Research Design - McMaster Experts

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'Functional status of extremely preterm infants at kindergarten entry'. Academic Article
21st Century Evidence: Randomized Controlled Trials Versus Systematic Reviews and Meta-Analyses Academic Article
3D Ultrasound Measurement of Change in Carotid Plaque Volume Academic Article
Curved versusStraight Stem UncementedTotal Hip ArthroplastyOsteoarthritisMulticenter trial (CUSTOM): design of a prospective blinded randomised controlled multicentre trial: Table 1 Academic Article
Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia Academic Article
Nash-wo-Numa(childhood growth & development) study protocol: factors that impact linear growth in children 9 to 15 years of age in Matiari, Pakistan Academic Article
n-of-1 Randomized Controlled Trials: An Opportunity for Complementary and Alternative Medicine Evaluation Academic Article
A Bayesian adaptive design for clinical trials of rare efficacy outcomes with multiple definitions Academic Article
A CONTROLLED PROSPECTIVE STUDY OF THE EFFECT OF ENDURANCE TRAINING ON THE RECURRENCE RATE OF MYOCARDIAL INFARCTION Academic Article
A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial Academic Article
A Checklist for Reporting Valuation Studies of Multi-Attribute Utility-Based Instruments (CREATE) Academic Article
A Comparison of Methods for Capturing Patient Preferences for Delivery of Mental Health Services to Low-Income Hispanics Engaged in Primary Care Academic Article
A Consumer's Guide to Subgroup Analyses Academic Article
A Controlled Trial of Teaching Critical Appraisal of the Clinical Literature to Medical Students Academic Article
A Critical Analysis of Studies of State Drug Reimbursement Policies: Research in Need of Discipline Academic Article
A Meta-Analytic Review of the Effect of Exercise on Smoking Cessation Academic Article
A Method for Identifying Research Priorities for Health Systems Research on Health and Aging Academic Article
A New Class of Robust Two-Sample Wald-Type Tests Academic Article
A Pilot Feasibility Study of an Extension of the Acquaintanceship Recruitment Procedure in Recent-Onset Psychosis Academic Article
A Practical Guide to Research: Design, Execution, and Publication Academic Article
A Process for Systematically Reviewing the Literature: Providing the Research Evidence for Public Health Nursing Interventions Academic Article
A Prospective Comparison of Four Study Designs Used in Assessing Safety and Effectiveness of Drug Therapy in Hypertension Management Academic Article
A RANDOMIZED PROSPECTIVE TRIAL OF COLD STORAGE VERSUS PULSATILE PERFUSION FOR CADAVER KIDNEY PRESERVATION Academic Article
A REVIEW OF POTENTIAL METHODS OF DETERMINING CRITICAL EFFECT SIZE FOR DESIGNING ENVIRONMENTAL MONITORING PROGRAMS Academic Article
A Review and Analysis of Placebo Treatments, Placebo Effects, and Placebo Controls in Trials of Medical Procedures When Sham Is Not Inert Academic Article
A Scoring Algorithm for Deriving Utility Values from the Neuro-QoL for Patients with Multiple Sclerosis Academic Article
A Stimulated Recall Method for the Improved Assessment of Quantity and Quality of Social Media Use Academic Article
A Systematic Review of Heparin to Treat Burn Injury Academic Article
A Systematic Review of Interventions for Elder Abuse Academic Article
A Systematic Review of the Quality of Trials Evaluating Biomedical HIV Prevention Interventions Shows That Many Lack Power Academic Article
A Systematic Review of the Relationship Between Breastfeeding and Early Childhood Caries Academic Article
A brief transdiagnostic psychological intervention for Afghan asylum seekers and refugees in Austria: a randomized controlled trial Academic Article
A call for consensus in defining efficacy in clinical trials for opioid addiction: combined results from a systematic review and qualitative study in patients receiving pharmacological assisted therapy for opioid use disorder Academic Article
A clinician's guide to the assessment and interpretation of noninferiority trials for novel therapies. Academic Article
A cluster randomized controlled trial for the Evaluation of routinely Measured PATient reported outcomes in HemodialYsis care (EMPATHY): a study protocol Academic Article
A comment on Burgomaster et al. and a general plea to consider behavioral influences in human physiology studies Academic Article
A comparison of a new multinomial stopping rule with stopping rules of fleming and gehan in single arm phase II cancer clinical trials Academic Article
A comparison of dabigatran etexilate with warfarin in patients with mechanical heart valves: The Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt (RE-ALIGN) Academic Article
A comparison of meta-analytic methods for synthesizing evidence from explanatory and pragmatic trials Academic Article
A critical appraisal of bleeding events reported in venous thromboembolism prevention trials of patients undergoing hip and knee arthroplasty Academic Article
A critical review of the relationship between impaired fibrinolysis and myocardial infarction Academic Article
A double-blind, randomized controlled trial to compare the effect of biannual peripheral magnetic resonance imaging, radiography and standard of care disease progression monitoring on pharmacotherapeutic escalation in rheumatoid and undifferentiated inflammatory arthritis: study protocol for a randomized controlled trial Academic Article
A framework of operating models for interdisciplinary research programs in clinical service organizations Academic Article
A guidance was developed to identify participants with missing outcome data in randomized controlled trials Academic Article
A guide and pragmatic considerations for applying GRADE to network meta-analysis Academic Article
A guide for the performance of the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase gene mutation assay Academic Article
A guide to evaluating survey research methodology in pediatric urology Academic Article
A guide to interpreting discordant systematic reviews. Academic Article
A life needs model of pediatric service delivery: services to support community participation and quality of life for children and youth with disabilities. Academic Article
A longitudinal cohort study of symptoms and other concerns among Nigerian people with stages 3–5 chronic kidney diseases: study protocol Academic Article
A meta-research study revealed several challenges in obtaining placebos for investigator-initiated drug trials Academic Article
A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): a study protocol (vol 2, 113, 2013) Academic Article
A mixed methods evaluation of the maternal-newborn dashboard in Ontario: dashboard attributes, contextual factors, and facilitators and barriers to use: a study protocol Academic Article
A modified Delphi and cross-sectional survey to facilitate selection of optimal outcomes and measures for a systematic review on geriatrician-led care models Academic Article
A multi-centre clinical evaluation of isoflurane Academic Article
A multi-centre randomised trial to compare the effectiveness of geriatrician-led admission avoidance hospital at home versus inpatient admission Academic Article
A multinational registry to study the characteristics and outcomes of heart failure patients: The global congestive heart failure (G-CHF) registry Academic Article
A new 'Mechanistic-Practical” Framework for designing and interpreting randomized trials Academic Article
A new era in idiopathic pulmonary fibrosis: considerations for future clinical trials Academic Article
A novel training simulator for portable ultrasound identification of incorrect newborn endotracheal tube placement – observational diagnostic accuracy study protocol Academic Article
A phase II multi-institutional study assessing simultaneous in-field boost helical tomotherapy for 1-3 brain metastases Academic Article
A practical approach to evidence-based dentistry Academic Article
A practical methodology for disaggregating the drivers of drug costs using administrative data Academic Article
A practitioner's guide to developing critical appraisal skills Academic Article
A prospective evaluation of edoxaban compared to warfarin in subjects undergoing cardioversion of atrial fibrillation: The EdoxabaN vs. warfarin in subjectS UndeRgoing cardiovErsion of Atrial Fibrillation (ENSURE-AF) study Academic Article
A prospective multiple case study of the impact of emerging scientific evidence on established colorectal cancer screening programs: a study protocol Academic Article
A prospective, double-blind, randomized, controlled clinical trial comparing standard wound care with adjunctive hyperbaric oxygen therapy (HBOT) to standard wound care only for the treatment of chronic, non-healing ulcers of the lower limb in patients with diabetes mellitus: a study protocol Academic Article
A protocol for a Canadian prospective observational study of decision-making on active surveillance or surgery for low-risk papillary thyroid cancer Academic Article
A protocol for a pragmatic randomized controlled trial using the Health Teams Advancing Patient Experience: Strengthening Quality (Health TAPESTRY) platform approach to promote person-focused primary healthcare for older adults Academic Article
A protocol for a scoping review of equity measurement in mental health care for children and youth Academic Article
A protocol for a systematic review on the impact of unpublished studies and studies published in the gray literature in meta-analyses Academic Article
A protocol for developing early warning score models from vital signs data in hospitals using ensembles of decision trees Academic Article
A quantitative analysis of qualitative studies in clinical journals for the 2000 publishing year Academic Article
A randomized trial of Pegaptanib sodium for age-related macular degeneration used an innovative design to explore disease-modifying effects Academic Article
A realist review to understand the efficacy and outcomes of interventions designed to minimise, reverse or prevent the progression of frailty Academic Article
A reporting guideline for clinical platelet transfusion studies from the BEST Collaborative Academic Article
A review of randomized controlled trials comparing the effectiveness of hand held computers with paper methods for data collection Academic Article
A risk of bias instrument for non-randomized studies of exposures: A users’ guide to its application in the context of GRADE Academic Article
A scoping review establishes need for consensus guidance on reporting health equity in observational studies Academic Article
A scoping review of comparisons between abstracts and full reports in primary biomedical research Academic Article
A small p-value from an observed data is not evidence of adequate power for future similar-sized studies: A cautionary note Academic Article
A statistical note on Karl Pearson’s 1904 meta-analysis Academic Article
A suicide prevention strategy for youth presenting to the emergency department with suicide related behaviour: protocol for a randomized controlled trial Academic Article
A systematic overview of adolescent suicide prevention programs. Academic Article
A systematic overview of the effectiveness of home visiting as a delivery strategy for public health nursing interventions. Academic Article
A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications Academic Article
A systematic review of comparisons between protocols or registrations and full reports in primary biomedical research Academic Article
A systematic review of definitions and reporting of bleeding outcome measures in haemophilia Academic Article
A systematic review of psychoeducational intervention trials for the management of chronic stable angina Academic Article
A systematic review of psychometric evaluations of outcome assessments for complex regional pain syndrome Academic Article
A systematic review of quality of reporting in registered intimate partner violence studies: where can we improve? Academic Article
A systematic review of screening questionnaires for obstructive sleep apnea Academic Article
A systematic review of the quality of publications reporting coronary artery bypass grafting trials. Academic Article
A systematic survey of randomised trials that stopped early for reasons of futility Academic Article
A systematic survey of the methods literature on the reporting quality and optimal methods of handling participants with missing outcome data for continuous outcomes in randomized controlled trials Academic Article
A systematic survey on reporting and methods for handling missing participant data for continuous outcomes in randomized controlled trials Academic Article
A systematic survey showed important limitations in the methods for assessing drug safety among systematic reviews Academic Article
A systematic survey shows that reporting and handling of missing outcome data in networks of interventions is poor Academic Article
A tailored online safety and health intervention for women experiencing intimate partner violence: the iCAN Plan 4 Safety randomized controlled trial protocol Academic Article
A taxonomy and critical review of tested strategies for the application of clinical practice recommendations: from "official" to "individual" clinical policy. Academic Article
A taxonomy and framework for identifying and developing actionable statements in guidelines suggests avoiding informal recommendations Academic Article
A three-stage approach to measuring health inequalities and inequities Academic Article
A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial Academic Article
A tutorial on methodological studies: the what, when, how and why Academic Article
A tutorial on pilot studies: the what, why and how Academic Article
A tutorial on sensitivity analyses in clinical trials: the what, why, when and how Academic Article
ACCOUNTING FOR BETWEEN-STUDY VARIATION IN INCREMENTAL NET BENEFIT IN VALUE OF INFORMATION METHODOLOGY Academic Article
AHRQ Series Paper 4: Assessing harms when comparing medical interventions: AHRQ and the Effective Health-Care Program Academic Article
ALeS: adaptive-length spaced-seed design Academic Article
APPLICATION OF THE CONSOLIDATED STANDARDS OF REPORTING TRIALS (CONSORT) IN THE FRACTURE CARE LITERATURE Academic Article
Above all, do no harm: Assessing the risk of an adverse reaction Academic Article
Academic Primer Series: Five Key Papers about Study Designs in Medical Education Academic Article
Academic response to improving value and reducing waste: A comprehensive framework for INcreasing QUality In patient-oriented academic clinical REsearch (INQUIRE) Academic Article
Accounting for center in the Early External Cephalic Version trials: an empirical comparison of statistical methods to adjust for center in a multicenter trial with binary outcomes Academic Article
Accounting for health literacy and intervention preferences when reducing unhealthy snacking: protocol for an online randomised controlled trial Academic Article
Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial: Design and Methods Academic Article
Active patient involvement in the education of health professionals Academic Article
Acupuncture for enhancing early recovery of bowel function in cancer Academic Article
Acupuncture for the alleviation of lateral epicondyle pain: a systematic review Academic Article
Acute Cardiac Functional and Morphological Changes After Anthracycline Infusions in Children Academic Article
Adaptive design methods in dialysis clinical trials: a systematic review protocol Academic Article
Adaptive platform trials: definition, design, conduct and reporting considerations Academic Article
Addressing Challenges When Applying GRADE to Public Health Guidelines: A Scoping Review Protocol and Pilot Analysis Academic Article
Addressing continuous data measured with different instruments for participants excluded from trial analysis: a guide for systematic reviewers Academic Article
Addressing efficiency: Economic evaluation and the agenda for CAM researchers Academic Article
Addressing the Unit of Analysis in Medical Care Studies Academic Article
Addressing the burden of hospital‐related venous thromboembolism: the role of extended anticoagulant prophylaxis Academic Article
Addressing uncertainty in relative effectiveness assessments by HTA organizations Academic Article
Adherence measurement and patient recruitment methods are poor in intervention trials to improve patient adherence Academic Article
Adherence to Standards for Reporting Diagnostic Accuracy in Emergency Medicine Research Academic Article
Adjuvant chemotherapy with CEF versus CMF for node-positive breast cancer. Academic Article
Adolescents with cerebral palsy: stability in measurement of quality of life and health-related quality of life over 1 year Academic Article
Advanced statistics: Understanding Medical Record Review (MRR) Studies Academic Article
Advances in Genomic Analysis of Stroke Academic Article
Advancing Concussion Assessment in Pediatrics (A-CAP): a prospective, concurrent cohort, longitudinal study of mild traumatic brain injury in children: protocol study Academic Article
Advancing implementation frameworks with a mixed methods case study in child behavioral health Academic Article
Advancing the Science in Gastric Pre-Neoplasia: Study Design Considerations Academic Article
Adverse childhood experiences (ACEs) and cardiovascular development from childhood to early adulthood: study protocol of the Niagara Longitudinal Heart Study Academic Article
Affective Instability in Personality Disorders Academic Article
Age trends in direct medical costs of pediatric asthma: A population study Academic Article
Age-Specific Search Strategies for Medline Academic Article
Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time Academic Article
Agreement between study designs: a systematic review comparing observational studies and randomized trials of surgical treatments for necrotizing enterocolitis Academic Article
Agreement in reporting between trial publications and current clinical trial registry in high impact journals: A methodological review Academic Article
Algorithm for predicting death among older adults in the home care setting: study protocol for the Risk Evaluation for Support: Predictions for Elder-life in the Community Tool (RESPECT) Academic Article
All-arthroscopic versus mini-open repair of small or moderate-sized rotator cuff tears: A protocol for a randomized trial [NCT00128076] Academic Article
Allocation techniques for balance at baseline in cluster randomized trials: a methodological review Academic Article
Alternatives to project-specific consent for access to personal information for health research: Canadian public opinion Conference Paper
Alternatives to project-specific consent for access to personal information for health research: Insights from a public dialogue Academic Article
Although not consistently superior, the absolute approach to framing the minimally important difference has advantages over the relative approach Academic Article
