  Academic Article
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• Six myths about controlled trials in perinatal medicine  Academic Article
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• Sources of bias in diagnostic accuracy studies and the diagnostic process  Academic Article
• Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid  Academic Article
• Stakeholder Engagement in Trial Design: Survey of Visitors to Critically Ill Patients Regarding Preferences for Outcomes and Treatment Options during Weaning from Mechanical Ventilation  Academic Article
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• Standards of Proof, Standards of Practice, and Proof of Standards: A Tale of Two Trials  Academic Article
• Starting prophylaxis for venous thromboembolism postoperatively  Academic Article
• Statistical approaches to harmonize data on cognitive measures in systematic reviews are rarely reported  Academic Article
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• Statistical methodologies to pool across multiple intervention studies  Academic Article
• Statistical significance and fragility criteria for assessing a difference of two proportions  Academic Article
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• Steroid use in critically ill septic patients: acknowledging the uncertainty.  Academic Article
• Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial  Academic Article
• Steroids and Spinal Cord Injury  Academic Article
• Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial  Academic Article
• Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials  Academic Article
• Strategic use of new generation antidepressants for depression: SUN(^_^) D protocol update and statistical analysis plan  Academic Article
• Strategies and Methods for Research on Sex Differences in Brain and Behavior  Academic Article
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• Stress Physiology in Infancy and Early Childhood: Cortisol Flexibility, Attunement and Coordination  Academic Article
• Student-designed clinical trials: evaluating self-directed learning in pharmacology  Academic Article
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• Study Design for the Evaluation of Diagnostic Tests  Academic Article
• Study design attributes influenced patients' willingness to participate in clinical research: a randomized vignette-based study  Academic Article
• Study protocol for a randomized, controlled, superiority trial comparing the clinical and cost- effectiveness of integrated online mental health assessment-referral-care in pregnancy to usual prenatal care on prenatal and postnatal mental health and infant health and development: the Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT)  Academic Article
• Study protocol for multicentre randomized controlled trial of HeLP (Heat Loss Prevention) in the delivery room  Academic Article
• Study protocol for the Balanced Solution versus Saline in Intensive Care Study (BaSICS): a factorial randomised trial.  Academic Article
• Study protocol: a systematic review of pediatric shared decision making  Academic Article
• Study protocol: pragmatic randomized control trial of an internet-based intervention (My tools 4 care) for family carers  Academic Article
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• Studying the Emergence of Autism Spectrum Disorders in High-risk Infants: Methodological and Practical Issues  Academic Article
• Subcutaneous IGF-1 is not beneficial in 2-year ALS trial  Academic Article
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• Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications  Academic Article
• Suggesting the Optimal Control Procedure for Acupressure Studies  Academic Article
• Supported housing programs for persons with serious mental illness in rural northern communities: A mixed method evaluation  Academic Article
• Supporting Physical Activity in the Childcare Environment (SPACE): rationale and study protocol for a cluster randomized controlled trial  Academic Article
• Supporting successful implementation of public health interventions: protocol for a realist synthesis  Academic Article
• Supporting the improvement and management of prescribing for urinary tract infections (SIMPle): protocol for a cluster randomized trial  Academic Article
• Surgical ablation of atrial fibrillation: a protocol for a systematic review and meta-analysis of randomised controlled trials  Academic Article
• Surgical versus Nonsurgical Treatment for Back Pain  Academic Article
• Survey Design in Orthopaedic Surgery: Getting Surgeons to Respond  Academic Article
• Surveys are important research tools.  Academic Article
• Survival Analysis  Academic Article
