Journal article
Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE Study. Microalbuminuria, cardiovascular, and renal outcomes. Heart Outcomes Prevention Evaluation.
Abstract
OBJECTIVE: To describe the rationale and design of a large international study (microalbuminuria, cardiovascular, and renal outcomes [MICRO] in the HOPE [Heart Outcomes Prevention Evaluation] study) of an ACE inhibitor and vitamin E for the prevention of diabetic nephropathy (DN) and cardiovascular disease (CVD) in patients with diabetes and microalbuminuria (MA). RESEARCH DESIGN AND METHODS: A total of 3,657 diabetic subjects, including 1,129 …
Authors
Gerstein HC; Bosch J; Pogue J; Taylor DW; Zinman B; Yusuf S
Journal
Diabetes Care, Vol. 19, No. 11, pp. 1225–1228
Publication Date
11 1996
DOI
10.2337/diacare.19.11.1225
ISSN
0149-5992