An Assessment of Clinically Useful Measures of the Consequences of Treatment Academic Article
An Ep-ICD Based Index Is a Marker of Aggressiveness and Poor Prognosis in Thyroid Carcinoma Academic Article
An Indigenous Lens on Priorities for the Canadian Brain Research Strategy Academic Article
An Introduction to Evidence-Based Practice for Hand Surgeons and Therapists Academic Article
An N of 1 Service: Applying the Scientific Method in Clinical Practice Academic Article
An Official ATS Statement: Grading the Quality of Evidence and Strength of Recommendations in ATS Guidelines and Recommendations Academic Article
An empirical comparison of methods for analyzing correlated data from a discrete choice survey to elicit patient preference for colorectal cancer screening Academic Article
An empirical study using permutation-based resampling in meta-regression Academic Article
An evaluation of the comparative effectiveness of geriatrician-led comprehensive geriatric assessment for improving patient and healthcare system outcomes for older adults: a protocol for a systematic review and network meta-analysis Academic Article
An evaluation of the structural validity of the shoulder pain and disability index (SPADI) using the Rasch model Academic Article
An evidence-based approach to gastroenterology therapy Academic Article
An exploratory cluster randomised controlled trial of knowledge translation strategies to support evidence-informed decision-making in local governments (The KT4LG study) Academic Article
An improved method for analysis of interrupted time series (ITS) data: accounting for patient heterogeneity using weighted analysis Academic Article
An institutional ethnography of chronic pain management in family medicine (COPE) study protocol Academic Article
An integrated exploration into the social and environmental determinants of health: the Saskatchewan Population Health and Evaluation Research Unit (SPHERU). Academic Article
An introduction to multiplicity issues in clinical trials: the what, why, when and how Academic Article
An overview of platform trials with a checklist for clinical readers Academic Article
Analysis and Interpretation of Treatment Effects in Subgroups of Patients in Randomized Clinical Trials Academic Article
Analysis and reporting of stratified cluster randomized trials—a systematic survey Academic Article
Analysis of Observational Studies: A Guide to Understanding Statistical Methods Academic Article
Ankylosing spondylitis antirheumatic drug trials. I. Effects of standardization procedures on observer dependent outcome measures. Academic Article
Ankylosing spondylitis antirheumatic drug trials. II. Tables for calculating sample size for clinical trials. Academic Article
Ankylosing spondylitis antirheumatic drug trials. III. Setting the delta for clinical trials of antirheumatic drugs--results of a consensus development (Delphi) exercise. Academic Article
Anticoagulant therapy for the thrombotic complications of the antiphospholipid antibody syndrome Conference Paper
Anticonvulsants for behavioral and psychological symptoms in dementia: protocol for a systematic review Academic Article
Antioxidants in the prevention of human atherosclerosis. Summary of the proceedings of a National Heart, Lung, and Blood Institute Workshop: September 5-6, 1991, Bethesda, Maryland. Academic Article
Antithrombotic drug development for atrial fibrillation: Proceedings, Washington, DC, July 25-27, 2005 Academic Article
Análisis interino en ensayos clínicos: una guía metodológica Academic Article
Applicability of the AGREE II Instrument in Evaluating the Development Process and Quality of Current National Academy of Clinical Biochemistry Guidelines Academic Article
Application of Epidemiological Methodology to Sports ana Exercise Science Research Academic Article
Application of the STROBE statement to the hypospadias literature: Report of the international pediatric urology task force on hypospadias Academic Article
Applying epidemiological principles to ergonomics: A checklist for incorporating sound design and interpretation of studies Academic Article
Applying evidence-based methods to the development and use of adverse outcome pathways Academic Article
Appraisal of clinical practice guidelines for management of paediatric type 2 diabetes mellitus using the AGREE II instrument: a systematic review protocol Academic Article
Appraising Qualitative Research for Evidence Syntheses: A Compendium of Quality Appraisal Tools Academic Article
Appraising the exercise oncology literature: a reminder of the rigour needed in systematic reviews Academic Article
Approaches of integrating the development of guidelines and quality indicators: a systematic review Academic Article
Archimedes: does caffeine treatment for apnoea of prematurity improve neurodevelopmental outcome in later life? Academic Article
Are We Measuring What Really Counts? Academic Article
Are current standards of reporting quality for clinical trials sufficient in addressing important sources of bias? Academic Article
Are placebo‐controlled trials ethical in areas where current guidelines recommend therapy? No Academic Article
Are postbereavement research interviews distressing to carers? Lessons learned from palliative care research Academic Article
Are systematic reviews and meta-analyses still useful research? Yes Academic Article
Are the Results of the Extracranial–Intracranial Bypass Trial Generalizable? Academic Article
Are the correct outcomes being measured in studies of oral anticoagulants? A systematic survey Academic Article
As a matter of fact: evidence-based decision-making unplugged Academic Article
Aspirin and clonidine in non-cardiac surgery: acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation (POISE) 2 randomised controlled trial Academic Article
Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis Academic Article
Assessing proximal risks for acute traumatic events: the case-crossover design Academic Article
Assessing sensitivity to change: choosing the appropriate change coefficient Academic Article
Assessing the Implementation and Effectiveness of the Electronic Patient-Reported Outcome Tool for Older Adults With Complex Care Needs: Mixed Methods Study Academic Article
Assessing the effectiveness of ‘pulse radiofrequency treatment of dorsal root ganglion’ in patients with chronic lumbar radicular pain: study protocol for a randomized control trial Academic Article
Assessing the quality of reports of randomised trials: implications for the conduct of meta-analyses. Academic Article
Assessment of Evidence Quality in Inflammatory Bowel Disease Guidance: The Use and Misuse of GRADE Academic Article
Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how Academic Article
Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta‐analysis of randomized controlled trials Academic Article
Assessment of effectiveness of major bleeding management: proposed definitions for effective hemostasis: communication from the SSC of the ISTH Academic Article
Assessment of efficacy of varicocele repair for male subfertility: a systematic review Academic Article
Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol Academic Article
Assistive technologies that support social interaction in long-term care homes Academic Article
Assistive technologies that support social interaction in long-term care homes: a scoping review protocol. Academic Article
Association between BDNF levels and suicidal behaviour: a systematic review protocol Academic Article
Association between body mass index and suicidal behaviors: a systematic review protocol Academic Article
Association between cannabis use and treatment outcomes in patients receiving methadone maintenance treatment: a systematic review protocol Academic Article
Association between framing of the research question using the PICOT format and reporting quality of randomized controlled trials Academic Article
Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review Academic Article
Association between progression-free survival and health-related quality of life in oncology: a systematic review protocol Academic Article
Association between statistical significance and time to publication among systematic reviews: a study protocol for a meta-epidemiological investigation Academic Article
Association between vaping and health outcomes in patients with opioid use disorder: a systematic review protocol Academic Article
Assumptions of Expected Benefits in Randomized Phase III Trials Evaluating Systemic Treatments for Cancer Academic Article
Attending to Striatal Ups and Downs in Addictions Academic Article
Attributes of context relevant to healthcare professionals’ use of research evidence in clinical practice: a multi-study analysis Academic Article
Audience responses to a research-based drama about life after breast cancer Academic Article
Author guidelines for conducting systematic reviews and meta-analyses Academic Article
Authors seldom report the most patient-important outcomes and absolute effect measures in systematic review abstracts Academic Article
Authorship and Ethical Considerations in the Conduct of Observational Studies Academic Article
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial Academic Article
Balancing risk and benefit in venous thromboembolism trials: concept for a bivariate endpoint trial design and analytic approach Academic Article
Barrett's Oesophagus Surveillance versus endoscopy at need Study (BOSS): protocol and analysis plan for a multicentre randomized controlled trial Academic Article
Barriers to HIV care among Francophone African, Caribbean and Black immigrant people living with HIV in Canada: a protocol for a scoping systematic review Academic Article
Barriers to participating in an HIV vaccine trial Academic Article
Bayesian methods for pilot studies Academic Article
Be careful about drawing conclusions. Academic Article
Bedtime versus morning use of antihypertensives for cardiovascular risk reduction (BedMed): protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial Academic Article
Before–after paired data Academic Article
Bench-to-bedside research and the human tumor stem-cell assay--bridging the credibility gap. Academic Article
Benchmarking: Applications to Transfusion Medicine Academic Article
Benefit-risk ratios in the assessment of the clinical evidence of a new therapy Academic Article
Best (but oft-forgotten) practices: intention-to-treat, treatment adherence, and missing participant outcome data in the nutrition literature Academic Article
Best (but oft-forgotten) practices: sensitivity analyses in randomized controlled trials Academic Article
Best (but oft-forgotten) practices: the multiple problems of multiplicity—whether and how to correct for many statistical tests Academic Article
Best Practices for BREAST-Q Research: A Systematic Review of Study Methodology Academic Article
Best foot forward: now is the time for Canadian ethical guidance on prospective interventional trials of antemortem interventions in organ donation Academic Article
Beyond the treatment effect: Evaluating the effects of patient preferences in randomised trials Academic Article
Bias in transfusion research: from study design to result reporting Academic Article
Bias-corrected estimator for intraclass correlation coefficient in the balanced one-way random effects model Academic Article
Binary Outcomes Are Not Better than Continuous Variables in Randomized Controlled Trials Academic Article
Biological plausibility in environmental health systematic reviews: a GRADE concept paper Academic Article
Body-mass index, abdominal adiposity, and cardiovascular risk Academic Article
Brazilian medicinal plants to treat upper respiratory tract and bronchial illness: systematic review and meta-analyses--study protocol Academic Article
Bridge or continue Coumadin for device surgery: a randomized controlled trial rationale and design Academic Article
Bringing health services research to (and from) critical care Academic Article
Bringing the Family's Voice to Research Academic Article
Bringing the Life Needs Model to life: implementing a service delivery model for pediatric rehabilitation. Academic Article
Bronchodilator delivery in acute airflow obstruction. A meta-analysis Academic Article
Building Bridges: Describing a Process for Indigenous Engagement in Epidemiology Academic Article
Building clinical trial priorities at the University of Rwanda Academic Article
CIHR Candrive Cohort Comparison with Canadian Household Population Holding Valid Driver’s Licenses Academic Article
CNODES: the Canadian Network for Observational Drug Effect Studies. Academic Article
CONCEPTT: Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial: A multi-center, multi-national, randomized controlled trial - Study protocol Academic Article
CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials Academic Article
CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomised trials Academic Article
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials (Chinese version) Academic Article
CONSORT Harms 2022 statement, explanation, and elaboration: updated guideline for the reporting of harms in randomised trials Academic Article
CONSORT Harms 2022 statement, explanation, and elaboration: updated guideline for the reporting of harms in randomized trials Academic Article
CONSORT and clinical trial reporting: room for improvement Academic Article
CONSORT comes to TRANSFUSION Academic Article
CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement Academic Article
CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement Academic Article
CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration Academic Article
CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration Academic Article
COST AND EFFICIENCY IN THE CHOICE OF MATCHED AND UNMATCHED CASE-CONTROL STUDY DESIGNS1 Academic Article
COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine Academic Article
CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients Academic Article
Can We Learn Anything from Small Trials? Academic Article
Can an antimicrobial stewardship program reduce length of stay of immune-competent adult patients admitted to hospital with diagnosis of community-acquired pneumonia? Study protocol for pragmatic controlled non-randomized clinical study Academic Article
Can observational studies replace or complement experiment? Academic Article
Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Academic Article
Can we differentiate the low-molecular-weight heparins? Academic Article
Can you use a sequential sample of patients as a substitute for a full practice audit?: Study of mammography screening rates in 20 family practices in Ontario. Academic Article
Canadian Alliance for Healthy Hearts and Minds: First Nations Cohort Study Rationale and Design Academic Article
Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT): Rationale and protocol Academic Article
Canadian Phase III Randomized Trial of Stereotactic Body Radiotherapy Versus Conventionally Hypofractionated Radiotherapy for Stage I, Medically Inoperable Non–Small-Cell Lung Cancer – Rationale and Protocol Design for the Ontario Clinical Oncology Group (OCOG)-LUSTRE Trial Academic Article
Canadian study of health and aging: study methods and prevalence of dementia. Academic Article
Candesartan in heart failure—assessment of reduction in mortality and morbidity (CHARM): Rationale and design Academic Article
Capture-mark-recapture to estimate the number of missed articles for systematic reviews in surgery Academic Article
Cardiac donation after circulatory determination of death: protocol for a mixed-methods study of healthcare provider and public perceptions in Canada Academic Article
Cardiac rehabilitation after myocardial infarction. Combined experience of randomized clinical trials Academic Article
Cardiovascular Thrombotic Events in Controlled, Clinical Trials of Rofecoxib Academic Article
Cardiovascular outcome trials in patients with chronic kidney disease: challenges associated with selection of patients and endpoints Academic Article
Care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study Academic Article
Case-control studies for the evaluation of screening Academic Article
Celebrities’ impact on health-related knowledge, attitudes, behaviors, and status outcomes: protocol for a systematic review, meta-analysis, and meta-regression analysis Academic Article
Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience Academic Article
Central statistical monitoring: Detecting fraud in clinical trials Academic Article
Central venous catheter replacement strategies Academic Article
Challenges in Systematic Reviews That Evaluate Drug Efficacy or Effectiveness Academic Article
Challenges in designing antirheumatic drug trials. Academic Article
Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction Academic Article
Challenges to complete and useful data sharing Academic Article
Chapter 5: Assessing Risk of Bias as a Domain of Quality in Medical Test Studies Academic Article
Characteristics and quality of systematic reviews and meta-analyses of observational nutritional epidemiology: a cross-sectional study Academic Article
Chemotherapy for recurrent, metastatic, or persistent cervical cancer: a systematic review Academic Article
Child hunger in Canada. Academic Article
Chronic pain self-management support with pain science education and exercise (COMMENCE): study protocol for a randomized controlled trial Academic Article
Clinical Commentary in Response To: Relationship between Patient Satisfaction and Functional Outcome Metrics 3 Months after Surgical Treatment for Distal Radius Fractures Academic Article
Clinical Comparisons of Inhaler Systems: What are the Important Aspects? Academic Article
Clinical Experience and Quality of Health Care Academic Article
Clinical Presentation of Attention-Deficit/Hyperactivity Disorder in Preschool Children: The Preschoolers with Attention-Deficit/Hyperactivity Treatment Study (PATS) Academic Article
Clinical Research Designs: Quantitative Studies Academic Article
Clinical Research in Aesthetic Surgery Academic Article
Clinical Research in Breast Surgery: Reduction and Postmastectomy Reconstruction Academic Article
Clinical Research in Head and Neck Reconstruction Academic Article
Clinical Research in Pediatric Plastic Surgery and Systematic Review of Quality-of-Life Questionnaires Academic Article
Clinical Research on Acupuncture: Part 1. What Have Reviews of the Efficacy and Safety of Acupuncture Told Us So Far? Academic Article
Clinical Research on Acupuncture: Part 2. Controlled Clinical Trials, an Overview of Their Methods Academic Article
Clinical Research: From Case Reports to International Multicenter Clinical Trials Academic Article
Clinical Trial Data Sharing for COVID-19–Related Research Academic Article
Clinical Trial Design in Acute Lung Injury—Issues and Controversies Academic Article
Clinical Trial Design in Fracture-Healing Research: Meeting the Challenge Academic Article