• Survival distributions impact the power of randomized placebo-phase design and parallel groups randomized clinical trials  Academic Article
• Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial  Academic Article
• Symptom-onset dosing with citalopram in the treatment of premenstrual dysphoric disorder (PMDD): a case series  Academic Article
• Synthesizing Evidence  Academic Article
• Systematic Review on Hormone Receptor Testing in Breast Cancer  Academic Article
• Systematic Review: Efficacy and Safety of Rituximab for Adults with Idiopathic Thrombocytopenic Purpura  Academic Article
• Systematic Reviews: The Good, the Bad and the Ugly  Academic Article
• Systematic evaluation of the methodology of randomized controlled trials of anticoagulation in patients with cancer  Academic Article
• Systematic reviewers neglect bias that results from trials stopped early for benefit  Academic Article
• Systematic reviews experience major limitations in reporting absolute effects  Academic Article
• Systematic reviews identify important methodological flaws in stroke rehabilitation therapy primary studies: review of reviews  Academic Article
• Systematic reviews of observational studies of risk of thrombosis and bleeding in urological surgery (ROTBUS): introduction and methodology  Academic Article
• Systematic reviews supporting practice guideline recommendations lack protection against bias  Academic Article
• Systematic reviews: the case for rigorous methods and rigorous reporting  Academic Article
• TEACH: Trial of Education And Compliance in Heart dysfunction chronic disease and heart failure (HF) as an increasing problem  Academic Article
• THE FEASIBILITY OF MATCHING AND QUOTA SAMPLING IN EPIDEMIOLOGIC STUDIES  Academic Article
• THE QUALITY OF REPORTING OF RANDOMIZED TRIALS IN THE JOURNAL OF BONE AND JOINT SURGERY FROM 1988 THROUGH 2000  Academic Article
• Teaching Evidence-Based Complementary and Alternative Medicine: 2. A Conceptual Approach to Causation—Part 1  Academic Article
• Teaching Evidence-Based Complementary and Alternative Medicine: 2. A Conceptual Approach to Causation—Part 2  Academic Article
• Technology in medicine -- ethics, politics and reality.  Academic Article
• Termination of a randomized controlled trial of two vasectomy techniques  Academic Article
• Testing Quality Improvement Interventions  Academic Article
• Testing a tool for the classification of study designs in systematic reviews of interventions and exposures showed moderate reliability and low accuracy  Academic Article
• The 2014 Survey on Living with Chronic Diseases in Canada on Mood and Anxiety Disorders: a methodological overview  Academic Article
• The ACHRU-CPP versus usual care for older adults with type-2 diabetes and multiple chronic conditions and their family caregivers: study protocol for a randomized controlled trial  Academic Article
• The AGREE Reporting Checklist: a tool to improve reporting of clinical practice guidelines  Academic Article
• The Abandoned Trials of Pre-Exposure Prophylaxis for HIV: What Went Wrong?  Academic Article
• The Aetiology of Sport Injuries  Academic Article
• The Age of Blood Evaluation (ABLE) Randomized Controlled Trial: Study Design  Academic Article
• The Argentinian mother-and-child contaminant study: a cross-sectional study among delivering women in the cities of Ushuaia and Salta  Academic Article
• The Bipolar Illness Onset study: research protocol for the BIO cohort study  Academic Article
• The CHADS2 score for stroke risk stratification in atrial fibrillation – friend or foe?  Academic Article
• The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: a double-blind, placebo-controlled trial in patients with esrd.  Academic Article
• The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study  Academic Article
• The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in Response Prediction  Academic Article
• The Canadian Maternity Experiences Survey: Design and Methods  Academic Article
• The Chest Pain Choice trial: a pilot randomized trial of a decision aid for patients with chest pain in the emergency department  Academic Article
• The Choice of Normative Pediatric Reference Database Changes Spine Bone Mineral Density Z-Scores But Not the Relationship Between Bone Mineral Density and Prevalent Vertebral Fractures  Academic Article
• The Completeness of Reporting (CORE) index identifies important deficiencies in observational study conference abstracts  Academic Article
• The Consolidated Standards of Reporting Trials (CONSORT) Statement applied to allergen-specific immunotherapy with inhalant allergens: A Global Allergy and Asthma European Network (GA2LEN) article  Academic Article
• The Coordination and Activity Tracking in CHildren (CATCH) study: rationale and design  Academic Article
