COST AND EFFICIENCY IN THE CHOICE OF MATCHED AND UNMATCHED CASE-CONTROL STUDY DESIGNS1

This study compares matched and unmatched case-control designs in terms of the precision with which one can estimate an exposure-disease association while controlling for the effects of a confounding variable. Provision is made for the cost of the matching process by calculating the reduction in the number of controls that can be studied for fixed study cost. The purpose is to provide epidemiologists with guidelines and quantitative procedures …