Clinical Trial Evidence Supporting US Food and Drug Administration Approval of Novel Cancer Therapies Between 2000 and 2016 Academic Article
Clinical Trial Registration in Physical Therapy Journals: Recommendations from the International Society of Physiotherapy Journal Editors Academic Article
Clinical Usefulness of n-of-1 Randomized Controlled Trials in Patients with Nonreversible Chronic Airflow Limitation Academic Article
Clinical and Methodological Factors Related to Reliability of the Best-Estimate Diagnostic Procedure Academic Article
Clinical case reports and case series research in evaluating surgery. Part II. The content and form: uses of single clinical case reports and case series research in surgical specialties. Academic Article
Clinical diagnostic criteria for premenstrual syndrome and guidelines for their quantification for research studies Academic Article
Clinical evaluation of electrohysterography as method of monitoring uterine contractions during labor: A propensity score matched study Academic Article
Clinical experience may affect clinician compliance with assigned treatment in randomized trials Academic Article
Clinical impact versus factor analysis for quality of life questionnaire construction Academic Article
Clinical markers of endometriosis: Have we been too quick to judge? Academic Article
Clinical neurophysiology: Research methods and event-related potential components as assessment tools Chapter
Clinical practice guideline on the use of manipulation or mobilization in the treatment of adults with mechanical neck disorders Academic Article
Clinical research design and reporting: always room for improvement! Academic Article
Clinical trial opportunities in hemostasis and thrombosis: NHBLI State-of-the-science symposium Academic Article
Clinical trial registration in physiotherapy journals: Recommendations from the International Society of Physiotherapy Journal Editors Academic Article
Clinical trials evaluating pathogen-reduced platelet products: methodologic issues and recommendations Academic Article
Clinical trials in COVID-19 management & prevention: A meta-epidemiological study examining methodological quality Academic Article
Clinical trials of disease stages in COVID 19: complicated and often misinterpreted Academic Article
Clinician trialist rounds: 28. When RCT participants are lost to follow-up. Part 1: Why even a few can matter Academic Article
Clinician-trialist rounds: 11. When your grant gets turned down – part 1: remorse, anger, and reconciliation Academic Article
Clinician-trialist rounds: 25. Designing an evidence-based introductory graduate course in clinical trials. Part 2: Applying the evidence to your RCT course design Academic Article
Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol) Academic Article
Clopidogrel and percutaneous coronary intervention Academic Article
Cochrane reviews in perspective: the importance of appropriate conclusions and timing of publication Academic Article
Coenrollment in a Randomized Trial of High-Frequency Oscillation Conference Paper
Coffee and Coronary Heart Disease Academic Article
Cohort Profile: The Canadian Observational Cohort collaboration Academic Article
Cohort studies investigating the effects of exposures: key principles that impact the credibility of the results Academic Article
Collaborative leadership and the implementation of community-based fall prevention initiatives: a multiple case study of public health practice within community groups Academic Article
Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation Academic Article
Colloid Use for Fluid Resuscitation: Evidence and Spin Academic Article
Colloid Use in the Critically Ill Academic Article
Comment on “Perspective: NutriGrade: A Scoring System to Assess and Judge the Meta-Evidence of Randomized Controlled Trials and Cohort Studies in Nutrition Research” Academic Article
Commentary III - Making workplaces healthier: generating better evidence on work organization intervention research Academic Article
Comments on ‘Sequential meta-analysis: an efficient decision-making tool’ by I van der Tweel and C Bollen Academic Article
Common Pitfalls in the Conduct of Clinical Research Academic Article
Common data elements for clinical research in mitochondrial disease: a National Institute for Neurological Disorders and Stroke project Academic Article
Communication Beliefs About Youth and Old Age in Asia and Canada Academic Article
Community service provider perceptions of implementing older adult fall prevention in Ontario, Canada: a qualitative study Academic Article
Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses Academic Article
Comparative effectiveness of the different components of care provided in heart failure clinics—protocol for a systematic review and network meta-analysis Academic Article
Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy Academic Article
Comparing the effectiveness of copper intrauterine devices available in Canada. Is FlexiT non-inferior to NovaT when inserted immediately after first-trimester abortion? Study protocol for a randomized controlled trial Academic Article
Comparing the feasibility, acceptability, clinical-, and cost-effectiveness of mental health e-screening to paper-based screening on the detection of depression, anxiety, and psychosocial risk in pregnant women: a study protocol of a randomized, parallel-group, superiority trial Academic Article
Comparing the use of aggregate data and various methods of integrating individual patient data to network meta-analysis and its application to first-line ART Academic Article
Comparison between the standard and a new alternative format of the Summary-of-Findings tables in Cochrane review users: study protocol for a randomized controlled trial Academic Article
Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation Academic Article
Comparison of Echocardiographic and Cardiac Magnetic Resonance Imaging for Assessing Right Ventricular Function in Adults With Repaired Tetralogy of Fallot Academic Article
Comparison of Preprint Postings of Randomized Clinical Trials on COVID-19 and Corresponding Published Journal Articles Academic Article
Comparison of Standardization Methods for the Harmonization of Phenotype Data: An Application to Cognitive Measures Academic Article
Comparison of health-related quality of life in patients with atrial fibrillation treated with catheter ablation or antiarrhythmic drug therapy: a systematic review and meta-analysis protocol Academic Article
Comparison of physical interventions, behavioral interventions, natural health products, and pharmacologics to manage hot flashes in patients with breast or prostate cancer: protocol for a systematic review incorporating network meta-analyses Academic Article
Comparison of questionnaires determining patient satisfaction with medical care. Academic Article
Comparison of the ability of double-robust estimators to correct bias in propensity score matching analysis. A Monte Carlo simulation study Academic Article
Comparison of ventilatory modes to facilitate liberation from mechanical ventilation: protocol for a systematic review and network meta-analysis Academic Article
Complementary medicine and older people: past research and future directions Academic Article
Complexity science education for clinical nurse researchers Academic Article
Complication Reporting in Orthopaedic Trials Academic Article
Comprehensiveness and bias in reporting clinical trials. Study of reviews of pneumococcal vaccine effectiveness. Academic Article
Computerized administration of health-related quality of life instruments compared to interviewer administration may reduce sample size requirements in clinical research: a pilot randomized controlled trial among rheumatology patients. Academic Article
Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies Academic Article
Concurrent Cisplatin-based Chemotherapy plus Radiotherapy for Cervical Cancer: Academic Article
Concurrent validity of the alcohol purchase task in relation to alcohol involvement: protocol for a systematic review and meta-analysis Academic Article
Conducting EQ-5D Valuation Studies in Resource-Constrained Countries: The Potential Use of Shrinkage Estimators to Reduce Sample Size Academic Article
Conducting economic evaluations alongside multinational clinical trials: Toward a research consensus Academic Article
Conducting industry-partnered trials in orthopaedic surgery Academic Article
Conducting proportional meta-analysis in different types of systematic reviews: a guide for synthesisers of evidence Academic Article
Confidence interval of risk difference by different statistical methods and its impact on the study conclusion in antibiotic non-inferiority trials Academic Article
Confidentiality and prescriptions. Academic Article
Confounding: What is it and how do we deal with it? Academic Article
Confronting the Confounders: The Meaning, Detection, and Treatment of Confounders in Research Academic Article
Consensus statement on the methodology of injury and illness surveillance in FINA (aquatic sports): Table 1 Academic Article
Consent for use of personal information for health research: Do people with potentially stigmatizing health conditions and the general public differ in their opinions? Academic Article
Consent, including advanced consent, of older adults to research in care homes: a qualitative study of stakeholders’ views in South Wales Academic Article
Considerations and guidance in designing equity-relevant clinical trials Academic Article
Considering race/ethnicity and socio-economic status in randomized controlled trials. A commentary on Frampton et al.'s systematic review generalizing trial findings and tackling health disparities in asthma research Academic Article
Consistency of Phase III Clinical Trial Abstracts Presented at an Annual Meeting of the American Society of Clinical Oncology Compared With Their Subsequent Full-Text Publications Conference Paper
Consolidation Therapy With Autologous Bone Marrow Transplantation in Adults With Acute Myeloid Leukemia: A Meta-analysis Academic Article
Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials Academic Article
Constructing trials to show whether urodynamic studies are necessary in lower urinary tract dysfunction Academic Article
Construction of social value or utility-based health indices: The usefulness of factorial experimental design plans Academic Article
Contemporary trends in the level of evidence in general thoracic surgery clinical research Academic Article
Content and methods of studies on the prevention and treatment of mental disorders in selected psychiatric journals. Academic Article
Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project Academic Article
Control of Confounding and Reporting of Results in Causal Inference Studies. Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals Academic Article
Controversy and Debate Series on Core Outcome Sets: The SOLAR (Standardized Outcomes Linking Across StakeholdeRs) system and hub and spokes model for direct core outcome measures in health care and its relation to GRADE Academic Article
Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery Academic Article
Core Outcome Set Development for Adolescent Major Depressive Disorder Clinical Trials: A Registered Report Academic Article
Core Outcomes Set for Trials in People With Coronavirus Disease 2019 Academic Article
Core outcome set for studies on pregnant women with vasa previa (COVasP): a study protocol Academic Article
Coronary stent assessability by 64 slice multi-detector computed tomography Academic Article
Correction for Multiple Testing Academic Article
Correction to the Relative Risk Calculation for Gadolinium-enhanced MR Imaging and Nephrogenic Systemic Fibrosis Academic Article
Correction: Reported Methodologic Quality and Discrepancies between Large and Small Randomized Trials in Meta-Analyses Academic Article
Correlation of single arm versus randomised phase 2 oncology trial characteristics with phase 3 outcome Academic Article
Correspondence Academic Article
Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial Academic Article
Corticosteroid treatment for sepsis Academic Article
Corticosteroids in sepsis: an updated systematic review and meta-analysis (protocol) Academic Article
Cost Implication of an Early Invasive Strategy on Weekdays and Weekends in Patients With Acute Coronary Syndromes Academic Article
Costs and Cost-Effectiveness of Allogeneic Stem Cell Transplantation in Children Are Predictable Academic Article
Counting the cost of proton pump inhibitors Academic Article
Credibility of claims of subgroup effects in randomised controlled trials: systematic review Academic Article
Critical Appraisal of Research Evidence for Its Validity and Usefulness Academic Article
Critical Care Cardiology Research Academic Article
Critical appraisal of rigour in interpretive phenomenological nursing research Academic Article
Critical appraisal of the health research literature: prevalence or incidence of a health problem. Academic Article
Critical reflections on evidence, ethics and effectiveness in the management of tuberculosis: public health and global perspectives. Academic Article
Cross-linkedversusconventional polyethylene for total hip replacement Academic Article
Crossover designs versus parallel studies in infertility research Academic Article
Crossover trials with a cumulative response Academic Article
Current Pain-Control Practices and Research☆☆☆★ Conference Paper
Cyclophosphamide and plasma exchange in multiple sclerosis Academic Article
DELPHI: accurate deep ensemble model for protein interaction sites prediction Academic Article
Dabigatran monitoring made simple? Academic Article
Data based medicine and clinical judgement Academic Article
Data withdrawal in randomized controlled trials: Defining the problem and proposing solutions Academic Article
Dating violence in mid-adolescence Theory, significance, and emerging prevention initiatives Academic Article
Dear Editor Academic Article
Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer: update to study protocol with follow-up extension Academic Article
Declining Enrolment and Other Challenges in IBD Clinical Trials: Causes and Potential Solutions Academic Article
Decolonizing Scoping Review Methodologies for Literature With, for, and by Indigenous Peoples and the African Diaspora: Dialoguing With the Tensions Academic Article
Defining and measuring health equity effects in research on task shifting interventions in high-income countries: a systematic review protocol Academic Article
Defining clinically important perioperative blood loss and transfusion for the Standardised Endpoints for Perioperative Medicine (StEP) collaborative: a protocol for a scoping review Academic Article
Defining publication bias: protocol for a systematic review of highly cited articles and proposal for a new framework Academic Article
Defining the Outcome Measures for Out-of-hospital Trials in Acute Pulmonary Edema Conference Paper
Defining the capabilities and competencies of high-performing family physicians: a mixed methods study Academic Article
Delayed educational reminders for long-term medication adherence in ST-elevation myocardial infarction (DERLA-STEMI): Protocol for a pragmatic, cluster-randomized controlled trial Academic Article
Demystifying trial networks and network meta-analysis Academic Article
Deprescribing anticholinergic and sedative medicines: protocol for a Feasibility Trial (DEFEAT-polypharmacy) in residential aged care facilities Academic Article
Design and Analytic Considerations in Determining the Cost-Effectiveness of Early Intervention in Asthma from a Multinational Clinical Trial Academic Article
Design and Rationale of Health-Related Quality of Life and Patient-Reported Outcomes Assessment in the Frequent Hemodialysis Network Trials Conference Paper
Design and Use of a Quantitative Scale for Measuring Presyncope Academic Article
Design and analysis of factorial clinical trials: The impact of one treatment's effectiveness on the statistical power and required sample size of the other Academic Article
Design and assessment of clinical trials on continuous infusion. Conference Paper
Design and baseline characteristics of participants in the Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide Academic Article
Design and methods of the MAINTAIN study: A randomized controlled clinical trial of micronutrient and antioxidant supplementation in untreated HIV infection Academic Article
Design and rationale for RE-VERSE AD: A phase 3 study of idarucizumab, a specific reversal agent for dabigatran Academic Article
Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial Academic Article
Design and rationale of the Treatment of Acute Coronary Syndromes with Otamixaban trial: A double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non–ST-segment elevation acute coronary syndromes with a planned early invasive strategy Academic Article
Design considerations for randomised trials in orthopaedic fracture surgery Academic Article
Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis Academic Article
Design of the rivaroxaban for heparin-induced thrombocytopenia study Academic Article
Design, Conduct, and Interpretation of Nonrandomized Orthopaedic Studies: A Practical Approach Academic Article
Design, Progress and Challenges of a Double-Blind Trial of Warfarin versus Aspirin for Symptomatic Intracranial Arterial Stenosis Academic Article
Design, analysis and reporting of multi-arm trials and strategies to address multiple testing Conference Paper
Design, analysis, and presentation of crossover trials Academic Article
Designing Medical Informatics Research and Library--Resource Projects to Increase What Is Learned Academic Article
Designing and Analyzing Clinical Trials with Composite Outcomes: Consideration of Possible Treatment Differences between the Individual Outcomes Academic Article
Designing and Reporting Case Series in Plastic Surgery Academic Article
Designing laboratory-based research studies: is it time for a change? Academic Article
Designing research in vulnerable populations: lessons from HIV prevention trials that stopped early Academic Article
Detecting, quantifying and adjusting for publication bias in meta-analyses: protocol of a systematic review on methods Academic Article
Determinants of Walking Exercise Among Individuals With Intermittent Claudication Academic Article
Determinants of physical activity in older adults: an umbrella review protocol Academic Article
Determining Optimal Therapy — Randomized Trials in Individual Patients Academic Article
Determining Optimal Therapy — Randomized Trials in Individual Patients Academic Article
Determining causation—A case study: Adrenocorticosteroids and osteoporosis Academic Article
Determining optimal sample sizes for multi-stage randomized clinical trials using value of information methods Academic Article
Determining optimal sample sizes for multistage adaptive randomized clinical trials from an industry perspective using value of information methods Academic Article