• The Defibrillator in Acute Myocardial Infarction Trial (DINAMIT): Rationale, Design and Specific Aims  Academic Article
• The Defibrillator in Acute Myocardial Infarction Trial (DINAMIT): Study protocol  Academic Article
• The Design of Randomized Clinical Trials in Critically Ill Patients  Academic Article
• The Efficacy of Leukodepletion to Improve Platelet Transfusion Response: A Critical Appraisal of Clinical Studies  Academic Article
• The Estimation and Interpretation of Attributable Risk in Health Research  Academic Article
• The Ethical Conduct of Clinical Research Involving Critically Ill Patients in the United States and Canada  Academic Article
• The Fluid Study Protocol: A Randomized Controlled Study on the Effects of Bioimpedance Analysis and Vitamin D on Left Ventricular Mass in Peritoneal Dialysis Patients  Academic Article
• The GRADE approach is reproducible in assessing the quality of evidence of quantitative evidence syntheses  Academic Article
• The HOPE (Heart Outcomes Prevention Evaluation) Study: the design of a large, simple randomized trial of an angiotensin-converting enzyme inhibitor (ramipril) and vitamin E in patients at high risk of cardiovascular events. The HOPE study investigators.  Academic Article
• The Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth): design, objectives, and procedures  Academic Article
• The Importance and Challenges of Dietary Intervention Trials for Inflammatory Bowel Disease  Academic Article
• The Importance of Reporting Patient Recruitment Details in Phase III Trials  Academic Article
• The Incidence of Injuries in Young People: I Methodology and Results of a Collaborative Study in Brazil, Chile, Cuba and Venezuela  Academic Article
• The Inclusion of Minority Groups in Clinical Trials: Problems of Under Representation and Under Reporting of Data  Academic Article
• The Influence of Display and Statistical Factors on the Interpretation of Metaanalysis Results by Physicians  Academic Article
• The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) Study  Academic Article
• The JDRF CCTN CGM TIME Trial: Timing of Initiation of continuous glucose Monitoring in Established pediatric type 1 diabetes: study protocol, recruitment and baseline characteristics  Academic Article
• The MACTAR Patient Preference Disability Questionnaire--an individualized functional priority approach for assessing improvement in physical disability in clinical trials in rheumatoid arthritis.  Academic Article
• The Need for Large Clinical Studies in Perioperative Medicine  Academic Article
• The Neighbourhood Effects on Health and Well-being (NEHW) study  Academic Article
• The Northern Norway mother-and-child contaminant cohort study: implementation, population characteristics and summary of dietary findings  Academic Article
• The Number of Patients and Events Required to Limit the Risk of Overestimation of Intervention Effects in Meta-Analysis—A Simulation Study  Academic Article
• The Ontario Mother and Infant Study (TOMIS) III: A multi-site cohort study of the impact of delivery method on health, service use, and costs of care in the first postpartum year  Academic Article
• The PRECISE RCT: Evolution of an Early Septic Shock Fluid Resuscitation Trial  Academic Article
• The Quality Initiative in Rectal Cancer (QIRC) trial: study protocol of a cluster randomized controlled trial in surgery  Academic Article
• The Quality of Reporting of Orthopaedic Randomized Trials with Use of a Checklist for Nonpharmacological Therapies  Academic Article
• The Reporting of Clinical Acupuncture Research: What Do Clinicians Need to Know?  Academic Article
• The Role of Integrated Knowledge Translation in Intervention Research  Academic Article
• The Scholarly Influence of Orthopaedic Research According to Conventional and Alternative Metrics  Academic Article
• The Secondary Prevention of Small Subcortical Strokes (SPS3) Study  Academic Article
• The Study of Health Assessment and Risk in Ethnic groups (SHARE): rationale and design. The SHARE Investigators.  Academic Article
• The TRIPSE: A process-oriented exam for large undergraduate classes  Academic Article
• The Tactics of Large Randomized Trials  Academic Article
• The Treatment of Heart Failure  Academic Article
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• The Use of Cost-effectiveness Analysis in Plastic Surgery Clinical Research  Academic Article
• The Use of Triangulation in Qualitative Research  Academic Article
• The Value of Value of Information  Academic Article
• The Warfarin and Antiplatelet Therapy in Heart Failure Trial (WATCH): rationale, design, and baseline patient characteristics  Academic Article
• The aetiology, consequences and prevention of barotrauma: a critical review of the literature  Academic Article
