Journal article
Outcomes for patients with the same disease treated inside and outside of randomized trials: a systematic review and meta-analysis
Abstract
BACKGROUND: It is unclear whether participation in a randomized controlled trial (RCT), irrespective of assigned treatment, is harmful or beneficial to participants. We compared outcomes for patients with the same diagnoses who did ("insiders") and did not ("outsiders") enter RCTs, without regard to the specific therapies received for their respective diagnoses.
METHODS: By searching the MEDLINE (1966-2010), Embase (1980-2010), CENTRAL …
Authors
Fernandes N; Bryant D; Griffith L; El-Rabbany M; Fernandes NM; Kean C; Marsh J; Mathur S; Moyer R; Reade CJ
Journal
Canadian Medical Association Journal, Vol. 186, No. 16, pp. e596–e609
Publisher
Joule
Publication Date
November 4, 2014
DOI
10.1503/cmaj.131693
ISSN
0820-3946