Journal article
Corticosteroids in sepsis: an updated systematic review and meta-analysis (protocol)
Abstract
INTRODUCTION: Sepsis is associated with a dysregulated host response to infection and impaired endogenous corticosteroid metabolism. As such, therapeutic use of exogenous corticosteroids is a promising adjunctive intervention. Despite a large number of trials examining this research question, uncertainty persists regarding the effect of corticosteroids on survival in sepsis. Several large randomised controlled trials have been published …
Authors
Rochwerg B; Oczkowski S; Siemieniuk RA; Menon K; Szczeklik W; English S; Agoritsas T; Belley-Cote E; D’Aragon F; Alhazzani W
Journal
BMJ Open, Vol. 7, No. 6,
Publisher
BMJ
Publication Date
June 2017
DOI
10.1136/bmjopen-2017-016847
ISSN
2044-6055