• The analysis of treatment effects for recurring episodic conditions  Academic Article
• The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods  Academic Article
• The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy  Academic Article
• The design and analysis of randomized trials with recurrent events  Academic Article
• The development and validation of a novel questionnaire to measure patient and family satisfaction with end-of-life care: the Canadian Health Care Evaluation Project (CANHELP) Questionnaire  Academic Article
• The effect of auricular acupuncture on anaesthesia: a search for optimal design  Academic Article
• The effect of dornase alfa on ventilation inhomogeneity in patients with cystic fibrosis  Academic Article
• The effect of loss to follow-up on treatment of blunt traumatic thoracic aortic injury  Academic Article
• The effect of psychological interventions on the prevention of chronic pain in adults: a systematic review protocol  Academic Article
• The effectiveness and safety of treatments used for acute diarrhea and acute gastroenteritis in children: protocol for a systematic review and network meta-analysis  Academic Article
• The effectiveness and safety of treatments used for polycystic ovarian syndrome management in adolescents: a systematic review and network meta-analysis protocol  Academic Article
• The effectiveness of a Supported Self-management task-shifting intervention for adult depression in Vietnam communities: study protocol for a randomized controlled trial  Academic Article
• The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol  Academic Article
• The efficacy and safety of glucose control algorithms in intensive care: a pilot study of the Survival Using Glucose Algorithm Regulation (SUGAR) trial  Academic Article
• The efficacy of fall-risk-increasing drug (FRID) withdrawal for the prevention of falls and fall-related complications: protocol for a systematic review and meta-analysis  Academic Article
• The end of educational science?  Academic Article
• The evolution of the randomized controlled trial and its role in evidence-based decision making  Academic Article
• The extended adjuvant NCIC CTG MA.17 trials: Initial and rerandomization studies  Academic Article
• The fox guarding the clinical trial: internal vs. external validity in randomized studies  Academic Article
• The greater involvement of people living with AIDS principle: theory versus practice in Ontario's HIV/AIDS community-based research sector  Academic Article
• The history and development of N-of-1 trials  Academic Article
• The honeypot: Sticky or sweet?  Academic Article
• The impact of chronic pain on opioid addiction treatment: a systematic review protocol  Academic Article
• The impact of deep vein thrombosis in critically ill patients: a meta-analysis of major clinical outcomes.  Academic Article
• The impact of tobacco prices on smoking onset: a methodological review  Academic Article
• The inadequacy of recent research on computer-assisted instruction  Academic Article
• The influence of study characteristics on reporting of subgroup analyses in randomised controlled trials: systematic review  Academic Article
• The keys to healthy family child care homes intervention: Study design and rationale  Academic Article
• The landscape of knowledge translation interventions in cancer control: What do we know and where to next? A review of systematic reviews  Academic Article
• The level of evidence keeps improving: An updated analysis of the scientific program at the Canadian Association of Paediatric Surgeons Annual Meeting  Conference Paper
• The need to test the theories behind the Polypill: rationale behind the Indian Polycap Study  Academic Article
• The paradox of evidence-based medicine. Commentary on Gupta (2003), A critical appraisal of evidence-based medicine: some ethical considerations.Journal of Evaluation in Clinical Practice9, 111-121  Academic Article
• The practicalists' response  Academic Article
• The practice of ‘doing’ evaluation: lessons learned from nine complex intervention trials in action  Academic Article
• The provision of medical assistance in dying: protocol for a scoping review  Academic Article
• The quality of QALYs (quality-adjusted-life-years): do QALYs measure what they at least intend to measure?  Academic Article
• The quality of randomized trial reporting in leading medical journals since the revised CONSORT statement  Academic Article
• The quality of reporting of trial abstracts is suboptimal: Survey of major general medical journals  Academic Article
• The randomized placebo-phase design for clinical trials  Academic Article
• The rationale and design of the Beta-blocker to LOwer CArdiovascular Dialysis Events (BLOCADE) Feasibility Study  Academic Article
