Journal article
Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review
Abstract
OBJECTIVE: To study how composite outcomes, which have combined several components into a single measure, are defined, reported, and interpreted.
DESIGN: Systematic review of parallel group randomised clinical trials published in 2008 reporting a binary composite outcome. Two independent observers extracted the data using a standardised data sheet, and two other observers, blinded to the results, selected the most important component.
Authors
Cordoba G; Schwartz L; Woloshin S; Bae H; Gøtzsche PC
Journal
The BMJ, Vol. 341, No. aug18 3,
Publisher
BMJ
Publication Date
August 18, 2010
DOI
10.1136/bmj.c3920
ISSN
0959-8138