Journal article
Improving analysis of cognitive outcomes in cardiovascular trials using different statistical approaches
Abstract
BackgroundThe Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) questionnaires are commonly used to measure global cognition in clinical trials. Because these scales are discrete and bounded with ceiling and floor effects and highly skewed, their analysis as continuous outcomes presents challenges. Normality assumptions of linear regression models are usually violated, which may result in failure to detect …
Authors
Lee SF; Whiteley W; Bosch J; Sherlock L; Cukierman-Yaffe T; O’Donnell M; Eikelboom JW; Gerstein HC; Bangdiwala SI; Muniz-Terrera G
Journal
Trials, Vol. 25, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13063-024-08482-2
ISSN
1468-6708