Determining the Level of Statistician Participation on Canadian-Based Research Ethics Boards Academic Article
Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial Academic Article
Determining the reporting quality of RCTs in clinical pharmacology Academic Article
Determining the reporting quality of RCTs in clinical pharmacology. Academic Article
Developing Optimal Search Strategies for Detecting Clinically Sound Studies in MEDLINE Academic Article
Developing and Implementing a Triangulation Protocol for Qualitative Health Research Academic Article
Developing optimal search strategies for detecting clinically sound and relevant causation studies in EMBASE Academic Article
Development and Validation of a Set of Palliative Medicine Entrustable Professional Activities: Findings from a Mixed Methods Study Academic Article
Development and application of an outcome-centric approach for conducting overviews of reviews Academic Article
Development and design validation of a novel network meta-analysis presentation tool for multiple outcomes: a qualitative descriptive study Academic Article
Development and feasibility testing of decision support for patients who are candidates for a prophylactic implantable defibrillator: a study protocol for a pilot randomized controlled trial Academic Article
Development and validation of a Surgical Prioritization and Ranking Tool and Navigation Aid for Head and Neck Cancer (SPARTAN‐HN) in a scarce resource setting: Response to the COVID‐19 pandemic Academic Article
Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations Academic Article
Development and validation of study filters for identifying controlled non‐randomized studies in PubMed and Ovid MEDLINE Academic Article
Development of Disease-Specific Health-Related Quality-of-Life Instruments for Children With Immune Thrombocytopenic Purpura and Their Parents Academic Article
Development of a Core Outcome Set for Studies on Cardiac Disease in Pregnancy (COSCarP): a study protocol Academic Article
Development of a Core Outcome Set for Studies on Obesity in Pregnant Patients (COSSOPP): a study protocol Academic Article
Development of a Policy-Relevant Child Maltreatment Research Strategy Academic Article
Development of a core measurement set for research in degenerative cervical myelopathy: a study protocol (AO Spine RECODE-DCM CMS) Academic Article
Development of a core outcome set for multimorbidity trials in low/middle-income countries (COSMOS): study protocol Academic Article
Development of a core outcome set for studies on prevention and management of pregnancy-associated venous thromboembolism (COSPVenTE): a study protocol Academic Article
Development of a measure of family-centred care for resource-poor South African settings: the experience of using a modified version of the MPOC-20 Academic Article
Development of a point of care system for automated coma prognosis: a prospective cohort study protocol Academic Article
Development of an instrument to assess individual student performance in small group tutorials. Academic Article
Development of the Assistance to Participate Scale (APS) for children's play and leisure activities Academic Article
Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses Academic Article
Diagnostic Efficacy of Impedance Plethysmography for Clinically Suspected Deep-Vein Thrombosis Academic Article
Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study Academic Article
Dietary Calcium and Blood Pressure Academic Article
Different meta-analysis methods can change judgements about imprecision of effect estimates: a meta-epidemiological study Academic Article
Differential Student Attrition and Differential Exposure Mask Effects of Problem-Based Learning in Curriculum Comparison Studies Academic Article
Differentiating arrhythmogenic right ventricular cardiomyopathy from right ventricular outflow tract ventricular tachycardia using multilead QRS duration and axis Academic Article
Digitalis for treatment of congestive heart failure in patients in sinus rhythm: a systematic review and meta-analysis Academic Article
Dinoprostone vaginal insert for cervical ripening and labor induction: a meta-analysis Academic Article
Discharge Criteria From Perioperative Physical Therapy Academic Article
Discourse on culture in research on immigrant and migrant workers’ health Academic Article
Discrepancies among megatrials Academic Article
Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results: achieving clarity through mixed methods triangulation Academic Article
Discrepancies in published data Academic Article
Diurnal variation of testosterone and estradiol: a source of bias in comparative studies on breast cancer Academic Article
Diversity of Authors of Publications From the Canadian Critical Care Trials Group* Academic Article
Do Authors Report Surgical Expertise in Open Spine Surgery Related Randomized Controlled Trials? A Systematic Review on Quality of Reporting Academic Article
Do You See What I Mean? Indices of Central Tendency Academic Article
Do hip protectors decrease the risk of hip fracture in institutional and community-dwelling elderly? A systematic review and meta-analysis of randomized controlled trials Academic Article
Doctors' perceptions of the effects of interventions tested in prospective, randomised, controlled, clinical trials: results of a survey of ICU physicians Academic Article
Doctor–patient interaction for irritable bowel syndrome in primary care Academic Article
Does Study Design Affect Redislocation Rates After Primary Shoulder Dislocations? A Systematic Review Comparing Prospective and Retrospective Studies Academic Article
Does a "Level I Evidence" rating imply high quality of reporting in orthopaedic randomised controlled trials? Academic Article
Does benefit justify research with children? Academic Article
Does clinical equipoise apply to cluster randomized trials in health research? Academic Article
Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? Academic Article
Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes Academic Article
Double blind, you are the weakest link - goodbye! Academic Article
Driving performance assessments for benzodiazepine receptor agonist–related impairment: a scoping review protocol Academic Article
Drugs and the DST: need for a reappraisal Academic Article
Dynamic systems methods for models of developmental psychopathology Academic Article
Early standardization of high sensitivity troponin T reporting - a lost opportunity Academic Article
Economic Evaluations Conducted for Assessment of Genetic Testing Technologies: A Systematic Review Academic Article
Economic analysis and clinical trials Academic Article
Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol Academic Article
Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial Academic Article
Economic evaluations conducted by Canadian health technology assessment agencies: Where do we stand? Academic Article
Economic evaluations in the critical care literature Academic Article
Editorial ? Beyond PBL Academic Article
Editorial Comment Academic Article
Editorial: Two cheers for clinical practice guidelines: the hopes and headaches of quality improvement in reproductive healthcare Academic Article
Edoxaban for treatment of venous thromboembolism in patients with cancer Academic Article
Effect of Atenolol on Mortality and Cardiovascular Morbidity after Noncardiac Surgery Academic Article
Effect of Fructose on Body Weight in Controlled Feeding Trials Academic Article
Effect of Metformin vs Placebo on and Metabolic Factors in NCIC CTG MA.32 Academic Article
Effect of Smoking Cessation on Mortality After Myocardial Infarction Academic Article
Effect of an interactive text-messaging service on patient retention during the first year of HIV care in Kenya (WelTel Retain): an open-label, randomised parallel-group study Academic Article
Effect of influenza vaccines against mismatched strains: a systematic review protocol Academic Article
Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomised trials Academic Article
Effect of serotonin modulating pharmacotherapies on body mass index and dysglycaemia among children and adolescents: a systematic review and network meta-analysis protocol Academic Article
Effective Ventilation Strategies for Acute Respiratory Distress Syndrome Academic Article
Effectiveness of Percutaneous Coronary Intervention in Patients With Silent Myocardial Ischemia (Post Hoc Analysis of the COURAGE Trial) Academic Article
Effectiveness of Postpartum Support Academic Article
Effectiveness of compression stockings to prevent the post-thrombotic syndrome (The SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trial Academic Article
Effectiveness of guideline dissemination and implementation strategies on health care professionals’ behaviour and patient outcomes in the cancer care context: a systematic review protocol Academic Article
Effectiveness of implementation strategies in improving physician adherence to guideline recommendations in heart failure: a systematic review protocol Academic Article
Effectiveness of instruction in critical appraisal (evidence-based medicine) skills: a critical appraisal. Academic Article
Effectiveness of knowledge translation tools addressing multiple high-burden chronic diseases affecting older adults: protocol for a systematic review alongside a realist review Academic Article
Effectiveness of seasonal influenza vaccination in community-dwelling elderly people: an individual participant data meta-analysis of test-negative design case-control studies Academic Article
Effects of Atrazine in Fish, Amphibians, and Reptiles: An Analysis Based on Quantitative Weight of Evidence Academic Article
Effects of Intravenously Administered Recombinant Vesicular Stomatitis Virus (VSV ΔM51 ) on Multifocal and Invasive Gliomas Academic Article
Effects of Mode and Order of Administration on Generic Health-Related Quality of Life Scores Academic Article
Effects of an evidence service on health-system policy makers' use of research evidence: A protocol for a randomised controlled trial Academic Article
Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol Academic Article
Effects of electroconvulsive therapy on cognitive functioning in patients with depression: protocol for a systematic review and meta-analysis Academic Article
Effects of health literacy, screening, and participant choice on action plans for reducing unhealthy snacking in Australia: A randomised controlled trial Academic Article
Effects of roflumilast in COPD patients receiving inhaled corticosteroid/long-acting β<sub>2</sub>-agonist fixed-dose combination: RE<sup>2</sup>SPOND rationale and study design Academic Article
Effects of study design and trends for EVAR versus OSR Academic Article
Efficacy and Safety of Melatonin as an Anxiolytic and Analgesic in the Perioperative Period Academic Article
Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials Academic Article
Efficacy of Chinese herbal injections combined with fluoropyrimidine and oxaliplatin-based chemotherapy for advanced colorectal cancer Academic Article
Efficacy of temporary work modifications on disability related to musculoskeletal pain or depressive symptoms--study protocol for a controlled trial Academic Article
Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol Academic Article
El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos Academic Article
Emerging Designs in Orthopaedics: Expertise-Based Randomized Controlled Trials Academic Article
Emerging Trends in Clinical Trial Design Academic Article
Empirical Testing of the External Validity of a Discrete Choice Experiment to Determine Preferred Treatment Option: The Case of Sleep Apnea Academic Article
Empirical comparison of methods for analyzing multiple time-to-event outcomes in a non-inferiority trial: a breast cancer study Academic Article
Empirical evidence of bias in infertility research: overestimation of treatment effect in crossover trials using pregnancy as the outcome measure Academic Article
Empirically evaluating the impact of adjudicative tribunals in the health sector: context, challenges and opportunities Academic Article
End-of-Life Care for Seniors: Contributions from a New Emerging Team Academic Article
Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis Academic Article
Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective Academic Article
Endovascular repair of ruptured abdominal aortic aneurysms: A systematic review and meta-analysis Academic Article
Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel Academic Article
Engaging First Nation and Inuit communities in asthma management and control: Assessing cultural appropriateness of educational resources Academic Article
Engaging pregnant individuals and healthcare professionals in an international mixed methods study to develop a core outcome set for studies on placenta accreta spectrum disorder (COPAS): a study protocol Academic Article
Enhancing primary reports of randomized controlled trials: Three most common challenges and suggested solutions Academic Article
Environmental Profile of a Community’s Health (EPOCH): An Ecometric Assessment of Measures of the Community Environment Based on Individual Perception Academic Article
Epistemologic Inquiries in Evidence-Based Medicine Academic Article
Equity considerations in utility-based measures of health outcomes in economic appraisals: An adjustment algorithm Academic Article
Erotic gender differentiation in pedophilia Academic Article
Error-related electrocortical responses in 10-year-old children and young adults Academic Article
Errors in kinematic parameters of a planar joint: Guidelines for optimal experimental design Academic Article
Errors in the implementation, analysis, and reporting of randomization within obesity and nutrition research: a guide to their avoidance Academic Article
Establishing a protocol for building a pan-Canadian population-based monitoring system for early childhood development for children with health disorders: Canadian Children’s Health in Context Study (CCHICS) Academic Article
Establishing thresholds for important benefits considering the harms of screening interventions Academic Article
Estimates of general practitioner workload: a review. Academic Article
Estimating direct healthcare costs attributable to laboratory‐confirmed Lyme disease in Ontario, Canada: A population‐based matched cohort study using health administrative data Academic Article
Estimating the Power of Indirect Comparisons: A Simulation Study Academic Article
Estimating the current and future cancer burden in Canada: methodological framework of the Canadian population attributable risk of cancer (ComPARe) study Academic Article
Estimation of standard deviations and inverse‐variance weights from an observed range Academic Article
Ethical and policy issues in cluster randomized trials: rationale and design of a mixed methods research study Academic Article
Ethical considerations in conducting surgical research in severe complicated intra-abdominal sepsis Academic Article
Ethical review of interpretive research: problems and solutions. Academic Article
Evaluating Agreement: Conducting a Reliability Study Academic Article
Evaluating Implants in Orthopaedic Trials: Tips for Conducting Research Academic Article
Evaluating a community-based exercise intervention with adults living with HIV: protocol for an interrupted time series study Academic Article
Evaluating health related quality of life: An indifference curve interpretation for the time trade-off technique Academic Article
Evaluating injury prevention interventions Academic Article
Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial Academic Article
Evaluating the credibility of anchor based estimates of minimal important differences for patient reported outcomes: instrument development and reliability study Academic Article
Evaluating the design and reporting of pragmatic trials in osteoarthritis research Academic Article
Evaluating the effectiveness, impact and safety of live attenuated and seasonal inactivated influenza vaccination: protocol for the Seasonal Influenza Vaccination Effectiveness II (SIVE II) study Academic Article
Evaluating the endometabolic and bone health effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukaemia: a systematic review protocol Academic Article
Evaluation and Use of Epidemiological Evidence for Environmental Health Risk Assessment: WHO Guideline Document Academic Article
Evaluation of Planned Subgroup Analysis in Protocols of Randomized Clinical Trials Academic Article
Evaluation of WOMAC 20, 50, 70 response criteria in patients treated with hylan G-F 20 for knee osteoarthritis Academic Article
Evaluation of a physiatrist-directed prehabilitation intervention in frail patients with colorectal cancer: a randomised pilot study protocol Academic Article
Evaluation of a research mentorship program in community care Academic Article
Evaluation of clinical practice guidelines. Academic Article
Evaluation of innovations in nursing practice: report and discussion Academic Article
Evaluation of intervention reporting in published emergency medicine clinical trials Academic Article
Evaluation of multisystemic therapy pilot services in Services for Teens Engaging in Problem Sexual Behaviour (STEPS-B): study protocol for a randomized controlled trial Academic Article
Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methods Academic Article
Evaluation of parent and youth experiences in advisory groups as part of a mental healthcare clinical trial: protocol for a mixed-method study Academic Article
Evaluation of the Effectiveness of Suicide Prevention Programs: A Methodological Perspective Academic Article
Evaluation of the quality of clinical data collection for a pan-Canadian cohort of children affected by inherited metabolic diseases: lessons learned from the Canadian Inherited Metabolic Diseases Research Network Academic Article
Evaluation of the use of GRADE in dentistry systematic reviews and its impact on conclusions: a protocol for a methodological study Academic Article
Evaluation research in public health: barriers to the production and dissemination of outcomes data. Academic Article
Event Adjudication Is Unnecessary in Blinded Trials and May Be Detrimental Academic Article
Event-related potential sensitivity to acoustic and semantic properties of terminal words in sentences Academic Article
Evidence and its uses in health care and research: The role of critical thinking Academic Article
Evidence base of clinical diagnosis: The architecture of diagnostic research Academic Article
Evidence-Based Guidelines—An Introduction Academic Article
Evidence-Based Laboratory Medicine: Addressing Bias, Generalisability and Applicability in Studies on Diagnostic Accuracy. The STARD Initiative Academic Article
Evidence-Based Medicine Academic Article
Evidence-Based Priority Setting for Health Care and Research: Tools to Support Policy in Maternal, Neonatal, and Child Health in Africa Academic Article