• The relationship between basic biomedical research and the design and analysis of clinical trials  Academic Article
• The research process from ideas to implementation  Academic Article
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• The risk of elevated prolactin levels in pediatric patients exposed to antipsychotics for the treatment of schizophrenia and schizophrenia spectrum disorders: protocol for a systematic review and meta-analysis  Academic Article
• The role of before-after studies of therapeutic impact in the evaluation of diagnostic technologies  Academic Article
• The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol  Academic Article
• The role of noninferiority designs in clinical research  Academic Article
• The role of pragmatism in explaining heterogeneity in meta-analyses of randomised trials: a protocol for a cross-sectional methodological review  Academic Article
• The use of surrogate endpoints in clinical trials: focus on clinical trials in cardiovascular diseases  Academic Article
• The value of Emphasis in Eliminating Errors  Academic Article
• The value of information and optimal clinical trial design  Academic Article
• The ‘Expanded HIV care in opioid substitution treatment’ (EHOST) cluster-randomized, stepped-wedge trial: A study protocol  Academic Article
• The ‘goddess of randomisation’ in small samples  Academic Article
• The “parallel-cohort RCT”: Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism  Academic Article
• Then-of-1 Randomized Controlled Trial: Clinical Usefulness  Academic Article
• Therapeutic equivalence: all studies are not created equal.  Academic Article
• Thiazides for Patients with Recurrent Calcium Stones: Still an Open Question  Academic Article
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• Thrombolysis Compared With Heparin for the Initial Treatment of Pulmonary Embolism  Academic Article
• Thromboprophylaxis using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone in critically ill patients: study protocol for a randomized controlled trial  Academic Article
• Thrombosis prophylaxis in the acutely ill medical patient: insights from the prophylaxis in medical patients with enoxaparin (MEDENOX) trial  Academic Article
• Time and Expected Value of Sample Information Wait for No Patient  Academic Article
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• Time to rethink clinically important outcomes in platelet transfusion trials  Academic Article
• Time-dependent analysis in CHF follow-up  Academic Article
• Tips for learners of evidence-based medicine: 2. Measures of precision (confidence intervals)  Academic Article
• Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic)  Academic Article
• Tips for learners of evidence-based medicine: 4. Assessing heterogeneity of primary studies in systematic reviews and whether to combine their results  Academic Article
• Tips on overlapping confidence intervals and univariate linear models  Academic Article
• Tolerability and efficacy of docetaxel in older men with metastatic castrate-resistant prostate cancer (mCRPC) in the TAX 327 trial  Academic Article
• Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis  Academic Article
• Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus  Academic Article
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• Transesophageal Echocardiography to Guide Cardioversion in Patients with Atrial Fibrillation  Academic Article
• Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial  Academic Article
• Treating the right patient at the right time: Access to cardiovascular nuclear imaging  Academic Article
• Treatment allocation in clinical trials  Academic Article
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• Trends and recommendations in studies of mouse airway function  Academic Article
• Trends in the application of dynamic allocation methods in multi-arm cancer clinical trials  Academic Article
• Triage Tool Inter-rater Reliability: A Comparison of Live Versus Paper Case Scenarios  Academic Article
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• Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses  Academic Article
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• Two doses of rivaroxaban versus aspirin for prevention of recurrent venous thromboembolism  Academic Article
• Two-stage design of clinical trials involving recurrent events  Academic Article
• Type-II Error Rates (Beta Errors) of Randomized Trials in Orthopaedic Trauma  Academic Article
• UFFI Dust  Academic Article
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• Understanding non-inferiority trials and tests for the non-statistician: when to use them and how to interpret them  Academic Article
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