Journal article
Prefrontal Cortex 5-HT2 Receptors in Depression: An 18FSetoperone PET Imaging Study
Abstract
OBJECTIVE: Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology of depression. Of 5-HT receptor abnormalities reported, the most replicated finding is increased 5-HT2 receptor binding in the postmortem prefrontal cortex of depressed suicide victims. The extent to which these findings exist in depressed persons without recent suicide attempts is uncertain. The objective of this study was to evaluate 5-HT2 receptors …
Authors
Meyer JH; Kapur S; Houle S; DaSilva J; Owczarek B; Brown GM; Wilson AA; Kennedy SH
Journal
American Journal of Psychiatry, Vol. 156, No. 7, pp. 1029–1034
Publisher
American Psychiatric Association Publishing
Publication Date
July 1, 1999
DOI
10.1176/ajp.156.7.1029
ISSN
0002-953X