GRADE Leitlinien: 5. Einschätzung der Qualität der Evidenz – Publikationsbias Academic Article uri icon

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abstract

  • In the GRADE approach, randomized trials are classified as high quality evidence and observational studies as low quality evidence but both can be rated down if a body of evidence is associated with a high risk of publication bias. Even when individual studies included in best-evidence summaries have a low risk of bias, publication bias can result in substantial overestimates of effect. Authors should suspect publication bias when available evidence comes from a number of small studies most of which have been commercially funded. A number of approaches based on examination of the pattern of data are available to help assess publication bias. The most popular of these is the funnel plot; all, however, have substantial limitations. Publication bias is likely frequent, and caution in the face of early results, particularly with small sample size and number of events, is warranted.

authors

  • Nolting, Alexandra
  • Perleth, Matthias
  • Langer, Gero
  • Meerpohl, Joerg J
  • Gartlehner, Gerald
  • Kaminski-Hartenthaler, Angela
  • Schunemann, Holger

publication date

  • January 2012