Principles of Designing a Cohort Study in Orthopaedics Academic Article

abstract

• A well-designed and executed prospective cohort study can provide high-quality evidence in the evaluation of the effectiveness of surgical interventions. In designing a cohort study to evaluate orthopaedic interventions, it is important to recognize the limitations of the design as well as the methodological features that can be incorporated to strengthen the validity of the conclusions. In this article, we discuss the importance of the appropriate selection of participants for a control group, the management of confounders, the selection of outcomes with established measurement properties (reliability, validity, and sensitivity to change), the blinded assessment of outcomes, and the impact of nonparticipants and patients lost to follow-up.

authors

• Bryant, Dianne
• Willits, Kevin
• Hanson, Beate P

status

• published 

publication date

• May 1, 2009

has subject area

• 0903 Biomedical Engineering (FoR)
• 1103 Clinical Sciences (FoR)
• Cohort Studies (MeSH)
• Confounding Factors, Epidemiologic (MeSH)
• Evidence-Based Medicine (MeSH)
• Humans (MeSH)
• Orthopedics (MeSH)
• Orthopedics (Science Metrix)
• Outcome Assessment, Health Care (MeSH)
• Patient Dropouts (MeSH)
• Prospective Studies (MeSH)
• Randomized Controlled Trials as Topic (MeSH)
• Reproducibility of Results (MeSH)
• Research Design (MeSH)

published in

• Journal of Bone and Joint Surgery: American Volume  Journal

keywords

• Cohort Studies
• Confounding Factors, Epidemiologic
• Evidence-Based Medicine
• Humans
• Orthopedics
• Outcome Assessment, Health Care
• Patient Dropouts
• Prospective Studies
• Randomized Controlled Trials as Topic
• Reproducibility of Results
• Research Design

Digital Object Identifier (DOI)

• 10.2106/jbjs.h.01597

PubMed ID

• 19411494

start page

• 10

end page

• 14

volume

• 91

issue

• Supplement_3