Journal article
Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial
Abstract
INTRODUCTION: Observational evidence suggests physiological benefits and lower mortality with lower chloride solutions; however, 0.9% saline remains the most widely used fluid worldwide. Given uncertainty regarding the association of lower chloride on mortality, it is unlikely that practice will change without direct randomised clinical trial (RCT) evidence. This pilot RCT will investigate the feasibility of a large-scale trial directly …
Authors
Rochwerg B; Millen T; Austin P; Zeller M; D’Aragon F; Jaeschke R; Masse M-H; Mehta S; Lamontagne F; Meade M
Journal
BMJ Open, Vol. 7, No. 7,
Publisher
BMJ
Publication Date
July 2017
DOI
10.1136/bmjopen-2017-017602
ISSN
2044-6055