Journal article
Problems of stopping trials early
Abstract
When interim analyses of randomised trials suggest large beneficial treatment effects, investigators sometimes terminate trials earlier than planned. Gordon H Guyatt and colleagues show how this practice can have far reaching and harmful consequences
Authors
Guyatt GH; Briel M; Glasziou P; Bassler D; Montori VM
Journal
The BMJ, Vol. 344, No. jun15 1,
Publisher
BMJ
Publication Date
June 15, 2012
DOI
10.1136/bmj.e3863
ISSN
0959-8138