Journal article
Systematic reviewers neglect bias that results from trials stopped early for benefit
Abstract
OBJECTIVE: To examine how authors of systematic reviews that include randomized clinical trials (RCTs) that are stopped early for benefit (truncated RCTs-tRCTs) address the potential for overestimation of treatment effects and to determine the weight of the tRCTs on pooled results.
STUDY DESIGN AND SETTING: We searched the Cochrane Library and MEDLINE and evaluated systematic reviews that include at least one tRCT. We documented approaches that …
Authors
Bassler D; Ferreira-Gonzalez I; Briel M; Cook DJ; Devereaux PJ; Heels-Ansdell D; Kirpalani H; Meade MO; Montori VM; Rozenberg A
Journal
Journal of Clinical Epidemiology, Vol. 60, No. 9, pp. 869–873
Publisher
Elsevier
Publication Date
September 2007
DOI
10.1016/j.jclinepi.2006.12.006
ISSN
0895-4356