Journal article
Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery
Abstract
BACKGROUND: Noncardiac surgery is associated with significant cardiovascular mortality, morbidity, and cost. Small trials of beta-blockers suggest that they may prevent cardiovascular events in patients undergoing noncardiac surgery, but trial results are inconclusive. We have initiated the POISE trial to definitively establish the effects of beta-blocker therapy in patients undergoing noncardiac surgery.
METHODS: The POISE trial is a blinded, …
Authors
Devereaux PJ; Yang H; Guyatt GH; Leslie K; Villar JC; Monteri VM; Choi P; Giles JW; Yusuf S
Journal
American Heart Journal, Vol. 152, No. 2, pp. 223–230
Publisher
Elsevier
Publication Date
8 2006
DOI
10.1016/j.ahj.2006.05.019
ISSN
0002-8703
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Adrenergic beta-AntagonistsAgedCardiovascular DiseasesDelayed-Action PreparationsDigestive System DiseasesFemaleHeart ArrestHumansInfusions, IntravenousMaleMetoprololMiddle AgedMulticenter Studies as TopicMyocardial InfarctionOutcome Assessment, Health CarePatient SelectionRandomized Controlled Trials as TopicResearch DesignVascular Diseases