Journal article
Observed intervention effects for mortality in randomised clinical trials: a methodological study protocol
Abstract
INTRODUCTION: It is essential to choose a realistic anticipated intervention effect when calculating a sample size for a randomised clinical trial. Unfortunately, anticipated intervention effects are often inflated, when compared with the 'true' intervention effects. This is documented for mortality in critical care trials. A similar pattern might exist across different medical specialties. This study aims to estimate the range of observed …
Authors
Hansen ML; Jørgensen CK; Thabane L; Rulli E; Biagioli E; Chiaruttini M; Mbuagbaw L; Mathiesen O; Gluud C; Jakobsen JC
Journal
BMJ Open, Vol. 13, No. 6,
Publisher
BMJ
Publication Date
6 2023
DOI
10.1136/bmjopen-2023-072550
ISSN
2044-6055