Confidence interval of risk difference by different statistical methods and its impact on the study conclusion in antibiotic non-inferiority trials

BackgroundNumerous statistical methods can be used to calculate the confidence interval (CI) of risk differences. There is consensus in previous literature that the Wald method should be discouraged. We compared five statistical methods for estimating the CI of risk difference in terms of CI width and study conclusion in antibiotic non-inferiority trials.MethodsIn a secondary analysis of a systematic review, we included non-inferiority trials …