Evidence-based decision-making in infectious diseases epidemiology, prevention and control: matching research questions to study designs and quality appraisal tools Academic Article
Evidence-based medicine. Academic Article
Evidence-based practice guidelines for instructing individuals with neurogenic memory impairments: What have we learned in the past 20 years? Academic Article
Evidence-based practice: what it is, why we need it. Academic Article
Evidence‐Based Nursing: Rationale and Resources Academic Article
Examining consensus for a standardised patient assessment in community paramedicine home visits: a RAND/UCLA-modified Delphi Study Academic Article
Examining the evidence in anesthesia literature: a survey and evaluation of obstetrical postdural puncture headache reports Academic Article
Examining the social determinants of children's developmental health: protocol for building a pan-Canadian population-based monitoring system for early childhood development Academic Article
Exclusion of studies with no events in both arms in meta-analysis impacted the conclusions Academic Article
Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children Academic Article
Executive functioning: A scoping review of the occupational therapy literature / Les fonctions exécutives : une analyse de la portée de la littérature en ergothérapie Academic Article
Exercise research issues in the spinal cord injured population. Academic Article
Expected value of information and decision making in HTA Academic Article
Expertise-based design in surgical trials: a narrative review Academic Article
Exploring design-related bias in clinical studies on receptor genetic polymorphism of hypertension Academic Article
Exploring some intersections between pharmacokinetics, factor VIII measurement and human morphometrics - impact of recent advances in haemophilia study design on our understanding of optimal haemophilia treatment Academic Article
Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol Academic Article
Exploring the experiences of substitute decision-makers with an exception to consent in a paediatric resuscitation randomised controlled trial: study protocol for a qualitative research study Academic Article
Exploring the uptake and framing of research evidence on universal screening for intimate partner violence against women: a knowledge translation case study Academic Article
Extending the RIGHT statement for reporting adapted practice guidelines in healthcare: the RIGHT-Ad@pt Checklist protocol Academic Article
Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome—More Research Is Needed Academic Article
FENOTEROL AND FATAL ASTHMA Academic Article
Facilitating the Use of Evidence in Practice: Evaluating and Adapting Clinical Practice Guidelines for Local Use by Health Care Organizations Academic Article
Facilitators, barriers and strategies for health-system guidance implementation: a critical interpretive synthesis protocol Academic Article
Factor structure and convergent validity of the Derriford Appearance Scale-24 using standard scoring versus treating ‘not applicable’ responses as missing data: a Scleroderma Patient-centered Intervention Network (SPIN) cohort study Academic Article
Factorial experimental designs Academic Article
Factors affecting exhaled nitric oxide measurements: the effect of sex Academic Article
Factors associated with citation rates in the orthopedic literature. Academic Article
Factors associated with development of gastrointestinal problems in patients with scleroderma: a protocol for a systematic review Academic Article
Factors associated with development of gastrointestinal problems in patients with scleroderma: a systematic review Academic Article
Feasibility and implementation of a healthy lifestyles program in a community setting in Ontario, Canada: protocol for a pragmatic mixed methods pilot study Academic Article
Feasibility of a Systematic, Comprehensive, One-to-One Training (SCOOT) program for new scooter users: study protocol for a randomized control trial Academic Article
Feasibility of a randomized controlled trial to evaluate the impact of decision boxes on shared decision-making processes Academic Article
Feasibility of the Enhancing Participation In the Community by improving Wheelchair Skills (EPIC Wheels) program: study protocol for a randomized controlled trial Academic Article
Financial and family burden associated with cancer treatment in Ontario, Canada Academic Article
Finding Common Ground in Team-Based Qualitative Research Using the Convergent Interviewing Method Academic Article
Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures Academic Article
Fluid Lavage of Open Wounds (FLOW): design and rationale for a large, multicenter collaborative 2 × 3 factorial trial of irrigating pressures and solutions in patients with open fractures Academic Article
Fluid lavage in patients with open fracture wounds (FLOW): an international survey of 984 surgeons Academic Article
Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial Academic Article
Focus group interviews examining attitudes to randomised trials among breast cancer patients and the general community Academic Article
Fondaparinux and prevention of venous thromboembolism after orthopaedic surgery Academic Article
Fondaparinux and prevention of venous thromboembolism after orthopaedic surgery. Academic Article
Fondaparinux in the management of patients with ST-elevation acute myocardial infarction Academic Article
Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT) – Bridging the River Coumarin Academic Article
Forecasting models for human resources in health care Academic Article
Formatting modifications in GRADE evidence profiles improved guideline panelists comprehension and accessibility to information. A randomized trial Academic Article
Forming the Research Question Academic Article
Fracture Risk in Kidney Transplant Recipients Academic Article
Fragility of Results in Ophthalmology Randomized Controlled Trials Academic Article
Framing of research question using the PICOT format in randomised controlled trials of venous ulcer disease: a protocol for a systematic survey of the literature Academic Article
Fraud versus carelessness Academic Article
Frequent Hemodialysis Network (FHN) randomized trials: Study design Academic Article
From diversity comes understanding: health promotion capacity-building and dissemination research in Canada. Academic Article
From sea to shining sea: making collaborative rural research work Academic Article
Functional Dyspepsia Treatment Trial (FDTT): A double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics Academic Article
Functional aging in health and heart failure: the COmPLETE Study Academic Article
Functioning and disability in recent research from Cameroon: a narrative synthesis Academic Article
Funding Oncology Clinical Trials: Are Cooperative Group Trials Sustainable? Academic Article
Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial Academic Article
Further studies are needed to assess the competing therapies for neck pain Academic Article
Future of Evidence Ecosystem Series: Evidence synthesis 2.0: when systematic, scoping, rapid, living, and overviews of reviews come together Academic Article
GENERATING HEALTH TECHNOLOGY ASSESSMENT EVIDENCE FOR RARE DISEASES Academic Article
GRADE Equity Guidelines 2: Considering health equity in GRADE guideline development: Equity extension of the Guideline Development Checklist Academic Article
GRADE Guidance: 31. Assessing the certainty across a body of evidence for comparative test accuracy Academic Article
GRADE Guidelines: 29. Rating the certainty in time-to-event outcomes—Study limitations due to censoring of participants with missing data in intervention studies Academic Article
GRADE Leitlinien: 13. Erstellen von Summary-of-Findings-Tabellen und Evidenzprofilen – kontinuierliche Endpunkte Academic Article
GRADE Leitlinien: 5. Einschätzung der Qualität der Evidenz – Publikationsbias Academic Article
GRADE Leitlinien: 6. Einschätzung der Qualität der Evidenz – Unzureichende Präzision Academic Article
GRADE equity guidelines 1: considering health equity in GRADE guideline development: introduction and rationale Academic Article
GRADE equity guidelines 3: considering health equity in GRADE guideline development: rating the certainty of synthesized evidence Academic Article
GRADE equity guidelines 4: considering health equity in GRADE guideline development: evidence to decision process Academic Article
GRADE guidance 24 optimizing the integration of randomized and non-randomized studies of interventions in evidence syntheses and health guidelines Academic Article
GRADE guidelines 17: assessing the risk of bias associated with missing participant outcome data in a body of evidence Academic Article
GRADE guidelines: 12. Preparing Summary of Findings tables—binary outcomes Academic Article
GRADE guidelines: 15. Going from evidence to recommendation—determinants of a recommendation's direction and strength Academic Article
GRADE guidelines: 21 part 1. Study design, risk of bias, and indirectness in rating the certainty across a body of evidence for test accuracy Academic Article
GRADE guidelines: 21 part 2. Test accuracy: inconsistency, imprecision, publication bias, and other domains for rating the certainty of evidence and presenting it in evidence profiles and summary of findings tables Academic Article
GRADE guidelines: 7. Rating the quality of evidence—inconsistency Academic Article
GRADE-Leitlinien: 11. Gesamtbeurteilung des Vertrauens in Effektschätzer für einen einzelnen Studienendpunkt und für alle Endpunkte Academic Article
GRADE-Leitlinien: 12. Erstellen von „Summary-of-Findings“-Tabellen – Dichotome Endpunkte Academic Article
GRADE-Leitlinien: 9. Heraufstufen der Qualität der Evidenz Academic Article
Gabapentinoids for chronic low back pain: a protocol for systematic review and meta-analysis of randomised controlled trials Academic Article
Gastrointestinal recovery after surgery: protocol for a systematic review Academic Article
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders Academic Article
General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial Academic Article
Generalizability theory for the perplexed: A practical introduction and guide: AMEE Guide No. 68 Academic Article
Generalization and the qualitative–quantitative debate Academic Article
Generating evidence on a risk-based monitoring approach in the academic setting – lessons learned Academic Article
Genetic Polymorphisms and Head and Neck Cancer Outcomes: A Review Academic Article
Genome-Scale Phylogeny and the Detection of Systematic Biases Academic Article
Geographies of Risk in Studies Linking Chronic Air Pollution Exposure to Health Outcomes Academic Article
Getting granted Academic Article
Global Anticoagulant Registry in the Field – Venous Thromboembolism (GARFIELD-VTE) Academic Article
Good or best practice statements: proposal for the operationalisation and implementation of GRADE guidance Academic Article
Grades of Recommendation for Antithrombotic Agents Academic Article
Grading quality of evidence and strength of recommendations for diagnostic tests and strategies Academic Article
Grading the evidence: Levels of evidence and grades of recommendation Academic Article
Graphical Representation of Overlap for OVErviews: GROOVE tool Academic Article
Gross motor performance measure for children with cerebral palsy: study design and preliminary findings. Academic Article
Group Intervention Studies in the Cognitive Rehabilitation of Individuals with Traumatic Brain Injury: Challenges Faced by Researchers Academic Article
Guidance for the Evaluation of Tuberculosis Diagnostics That Meet the World Health Organization (WHO) Target Product Profiles: An Introduction to WHO Process and Study Design Principles Academic Article
Guidance relevant to the reporting of health equity in observational research: a scoping review protocol Academic Article
Guideline Assessment Project II: statistical calibration informed the development of an AGREE II extension for surgical guidelines Academic Article
Guideline conflict of interest management and methodology heavily impacts on the strength of recommendations: comparison between two iterations of the American College of Chest Physicians Antithrombotic Guidelines Academic Article
Guideline conflict of interest management and methodology heavily impacts on the strength of recommendations: comparison between two iterations of the American College of Chest Physicians Antithrombotic Guidelines. Academic Article
Guideline-based quality assurance: a conceptual framework for the definition of key elements Academic Article
Guidelines for Health Technology Assessment Academic Article
Guidelines for Reporting Outcomes in Trial Protocols Academic Article
Guidelines for Reporting Outcomes in Trial Reports Academic Article
Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed Academic Article
Guidelines for reading literature reviews. Academic Article
Guidelines for the clinical and economic evaluation of health care technologies Academic Article
Guidelines that use the GRADE approach often fail to provide complete economic information for recommendations: A systematic survey Academic Article
HIV prevention and treatment interventions for black men who have sex with men in Canada: a protocol for a scoping systematic review Academic Article
HIV prevention in favour of the choice-disabled in southern Africa: study protocol for a randomised controlled trial Academic Article
HOW TO REALIZE A GOOD EPIDEMIOLOGICAL-STUDY .1. HOW TO PREPARE A STUDY Academic Article
HYEs: Do We Need Them and Can They Fulfil the Promise? Academic Article
Handling of Missing Data Academic Article
Handling trial participants with missing outcome data when conducting a meta-analysis: a systematic survey of proposed approaches Academic Article
Health Status Measures: Strategies and Analytic Methods for Assessing Change Scores Academic Article
Health TAPESTRY Ontario: protocol for a randomized controlled trial to test reproducibility and implementation Academic Article
Health related quality of life among children with cancer in Hyderabad, India Academic Article
Health-Related Quality of Life and Cost-Effectiveness Components of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial: Rationale and Design Academic Article
Helicobacter pylori test and treat strategy for young dyspeptic patients: new data Conference Paper
Hi! How are you? Response shift, implicit theories and differing epistemologies. Academic Article
Hierarchy of Evidence: From Case Reports to Randomized Controlled Trials Academic Article
Hierarchy of Evidence: Where Observational Studies Fit in and Why We Need Them Academic Article
High Oxygen Delivery to Preserve Exercise Capacity in Patients with Idiopathic Pulmonary Fibrosis Treated with Nintedanib. Methodology of the HOPE-IPF Study Academic Article
High levels of uPA and PAI-1 predict a good response to anthracyclines Academic Article
Hip Fracture and Proton Pump Inhibitor Therapy: Position Statement Academic Article
Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): protocol for a multicentre randomised trial Academic Article
Hiring, training, and supporting Peer Research Associates: Operationalizing community-based research principles within epidemiological studies by, with, and for women living with HIV Academic Article
Hormone replacement therapy: a time for pause. Academic Article
Hospital Selection for Unit Cost Estimates in Multicentre Economic Evaluations Academic Article
Hostility and Recidivism in Sexual Offenders Academic Article
How Many Patients? How Many Limbs? Analysis of Patients or Limbs in the Orthopaedic Literature: A Systematic Review Academic Article
How Should Results from Completed Studies Influence Ongoing Clinical Trials? Academic Article
How Strong Is the Evidence? Academic Article
How can diagnostic assessment programs be implemented to enhance inter-professional collaborative care for cancer? Academic Article
How do financial (dis)incentives influence health behaviour and costs? Protocol for a systematic literature review of randomised controlled trials Academic Article
How have predictors, moderators, mediators, treatment response, remission and resistance been defined and measured in randomised controlled trials for adolescent depression? A scoping review protocol Academic Article
How many, powerfully? Academic Article
How much science is there in injury prevention and control? Academic Article
How qualitative research can contribute to research in the intensive care unit Academic Article
How representative are student convenience samples? A study of literacy and numeracy skills in 32 countries Conference Paper
How to Appraise the Effectiveness of Treatment Academic Article
How to Design a Good Case Series Academic Article
How to Design a Qualitative Health Research Study. Part 1: Design and Purposeful Sampling Considerations. Academic Article
How to Design a Qualitative Health Research Study. Part 2: Data Generation and Analysis Considerations. Academic Article
How to Keep Up with the Medical Literature: I. Why Try to Keep Up and How to Get Started Academic Article
How to Report and Interpret Screening Test Properties: Guidelines for Driving Researchers Academic Article
How to Use a Randomized Clinical Trial Addressing a Surgical Procedure Academic Article
How to Use a Subgroup Analysis Academic Article
How to Use an Article About Quality Improvement Academic Article
How to Use an Article Reporting a Multiple Treatment Comparison Meta-analysis Academic Article
How to assess a survey in surgery Academic Article
How to conduct a high-quality original study on a diagnostic research topic Academic Article
How to conduct a high-quality original study on a prognostic research topic Academic Article
How to conduct a high-quality systematic review on diagnostic research topics Academic Article
How to critique qualitative research articles. Academic Article
How to generalize efficacy results of randomized trials: recommendations based on a systematic review of possible approaches Academic Article
How to increase the value of randomised trials in COPD research Academic Article
How to optimize participant retention and complete follow-up in surgical research Academic Article
How to use an article on therapy or prevention Academic Article
How to use diagnostic test articles in the intensive care unit Academic Article
How to use noninvasive positive airway pressure device data reports to guide clinical care Academic Article
How to work with a subgroup analysis. Academic Article
How well are journal and clinical article characteristics associated with the journal impact factor? a retrospective cohort study Academic Article
Human Laboratory Paradigms in Alcohol Research Academic Article
Human Papillomavirus Triage of Atypical Squamous Cells of Undetermined Significance: Cost-Effective, But At What Cost? Academic Article
Hyperplastic effects of aerosolized sodium metabisulfite on rat airway mucus-secretory epithelial cells Academic Article
