Journal article
Exploring design-related bias in clinical studies on receptor genetic polymorphism of hypertension
Abstract
BACKGROUND AND OBJECTIVES: Although several candidate genes of Renin-Angiotensin-Aldosterone System (RAAS) have been investigated, the gene-drug relationship remains unclear. The objective was to appraise the elements of research methodology and explore potential biases, which may be contributing to discordant results in the gene-drug interaction assessment for RAAS.
METHODS: Systematic review of studies involving candidate polymorphisms, …
Authors
Farahani P; Dolovich L; Levine M
Journal
Journal of Clinical Epidemiology, Vol. 60, No. 1, pp. 1.e1–1.e11
Publisher
Elsevier
Publication Date
1 2007
DOI
10.1016/j.jclinepi.2006.04.002
ISSN
0895-4356