Journal article
Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis
Abstract
OBJECTIVES: To discuss theoretical and practical aspects relating to the design of animal studies investigating the efficacy of novel therapeutic agents for the treatment of sepsis, and to make explicit the process whereby these studies can be evaluated for the purpose of designing clinical trials in humans.
DATA SOURCES: Relevant articles from the pertinent literature were reviewed.
Authors
Piper RD; Cook DJ; Bone RC; Sibbald WJ
Journal
Critical Care Medicine, Vol. 24, No. 12, pp. 2059–2070.
Publisher
Wolters Kluwer
Publication Date
December 1996
DOI
10.1097/00003246-199612000-00021
ISSN
0090-3493