Hypothermia Pediatric Head Injury Trial: The Value of a Pretrial Clinical Evaluation Phase Academic Article
Hypothesis Testing in Superiority, Noninferiority, and Equivalence Clinical Trials Academic Article
INSPIRE (INvestigating Social and PractIcal suppoRts at the End of life): Pilot randomised trial of a community social and practical support intervention for adults with life-limiting illness Academic Article
ISOQOL recommends minimum standards for patient-reported outcome measures used in patient-centered outcomes and comparative effectiveness research Academic Article
Identify and classify interprofessional primary care performance indicators: a scoping review protocol Academic Article
Identifying and understanding the health and social care needs of older adults with multiple chronic conditions and their caregivers: a protocol for a scoping review Academic Article
Identifying candidate quality indicators of tools that support the practice of knowledge translation: a scoping review protocol Academic Article
Identifying genetic and environmental risk factors for chronic orofacial pain syndromes: human models. Academic Article
Identifying non-traditional electronic datasets for population-level surveillance and prevention of cardiometabolic diseases: a scoping review protocol Academic Article
Identifying the domains of context important to implementation science: a study protocol Academic Article
Iloprost Academic Article
Immediate vs. delayed insertion of intrauterine contraception after second trimester abortion: study protocol for a randomized controlled trial Academic Article
Impact of COVID-19 and other pandemics and epidemics on people with pre-existing mental disorders: a systematic review protocol and suggestions for clinical care Academic Article
Impact of Sex on Cardiovascular Outcome in Patients at High Cardiovascular Risk Academic Article
Impact of a Genetic Risk Score on Myocardial Infarction Risk Across Different Ethnic Populations Academic Article
Impact of a new course on students' potential behaviour on encountering ethical dilemmas Academic Article
Impact of cause of death adjudication on the results of the European prostate cancer screening trial Academic Article
Impact of emergency department probiotic treatment of pediatric gastroenteritis: study protocol for the PROGUT (Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment) randomized controlled trial Academic Article
Impact of point-of-care diagnostics on maternal outcomes in HIV-infected women: systematic review and meta-analysis protocol Academic Article
Impact of remuneration, extrinsic and intrinsic incentives on interprofessional primary care teams: protocol for a rapid scoping review Academic Article
Impact of restricted visitation policies in hospitals on patients, family members and healthcare providers during the COVID-19 pandemic: a scoping review protocol Academic Article
Impact of the Surgical Research Methodology Program on Surgical Residents’ Research Profiles Academic Article
Impact of virtual care on health-related quality of life in children with diabetes mellitus: a systematic review protocol Academic Article
Implementation and impact of an online tool used in primary care to improve access to financial benefits for patients: a study protocol Academic Article
Implementing evidence-based recommended practices for the management of patients with mild traumatic brain injuries in Australian emergency care departments: study protocol for a cluster randomised controlled trial Academic Article
Implementing health research through academic and clinical partnerships: a realistic evaluation of the Collaborations for Leadership in Applied Health Research and Care (CLAHRC) Academic Article
Improved up-and-down designs for phase I trials Academic Article
Improving acupuncture research: progress, guidance, and future directions Academic Article
Improving gender equity in critical care medicine: a protocol to establish priorities and strategies for implementation Academic Article
Improving health research among Indigenous Peoples in Canada Academic Article
Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial Academic Article
Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT) Academic Article
Improving reporting of meta-ethnography: the eMERGe reporting guidance Academic Article
Improving reporting of meta‐ethnography: The eMERGe reporting guidance Academic Article
Improving reporting of meta‐ethnography: The eMERGe reporting guidance Academic Article
Improving social justice in observational studies: protocol for the development of a global and Indigenous STROBE-equity reporting guideline Academic Article
Improving the Quality of Abstract Reporting for Phase I Cancer Trials Academic Article
Improving the quality of self-management support in ambulatory cancer care: a mixed-method study of organisational and clinician readiness, barriers and enablers for tailoring of implementation strategies to multisites Academic Article
Improving the reporting of pragmatic trials: an extension of the CONSORT statement Academic Article
Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk Academic Article
In Search of Power and Significance: Issues in the Design and Analysis of Stochastic Cost-Effectiveness Studies in Health Care Academic Article
In the dark The reporting of blinding status in randomized controlled trials Academic Article
Inappropriateness of health care in Canada: a systematic review protocol Academic Article
Inconsistencies in the Methodological Framework Throughout Published Studies in High-Impact Orthopaedic Journals Academic Article
Inconsistent definitions for intention-to-treat in relation to missing outcome data: systematic review of the methods literature Academic Article
Incorporating edoxaban into the choice of anticoagulants for atrial fibrillation Academic Article
Increased Eligibility for Treatment of Chronic Hepatitis C Infection with Shortened Duration of Therapy: Implications for Access to Care and Elimination Strategies in Canada Academic Article
Increased levels of adipokines in bipolar disorder Academic Article
Independent design and conduct of clinical trials Academic Article
Indirect comparison: relative risk fallacies and odds solution Academic Article
Individual opioids, and long- versus short-acting opioids, for chronic noncancer pain Academic Article
Individuals with diabetes preferred that future trials use patient-important outcomes and provide pragmatic inferences Academic Article
Industry-sponsored research Academic Article
Infertility:Treatment of male infertility: is it effective? Review and meta-analyses of published randomized controlled trials Academic Article
Influence of statistician involvement on reporting of randomized clinical trials in medical oncology Academic Article
Influencing advance directive completion rates in non-terminally ill patients: a systematic review Academic Article
Initial data supporting the design of the Candesartan in Heart failure — Assessment of Reduction in Mortality and morbidity (CHARM) programme Academic Article
Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design Academic Article
Innovation and placebos in research: a new design of clinical trial Academic Article
Insights on multimorbidity and associated health service use and costs from three population-based studies of older adults in Ontario with diabetes, dementia and stroke Academic Article
Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas Academic Article
Instructional Design Variations in Internet-Based Learning for Health Professions Education: A Systematic Review and Meta-Analysis Academic Article
Insufficient evidence of the superiority of near-infrared light transillumination over bite-wing digital radiograph for detecting early interproximal carious lesions Academic Article
Insulin therapy in acute coronary syndromes: an appraisal of completed and ongoing randomised trials with important clinical end points Academic Article
Integrated collaborative care teams to enhance service delivery to youth with mental health and substance use challenges: protocol for a pragmatic randomised controlled trial Academic Article
Integrating Clinical Quality Improvement Strategies with Nursing Research Academic Article
Interactive weekly mobile phone text messaging plus motivational interviewing in promotion of breastfeeding among women living with HIV in South Africa: study protocol for a randomized controlled trial Academic Article
Intermittent versus continuous oxygen saturation monitoring for infants hospitalised with bronchiolitis: study protocol for a pragmatic randomised controlled trial Academic Article
International Orthopaedic Multicenter Study in Fracture Care: Coordinating a Large-Scale Multicenter Global Prospective Cohort Study Academic Article
International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019 Academic Article
International law’s effects on health and its social determinants: protocol for a systematic review, meta-analysis, and meta-regression analysis Academic Article
International longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD) Academic Article
International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome and experience measure for hand conditions (HAND-Q) Academic Article
International multiphase mixed methods study protocol to develop a patient-reported outcome instrument for children and adolescents with lower limb deformities Academic Article
International phase 1 study protocol to develop a health state classification system for a preference-based measure for women with breast cancer: the BREAST-Q Utility module Academic Article
International point prevalence study of Intensive Care Unit transfusion practices—Pilot study in the Netherlands Academic Article
Interpretation and inference: towards an understanding of methods Academic Article
Interpretation of relative effects Academic Article
Interpreting trial sequential analysis Academic Article
Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a protocol for a scoping review of the literature and international policies Academic Article
Intracranial and fatal bleeding according to indication for long‐term oral anticoagulant therapy Academic Article
Intraoperative use of balanced crystalloids versus 0.9% saline: a systematic review and meta-analysis of randomised controlled studies Academic Article
Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial Academic Article
Intrathecal hyperbaric versus isobaric bupivacaine for adult non-caesarean-section surgery: systematic review protocol Academic Article
Intravenous immunoglobulin in Rh hemolytic disease of newborn. Academic Article
Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis Academic Article
Introducing the Library of Guidance for Health Scientists (LIGHTS) Academic Article
Introduction to statistical simulations in health research Academic Article
Investigating online interprofessional learning and communication using social network analysis: a study protocol Academic Article
Investigating the appropriateness of different concordance measures in a time‐to‐event setting Academic Article
Investigator experiences with financial conflicts of interest in clinical trials Academic Article
Is NNT now the number needed to traumatize? Academic Article
Is There an Association between STARD Statement Adherence and Citation Rate? Academic Article
Is a Subgroup Claim Believable? Academic Article
Is a subgroup effect believable? Updating criteria to evaluate the credibility of subgroup analyses Academic Article
Is funding source related to study reporting quality in obesity or nutrition randomized control trials in top-tier medical journals? Academic Article
Is there a benefit of low-dose aspirin in assisted reproduction? Academic Article
Is there a place for the crossover design in infertility trials? Academic Article
Is there a role for physician involvement in introducing research to surrogate decision makers in the intensive care unit? (The Approach trial: a pilot mixed methods study) Academic Article
Is there really misuse and abuse of dabigatran? Academic Article
Issues for reporting results Academic Article
Issues in the planning and conduct of randomised trials Academic Article
Issues of Cost and Efficiency in the Design of Reliability Studies Academic Article
Joint WFH‐ISTH session: issues in clinical trial design Academic Article
Justifying the number of animals for each experiment Academic Article
Key Steps in Conducting Systematic Reviews for Underpinning Clinical Practice Guidelines: Methodology of the European Association of Urology Academic Article
Key design considerations for adaptive clinical trials: a primer for clinicians Academic Article
Key gaps in pathologic reporting for appendiceal mucinous neoplasms: time for universal synoptic reporting? Academic Article
Knowledge transfer to clinicians and consumers by the Cochrane Musculoskeletal Group. Academic Article
LCLUC as an entry point for transdisciplinary research – Reflections from an agriculture land use change study in South Asia Academic Article
LEVEL (Logical Explanations & Visualizations of Estimates in Linear mixed models): recommendations for reporting multilevel data and analyses Academic Article
LMW Heparin for Deep Vein Thrombosis Academic Article
Lack of Diversity in Orthopaedic Trials Conducted in the United States Academic Article
Large Sample Formulae for the Expected Number of Matches in a Category Matched Design Academic Article
Learning from failure-rationale and design for a study about discontinuation of randomized trials (DISCO study) Academic Article
Learning what to expect: context-specific control over intertrial priming effects in singleton search Academic Article
Leaving nothing to chance: how to randomize a clinical trial Academic Article
Left Atrial Appendage Occlusion Study (LAAOS): A randomized clinical trial of left atrial appendage occlusion during routine coronary artery bypass graft surgery for long-term stroke prevention Academic Article
Lessons learned from a resident-led clinical trial in obstetrics Academic Article
Leukotriene Antagonists in Asthma Academic Article
Level of Evidence in Orthopaedic Journals Academic Article
Level of clinical evidence presented at the Society for Vascular Surgery Annual Meeting during a 5-year period (2012-2016) Academic Article
Leveraging pragmatic clinical trial design to advance phosphate management in end-stage renal disease Academic Article
Lies, damned lies, and statistics Academic Article
Life course of retrospective harmonization initiatives: key elements to consider Academic Article
Lipid lowering for primary prevention Academic Article
Local estimates of population attributable risk Academic Article
Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies Academic Article
Long-Term Predictive Validity of the Risk Matrix 2000 Academic Article
Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study Academic Article
Long-term risk of recurrence after discontinuing anticoagulants for a first unprovoked venous thromboembolism: protocol for a systematic review and meta-analysis Academic Article
Looking for the evidence: a systematic review of prevention strategies addressing sport and recreational injury among children and youth Academic Article
Low-molecular-weight heparins and unfractionated heparin in the treatment of patients with acute venous thromboembolism: Results of a meta-analysis Academic Article
Lowering of Glucose in Critical care: a randomized pilot trial Academic Article
Lumbar disc disease. Academic Article
Lymphedema in women with breast cancer: characteristics of patients screened for a randomized trial Academic Article
MATERNAL VITAMIN D SUPPLEMENTATION DURING PREGNANCY AND LACTATION TO PROMOTE INFANT GROWTH IN DHAKA, BANGLADESH (MDIG TRIAL): A RANDOMIZED CONTROLLED TRIAL Conference Paper
MRI ventilation abnormalities predict quality-of-life and lung function changes in mild-to-moderate COPD: longitudinal TINCan study Academic Article
Maelstrom Research guidelines for rigorous retrospective data harmonization Academic Article
Magnetic Resonance Imaging Abnormalities and Psychiatric Illness Academic Article
Making Decisions About Prognosis in Evidence-Based Practice Academic Article
Male participation in prevention programmes of mother to child transmission of HIV: a protocol for a systematic review to identify barriers, facilitators and reported interventions Academic Article
Management of acute musculoskeletal pain (excluding low back pain): protocol for a systematic review and network meta-analysis of randomised trials Academic Article
Management of chronic neuropathic pain: a protocol for a multiple treatment comparison meta-analysis of randomised controlled trials Academic Article
Management of non-severe pregnancy hypertension – A summary of the CHIPS Trial (Control of Hypertension in Pregnancy Study) research publications Academic Article
Management of persistent postconcussion symptoms in youth: a randomised control trial protocol Academic Article
Management of type 2 diabetes using non‐insulin glucose‐lowering therapies: a critical appraisal of clinical practice guidelines with the AGREE II instrument Academic Article
Manual für Methoden und Nutzung versorgungsnaher Daten zur Wissensgenerierung Academic Article
Manual therapy for mechanical neck disorders: a systematic review Academic Article
Maternal psychological distress and parenting stress after the birth of a very low-birth-weight infant. Academic Article
Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial Academic Article
Maximizing Oxygen Delivery in High-Risk Surgical Patients Academic Article
McMaster Premium LiteratUre Service (PLUS) performed well for identifying new studies for updated Cochrane reviews Academic Article
Measurement of actions of care-providers in long-term care Academic Article
Measurement of health status Academic Article
Measures assessing attributes of evidence-informed decision-making (EIDM) competence among nurses: a systematic review protocol Academic Article
Measuring and Understanding Treatment Effectiveness in Hand Surgery Academic Article
Measuring asthma control in group studies: do we need airway calibre and rescue β2-agonist use? Academic Article
Measuring behavior change technique delivery and receipt in physical activity behavioral interventions. Academic Article
Measuring the association between behavioural services and outcomes in young children with autism spectrum disorder Academic Article
Measuring the reliability of clinical data: the case for using three observers. Academic Article
Measuring the wellbeing of family caregivers using the time trade-off technique Academic Article
Medicine in the Popular Press: The Influence of the Media on Perceptions of Disease Academic Article
Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol Academic Article
Members of Minority and Underserved Communities Set Priorities for Health Research Academic Article
Mental Health Supplement to the Ontario Health Survey: Methodology Academic Article
Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? Academic Article
Meta-analysis of Pragmatic and Explanatory Trials Chapter
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Meta-analysis: Can We Mix Apples and Oranges? Academic Article
Meta-analysis: well-established and here to stay Academic Article
Meta‐analysis of quantile intervals from different studies with an application to a pulmonary tuberculosis data Academic Article
Method and reporting quality in health professions education research: a systematic review Academic Article
Methodologic Issues in Health Informatics Trials: The Complexities of Complex Interventions Conference Paper
Methodologic issues in trials of antiemetics. Academic Article
Methodologic problems in clinical trials in heart failure Academic Article
Methodological Factors in Studying Medical Graduates Academic Article
Methodological Issues Relevant to Blinding in Physical Medicine and Rehabilitation Research Academic Article
Methodological Issues in Systematic Reviews and Meta-Analyses of Observational Studies in Orthopaedic Research Academic Article
Methodological and Epistemological Considerations in Utilizing Qualitative Inquiry to Develop Interventions Academic Article
Methodological approaches to the design and analysis of nonrandomized intervention studies for the prevention of child and adolescent obesity Academic Article
Methodological challenges in coping and adaptation research. Academic Article
Methodological challenges in design and conduct of randomised controlled trials in acupuncture Academic Article
Methodological design for economic evaluation in Public Access Defibrillation (PAD) trial Academic Article
Methodological idiosyncracies, frameworks and challenges of non-pharmaceutical and non-technical treatment interventions Academic Article
Methodological issues and the impact of age stratification on the proportion of participants with low appendicular lean mass when adjusting for height and fat mass USING LINEAR REGRESSION: RESULTS FROM THE CANADIAN LONGITUDINAL STUDY ON AGING Academic Article
Methodological issues in infertility research Academic Article
Methodological problems in studies of burn survivors and their psychosocial prognosis Academic Article
Methodological problems in the retrospective computation of responsiveness to change: The lesson of Cronbach Academic Article
Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol Academic Article
Methodology for Randomized Trials of Patients With Nonvariceal Upper Gastrointestinal Bleeding: Recommendations From an International Consensus Conference Academic Article
Methodology guideline for clinical studies investigating traditional Chinese medicine and integrative medicine Academic Article
Methodology of the 2009 Survey on Living with Chronic Diseases in Canada—hypertension component Academic Article
Methods and design for the ADAPT study: Application of integrateD Approaches to understanding Physical activity during the Transition to emerging adulthood Academic Article
Methods and guidance on conducting, reporting, publishing and appraising living systematic reviews: a scoping review protocol Academic Article
Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE) Academic Article
Methods for the analysis of bleeding outcomes in randomized trials of PLT transfusion triggers Academic Article
Methods to Summarize Discrete-Choice Experiments in a Systematic Review: A Scoping Review Academic Article
Methods to convert continuous outcomes into odds ratios of treatment response and numbers needed to treat: meta-epidemiological study Academic Article
Methods, applications, interpretations and challenges of interrupted time series (ITS) data: protocol for a scoping review Academic Article
Mine Is Bigger Than Yours Academic Article
Minimal dataset for post‐registration surveillance of new drugs in hemophilia: communication from the SSC of the ISTH Academic Article
Misclassification of Case-Control Studies in Neurosurgery and Proposed Solutions Academic Article
Misleading hepatitis B test results due to intravenous immunoglobulin administration: implications for a clinical trial of rituximab in immune thrombocytopenia Academic Article
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Reporting of randomized controlled trial abstracts in dermatology journals according to CONSORT guidelines Academic Article
Reporting quality of trial protocols improved for non-regulated interventions but not regulated interventions: A repeated cross-sectional study Academic Article
Reporting results of biomonitoring studies Academic Article
Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey Academic Article
Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review Academic Article
Reproductive strategies and seasonal changes in the somatic indices of seven small-bodied fishes in Atlantic Canada in relation to study design for environmental effects monitoring Academic Article
Research Methods for Obtaining Primary Evidence Academic Article
Research Recruitment Practices and Critically Ill Patients. A Multicenter, Cross-Sectional Study (The Consent Study) Academic Article
Research and policy implications of a recently published controlled study in previously untreated haemophilia patients at high risk of inhibitor development Academic Article
Research methods workshop for health professionals in Sierra Leone: an international collaborative project Academic Article
Research on Alzheimer's caregiving in Canada: current status and future directions. Academic Article
Research, Sovereignty and Action: Lessons from a First Nations-Led Study on Aging in Ontario Academic Article
Researching a Best-Practice End-of-Life Care Model for Canada Academic Article
Researching experiences of childhood brain injury: co-constructing knowledge with children through arts-based research methods Academic Article
Resilient Clinical Trial Infrastructure in Response to the COVID-19 Pandemic: Lessons Learned from the TOGETHER Randomized Platform Clinical Trial Academic Article
Resources to facilitate research in advanced practice nursing. Academic Article
Responding to experienced and anticipated discrimination (READ): anti -stigma training for medical students towards patients with mental illness – study protocol for an international multisite non-randomised controlled study Academic Article
Response rates in email vs. mail surveys for urologists: a randomized controlled trial Academic Article
Response to "Potentially Flawed Interpretation of Data by Andriulli et al." Academic Article
Response to Lenert and Kaplan: A Utility Approach to the Assessment of Health-Related Quality of Life Academic Article
Response to Testa: Making Sense of Quality-of-Life Data Academic Article
Response to paper by Lang A, Edwards N, and Fleiszer A Academic Article
Resynchronization/defibrillation for ambulatory heart failure trial: rationale and trial design Academic Article
Retaining participants in community-based health research: a case example on standardized planning and reporting Academic Article
Rethinking measurement of neighborhood in the context of health research Academic Article
Retrieving randomized controlled trials from medline: a comparison of 38 published search filters Academic Article
Review article: Medical education research: an overview of methods Academic Article
Reviewer agreement trends from four years of electronic submissions of conference abstract Academic Article
Reviewing the research methods literature: principles and strategies illustrated by a systematic overview of sampling in qualitative research Academic Article
Reviewing the reviewers: the quality of reporting in three secondary journals. Academic Article
Revisiting the time course of inter-trial feature priming in singleton search Academic Article
Risk factors for low BMD in healthy men age 50 years or older: a systematic review Academic Article
Risk factors for unintentional injuries due to falls in children aged 0-6 years: a systematic review Academic Article
Risk of heart failure and edema associated with the use of pregabalin: a systematic review Academic Article
Risk of recurrent venous thromboembolism after stopping treatment in cohort studies: recommendation for acceptable rates and standardized reporting Academic Article
Risk-Scoring Tool for respiratory syncytial virus prophylaxis in premature infants born at 33–35 completed weeks’ gestational age in Canada Academic Article
Risk-taking behaviors and falls in community-dwelling older adults: a scoping review protocol Academic Article
Rivaroxaban for Preventing Venous Thromboembolism in High-Risk Ambulatory Patients with Cancer: Rationale and Design of the CASSINI Trial Academic Article
Robust bivariate random-effects model for accommodating outlying and influential studies in meta-analysis of diagnostic test accuracy studies Academic Article
Role of patient selection and trial stimulation for spinal cord stimulation therapy for chronic non-cancer pain: a comprehensive narrative review Academic Article
SELIMETRY—a multicentre I-131 dosimetry trial: a clinical perspective Academic Article
SOLLID – a single centre study to develop methods to investigate the effects of low radiation doses within nuclear medicine, to enable multicentre epidemiological investigations Academic Article
STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies Academic Article
SUNSET: Stereotactic Radiation for Ultracentral Non–Small-Cell Lung Cancer—A Safety and Efficacy Trial Academic Article
Safety and efficacy of perioperative benzodiazepine administration: study protocol for a systematic review and meta-analysis Academic Article
Sample Size and Power in Psychiatric Research^* Academic Article
Sample Size in Clinical Research: When is Enough Enough? Academic Article
Sample size and optimal designs for reliability studies Academic Article
Sample size and power considerations in network meta-analysis Academic Article
Sample size calculations: should the emperor's clothes be off the peg or made to measure? Academic Article
Sample size determination for bibliographic retrieval studies Academic Article
Sample sizes for clinical trials using sputum eosinophils as a primary outcome Academic Article
Scales to Assess the Quality of Randomized Controlled Trials: A Systematic Review Conference Paper
Scanning and form-contingent color aftereffects. Academic Article
Science, Language, Intuition, and the Many Meanings of Quality of Life Academic Article
Scientific Requirements for Diagnostic Tests in Gastroenterology Academic Article
Scoping reviews: reinforcing and advancing the methodology and application Academic Article
Scoping the Field: Identifying Key Research Priorities in HIV and Rehabilitation Academic Article
Screening for depression in women during pregnancy or the first year postpartum and in the general adult population: a protocol for two systematic reviews to update a guideline of the Canadian Task Force on Preventive Health Care Academic Article
Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial Academic Article
Seamless Designs: Current Practice and Considerations for Early-Phase Drug Development in Oncology Academic Article
Search filters can find some but not all knowledge translation articles in MEDLINE: an analytic survey Academic Article
Searching for rigour in the reporting of mixed methods population health research: a methodological review Academic Article
Searching the scientific literature. Academic Article
Second Vasovagal Pacemaker Study (VPS II): Rationale, Design, Results, and Implications for Practice and Future Clinical Trials Academic Article
Seeing Like a Research Project: Producing “High-Quality Data” in AIDS Research in Malawi Academic Article
Seeing the forests and the trees—innovative approaches to exploring heterogeneity in systematic reviews of complex interventions to enhance health system decision-making: a protocol Academic Article
Selecting and Appraising Studies for a Systematic Review Academic Article
Selecting the Optimal Level of Clustering: An Approach to Trial Design Decision Making Academic Article
Selection and combination of outcome measures. Academic Article
Selection of patients for randomized controlled trials: Implications of wide or narrow eligibility criteria Academic Article
Selective quotation of evidence in vaccines research Academic Article
Self-Reported Musculoskeletal Disorders Among Visiting and Office Home Care Workers Academic Article
Senior GRADE methodologists encounter challenges as part of WHO guideline development panels: an inductive content analysis Academic Article
Senior high-cost healthcare users’ resource utilization and outcomes: a protocol of a retrospective matched cohort study in Canada Academic Article
Sequential Monte Carlo for response adaptive randomized trials Academic Article
Serial Habituation in Two-, Three-, and Four-Month-Old Infants Academic Article
Setting up a clinical trial in care homes: challenges encountered and recommendations for future research practice Academic Article
Sex Offender Populations and Clinical Efficacy Academic Article
Sex, Gender and Health: Mapping the Landscape of Research and Policy Academic Article
Shadow and substance: values and knowledge. Academic Article
Sharing interim trial results by the Data Safety Monitoring Board with those responsible for the trial’s conduct and progress: a narrative review Academic Article
Should Observational Studies Be a Thing of the Past? Academic Article
Should children be screened to undergo early treatment for otitis media with effusion? A systematic review of randomized trials Academic Article
Should physicians initiate β‑blocker therapy in patients undergoing non‑cardiac surgery? Insights from the POISE trial Academic Article
Should study subjects see their previous responses: Data from a randomized control trial Academic Article
Should study subjects see their previous responses? Academic Article
Similarities, reliability and gaps in assessing the quality of conduct of systematic reviews using AMSTAR-2 and ROBIS: systematic survey of nutrition reviews Academic Article
Simple compared to covariate-constrained randomization methods in balancing baseline characteristics: a case study of randomly allocating 72 hemodialysis centers in a cluster trial Academic Article
Simulation Models of Misclassification Error for Single Thresholds of High-Sensitivity Cardiac Troponin I Due to Assay Bias and Imprecision Academic Article
Simulation study to determine the impact of different design features on design efficiency in discrete choice experiments Academic Article
Single session pre-post randomized intervention studies: The good, bad, and ugly Academic Article
Skew‐normal random‐effects model for meta‐analysis of diagnostic test accuracy (DTA) studies Academic Article
Sleep duration and eating behaviours in youth: a scoping review protocol Academic Article
Sleep to lower elevated blood pressure: study protocol for a randomized controlled trial Academic Article
Sleep, biological rhythms and anxiety in the perinatal period: a systematic review protocol Academic Article
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Society of Interventional Radiology Research Reporting Standards for Prostatic Artery Embolization Academic Article
SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX-trial): study design of an international multicenter randomized double-blinded controlled trial of high dose sodium-selenite administration in high-risk cardiac surgical patients Academic Article
Some ethical and design challenges of screening programs and screening tests Academic Article
Sources of bias in diagnostic accuracy studies and the diagnostic process Academic Article
Specialized Inpatient Trauma Treatment for Adults Abused as Children: A Follow-Up Study Academic Article
Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid Academic Article
Stakeholder Engagement in Trial Design: Survey of Visitors to Critically Ill Patients Regarding Preferences for Outcomes and Treatment Options during Weaning from Mechanical Ventilation Academic Article
Stakeholder Perspectives of Attributes and Features of Context Relevant to Knowledge Translation in Health Settings: A Multi-Country Analysis Academic Article
Standard 5: Selection, Measurement, and Reporting of Outcomes in Clinical Trials in Children Academic Article
Standardised Outcomes in Nephrology – Chronic Kidney Disease (SONG-CKD): a protocol for establishing a core outcome set for adults with chronic kidney disease who do not require kidney replacement therapy Academic Article
Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the canadian biomarker integration network in depression Academic Article
Standardized reporting of bleeding complications for clinical investigations in acute coronary syndromes: A proposal from the Academic Bleeding Consensus (ABC) Multidisciplinary Working Group Academic Article
Standards of Proof, Standards of Practice, and Proof of Standards: A Tale of Two Trials Academic Article
Starting prophylaxis for venous thromboembolism postoperatively Academic Article
Statistical approaches to harmonize data on cognitive measures in systematic reviews are rarely reported Academic Article
Statistical issues in the design and analysis of expertise‐based randomized clinical trials Conference Paper
Statistical issues in the use of dynamic allocation methods for balancing baseline covariates Academic Article
Statistical methodologies to pool across multiple intervention studies Academic Article
Statistical reporting deficiencies in environmental toxicology Academic Article
Statistical significance and fragility criteria for assessing a difference of two proportions Academic Article
Statistics Commentary Series Academic Article
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Statistics Commentary Series. Commentary No. 42: Minimization Academic Article
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Stellate ganglion block for non-pain indications: a scoping review Academic Article
Steroid use in critically ill septic patients: acknowledging the uncertainty Academic Article
Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial Academic Article
Steroids and Spinal Cord Injury Academic Article
Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial Academic Article
Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials Academic Article
Stories, voices, and explanations: How qualitative methods may help augment emergency medicine research Academic Article
Strategic use of new generation antidepressants for depression: SUN(^_^) D protocol update and statistical analysis plan Academic Article
Strategies and Methods for Research on Sex Differences in Brain and Behavior Academic Article
Strategies for prevention of soccer related injuries: a systematic review Academic Article
Stress Physiology in Infancy and Early Childhood: Cortisol Flexibility, Attunement and Coordination Academic Article
Student-designed clinical trials: evaluating self-directed learning in pharmacology Academic Article
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Study Design and Hierarchy of Evidence for Surgical Decision Making Academic Article
Study Design for the Evaluation of Diagnostic Tests Academic Article
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Study design attributes influenced patients' willingness to participate in clinical research: a randomized vignette-based study Academic Article
Study design considerations for assessing the health of fish populations impacted by agriculture in developing countries: a Sri Lankan case study Academic Article
Study protocol for a 2-year longitudinal study of positive youth development at an urban sport for development facility Academic Article
Study protocol for a randomized, blinded, controlled trial of ketamine for acute painful crisis of sickle cell disease Academic Article
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Study protocol for two complementary trials of non-steroidal or opioid analgesia use for children aged 6 to 17 years with musculoskeletal injuries (the No OUCH study) Academic Article
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Subcutaneous IGF-1 is not beneficial in 2-year ALS trial Academic Article
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Surgical versus Nonsurgical Treatment for Back Pain Academic Article
Survey Design in Orthopaedic Surgery: Getting Surgeons to Respond Academic Article
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Survival distributions impact the power of randomized placebo-phase design and parallel groups randomized clinical trials Academic Article
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The study of health assessment and risk in ethnic groups (SHARE): Rationale and design Academic Article
The use of co-design in developing physical activity interventions for older adults: a scoping review protocol Academic Article
The use of surrogate endpoints in clinical trials: focus on clinical trials in cardiovascular diseases Academic Article
The value of information and optimal clinical trial design Academic Article
The ‘Expanded HIV care in opioid substitution treatment’ (EHOST) cluster-randomized, stepped-wedge trial: A study protocol Academic Article
The ‘goddess of randomisation’ in small samples Academic Article
The “parallel-cohort RCT”: Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism Academic Article
Then-of-1 Randomized Controlled Trial: Clinical Usefulness Academic Article
Therapeutic equivalence: all studies are not created equal. Academic Article
Thiazides for Patients with Recurrent Calcium Stones: Still an Open Question Academic Article
Thinking Small: Research Designs Appropriate for Clinical Practice Academic Article
Three challenges described for identifying participants with missing data in trials reports, and potential solutions suggested to systematic reviewers Academic Article
Thrombolysis Compared With Heparin for the Initial Treatment of Pulmonary Embolism Academic Article
Thromboprophylaxis using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone in critically ill patients: study protocol for a randomized controlled trial Academic Article
Thrombosis prophylaxis in the acutely ill medical patient: insights from the prophylaxis in medical patients with enoxaparin (MEDENOX) trial Academic Article
Time and Expected Value of Sample Information Wait for No Patient Academic Article
Time for reflection on patient’s safety in healthcare Academic Article
Time to rethink clinically important outcomes in platelet transfusion trials Academic Article
Time-dependent analysis in CHF follow-up Academic Article
Tips for learners of evidence-based medicine: 2. Measures of precision (confidence intervals) Academic Article
Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic) Academic Article
Tips for learners of evidence-based medicine: 4. Assessing heterogeneity of primary studies in systematic reviews and whether to combine their results Academic Article
Tips on overlapping confidence intervals and univariate linear models Academic Article
To the point: a primer on medical education research Academic Article
To “ P ” or not to “ P ”-That is not the question Academic Article
Tolerability and efficacy of docetaxel in older men with metastatic castrate-resistant prostate cancer (mCRPC) in the TAX 327 trial Academic Article
Tools for assessing the scalability of innovations in health: a systematic review Academic Article
Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis Academic Article
Towards Complete and Accurate Reporting of Studies of Diagnostic Accuracy: The STARD Initiative Academic Article
Towards Transparency in the Selection of Published Health Utility Inputs in Cost-Utility Analyses: The Health Utility Application Tool (HAT) Academic Article
Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus Academic Article
Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative Academic Article
Towards systematic reviews that inform health care management and policy-making Academic Article
Traditional knowledge-based lifestyle interventions in the prevention of obesity and type 2 diabetes in Indigenous children in Canada: a systematic review protocol Academic Article
Trajectory research in children on the autism spectrum: a scoping review protocol Academic Article
Tranexamic acid in cardiac surgery: a systematic review and meta-analysis (protocol) Academic Article
Transcending the Male–Female Binary in Biomedical Research: Constellations, Heterogeneity, and Mechanism When Considering Sex and Gender Academic Article
Transepithelial versus epithelium-off corneal collagen cross-linking for corneal ectasia: protocol for a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials Academic Article
Transesophageal Echocardiography to Guide Cardioversion in Patients with Atrial Fibrillation Academic Article
Transitional care quality indicators to assess quality of care following hospitalisation for chronic obstructive pulmonary disease and heart failure: a systematic review protocol Academic Article
Trauma Resident Exposure in Canada and Operative Numbers (TraumaRECON): a study protocol for a national multicentre study of operative, nonoperative and structured educational exposures in Canada Academic Article
Treating the right patient at the right time: Access to cardiovascular nuclear imaging Academic Article
Treatment allocation in clinical trials Academic Article
Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial Academic Article
Treatment goal setting for complex patients: protocol for a scoping review Academic Article
Treatment-Independent Pregnancy among Infertile Couples Academic Article
Trends and recommendations in studies of mouse airway function Academic Article
Trends in the application of dynamic allocation methods in multi-arm cancer clinical trials Academic Article
Triage Tool Inter-rater Reliability: A Comparison of Live Versus Paper Case Scenarios Academic Article
Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed Academic Article
Trial sample size, but not trial quality, is associated with positive study outcome Academic Article
Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses Academic Article
Trial to re-evaluate ultrasound in the treatment of tibial fractures (TRUST): a multicenter randomized pilot study Academic Article
Two alternatives versus the standard Grading of Recommendations Assessment, Development and Evaluation (GRADE) summary of findings (SoF) tables to improve understanding in the presentation of systematic review results: a three-arm, randomised, controlled, non-inferiority trial Academic Article
Two doses of rivaroxaban versus aspirin for prevention of recurrent venous thromboembolism Academic Article
Type-II Error Rates (Beta Errors) of Randomized Trials in Orthopaedic Trauma Academic Article
Uncertainties about the need for ethics approval in Switzerland: a mixed-methods study Academic Article
Underestimation of pain by health-care providers: towards a model of the process of inferring pain in others. Academic Article
Understanding Measures of Association Academic Article
Understanding Measures of Association: A Primer With Examples From Rehabilitation Research. Academic Article
Understanding Palliative Care on the Heart Failure Care Team: An Innovative Research Methodology Academic Article
Understanding and Enhancing Sepsis Survivorship. Priorities for Research and Practice Academic Article
Understanding how context and culture in six communities can shape implementation of a complex intervention: a comparative case study Academic Article
Understanding the Conceptualization and Operationalization of Trauma‐Informed Care Within and Across Systems: A Critical Interpretive Synthesis Academic Article
Unicorns Do Exist: A Tutorial on “Proving” the Null Hypothesis Academic Article
Unmet Needs and Challenges in Clinical Research of Intracerebral Hemorrhage Academic Article
Unreliable mtDNA data due to nuclear insertions: a cautionary tale from analysis of humans and other great apes Academic Article
Unsettling Knowledge Synthesis Methods Using Institutional Ethnography: Reflections on the Scoping Review as a Critical Knowledge Synthesis Tool Academic Article
Unspoken phenomena: using the photovoice method to enrich phenomenological inquiry Academic Article
Updating the Canadian clinical practice guideline for managing pediatric obesity: a protocol Academic Article
Use and Interpretation of Composite End Points in Orthopaedic Trials Academic Article
Use of GRADE in Australian clinical practice guidelines: a methodological review protocol Academic Article
Use of Q-Methodology to Identify Nursing Faculty Viewpoints of a Collaborative BScN Program Experience Academic Article
Use of health systems and policy research evidence in the health policymaking in eastern Mediterranean countries: views and practices of researchers Academic Article
Use of the Principles of Design Thinking to Address Limitations of Digital Mental Health Interventions for Youth: Viewpoint Academic Article
User's Guide to a Prognostic Study on an Orthopaedic Implant Academic Article
User's guide to the Chiropractic Literature-IB: how to use an article about therapy Academic Article
User's guide to the chiropractic literature-1a: how to use an article about therapy Academic Article
User's guide to the orthopaedic literature: how to use a systematic literature review. Academic Article
Users' guide to detecting misleading claims in clinical research reports Academic Article
Users' guide to evidence-based surgery: how to use an article evaluating surgical interventions. Evidence-Based Surgery Working Group. Academic Article
Users' guide to the surgical literature. How to assess a randomized controlled trial in surgery. Academic Article
Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? Evidence-Based Medicine Working Group Academic Article
Users’ guide to the surgical literature: how to assess a noninferiority trial Academic Article
Users’ guide to the surgical literature: how to assess an article using surrogate end points Academic Article
User’s guide to the chiropractic literature-IA: how to use an article about therapy Academic Article
Using GRADE for evaluating the quality of evidence in hyperbaric oxygen therapy clarifies evidence limitations Academic Article
Using Institutional Ethnography to Understand the Production of Health Care Disparities Academic Article
Using Meta-Analysis in Psychiatric Research Academic Article
Using baseline measurements in the two-period crossover clinical trial Academic Article
Using evidence from randomized trials in fertility practice Academic Article
Using the Maximum Test Statistic in the Two-Period Crossover Clinical Trial Academic Article
Utility of Qualitative Research Findings in Evidence-Based Public Health Practice Academic Article
VITATOPS, the VITAmins TO Prevent Stroke Trial: Rationale and Design of a Randomised Trial of B-Vitamin Therapy in Patients with Recent Transient Ischaemic Attack or Stroke (NCT00097669) (ISRCTN74743444) Academic Article
Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project) Academic Article
Validated questionnaires should not be modified Academic Article
Validation of an index of the quality of review articles Academic Article
Validation of the Imperial College Surgical Assessment Device (ICSAD) for labour epidural placement Academic Article
Validity of a novel method to measure vertical oscillation during running using a depth camera Academic Article
Value of information methods for planning and analyzing clinical studies optimize decision making and research planning Academic Article
Values and other decisional factors regarding treatment of hypercalcaemia of malignancy: a systematic review protocol Academic Article
Variable participation of knowledge users in cancer health services research: results of a multiple case study Academic Article
Variations in stepped-wedge cluster randomized trial design: Insights from the Patient-Centered Care Transitions in Heart Failure trial Academic Article
Varied overground walking task practice versus body weight supported treadmill training in community dwelling adults within one year of stroke: a randomized controlled trial Conference Paper
Varied overground walking-task practice versus body-weight-supported treadmill training in ambulatory adults within one year of stroke: a randomized controlled trial protocol Academic Article
Vasopressin or Epinephrine for Out-of-Hospital Cardiac Arrest Academic Article
Vasopressor use following traumatic injury: protocol for a systematic review Academic Article
Virtue, progress and practice Academic Article
Visual analog scales: do they have a role in the measurement of preferences for health states? Academic Article
Vitamin D’s role in health and disease: How does the present inform our understanding of the past? Academic Article
Vitamin E and bronchopulmonary dysplasia Academic Article
Vitamin K antagonists and cancer: rebuttal Academic Article
Waiver of Informed Consent in Pediatric Resuscitation Research: A Systematic Review Academic Article
Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial Academic Article
What Do Reported Learning Curves Mean for Orthopaedic Surgeons? Academic Article
What Does the Evidence Tell Us About Design of Future Treatment Trials for Whiplash-Associated Disorders? Academic Article
What Theories and Methods From Relationship Research Can Contribute to Sex Research Academic Article
What are the best methodologies for rapid reviews of the research evidence for evidence-informed decision making in health policy and practice: a rapid review Academic Article
What are we confident about? Academic Article
What counts as patient-important upper gastrointestinal bleeding in the ICU? A mixed-methods study protocol of patient and family perspectives Academic Article
What do we mean by web-based learning? A systematic review of the variability of interventions Academic Article
What does this study test, and why? Academic Article
What is Wrong With Systematic Reviews and Meta-Analyses: If You Want the Right Answer, Ask the Right Question! Academic Article
What is a network meta-analysis and how can we use it to inform clinical practice? Academic Article
What is “quality of evidence” and why is it important to clinicians? Academic Article
What makes public health studies ethical? Dissolving the boundary between research and practice Academic Article
What risks should be permissible in controlled human infection model studies? Academic Article
What should be reported in a methods section on utility assessment? Academic Article
What to do with all the AGREEs? The AGREE portfolio of tools to support the guideline enterprise Academic Article
When is a randomised controlled trial health equity relevant? Development and validation of a conceptual framework Academic Article
When is informed consent required in cluster randomized trials in health research? Academic Article
When is it safe to stop for safety? Academic Article
When to replicate systematic reviews of interventions: consensus checklist Academic Article
Where Would You Turn for Help? Older Adults' Awareness of Community Support Services Academic Article
Who's minding the shop? The role of Canadian research ethics boards in the creation and uses of registries and biobanks Academic Article
Why observational studies are key? Health status outcomes and clinical care pathways. Academic Article
Why recent editorial review articles regarding randomized methodology do not reflect reality Academic Article
Willingness-to-pay (WTP): the new-old kid on the economic evaluation block. Academic Article
Women's Views of Their Experiences in the CHIPS (Control of Hypertension in Pregnancy Study) Pilot Trial Academic Article
Women's and care providers' perspectives of quality prenatal care: a qualitative descriptive study Academic Article
Women’s Experiences of Participating in the Early External Cephalic Version 2 Trial Academic Article
Working in the Margins: Women's Experiences of Stress and Occupational Health Problems in Part-Time and Casual Retail Jobs Academic Article
Writing place: a comparison of nursing research and health geography Academic Article
Written informed consent and selection bias in observational studies using medical records: systematic review Academic Article
X-ray cross correlation analysis uncovers hidden local symmetries in disordered matter Academic Article
XANTUS: rationale and design of a noninterventional study of rivaroxaban for the prevention of stroke in patients with atrial fibrillation Academic Article
Ximelagatran for Secondary Prevention of Venous Thromboembolism Academic Article
Ximelagatran or warfarin in atrial fibrillation? Academic Article
[10 years of stagnant clinical research in the Italian academic context.]. Academic Article
[Four numbers and a bit more basic knowledge of mathematics]. Academic Article
[How to carry out a good epidemiological study. I. Preparation of a study]. Academic Article
[How to carry out a good epidemiological study. II. Collection of data, writing of the report, evaluation of the completed work]. Academic Article
[Risk of bias assessment: (7) Assessing Bias in Studies of Prognostic Factors]. Academic Article
[Risk of ovarian cancer in women treated for infertility]. Academic Article
[Risk of ovarian cancer in women treated for infertility]. Academic Article
[The number needed to treat (NNT) and the number needed to harm (NNH)]. Academic Article
β-Blockers in sepsis: protocol for a systematic review and meta-analysis of randomised control trials Academic Article
β2-agonists Academic Article
‘Selective dorsal rhizotomy studies’ Academic Article
‘The problem is small enough, the problem is big enough’: a qualitative study of health technology assessment and public policy on drug funding decisions for children Academic Article
“Nothing About Us, without Us.” How Community-Based Participatory Research Methods Were Adapted in an Indigenous End-of-Life Study Using Previously Collected Data Academic Article
“Push” versus “Pull” for mobilizing pain evidence into practice across different health professions: A protocol for a randomized trial Academic Article

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