The Tactics of Large Randomized Trials Journal Articles

abstract

• Abstract: Single-center studies and small randomized controlled trials often provide contradictory or inconclusive results. In contrast, large randomized controlled trials are designed to definitively answer a relevant and practice-changing research question. These studies rely on large sample sizes to gain adequate precision of the results and substantial funding to support the research infrastructure necessary to minimize bias. Tactics for successfully completing a large randomized controlled trial are outlined with examples from recent orthopaedic trials.

authors

• Slobogean, Gerard P
• Sprague, Sheila Ann
• Bhandari, Mohit

status

• published 

publication date

• July 18, 2012

has subject area

• 0903 Biomedical Engineering (FoR)
• 1103 Clinical Sciences (FoR)
• Humans (MeSH)
• Multicenter Studies as Topic (MeSH)
• Orthopedic Procedures (MeSH)
• Orthopedics (Science Metrix)
• Patient Dropouts (MeSH)
• Patient Selection (MeSH)
• Randomized Controlled Trials as Topic (MeSH)
• Research Design (MeSH)
• Research Support as Topic (MeSH)
• Sample Size (MeSH)

published in

• Journal of Bone and Joint Surgery. American volume  Journal

keywords

• Humans
• Multicenter Studies as Topic
• Orthopedic Procedures
• Patient Dropouts
• Patient Selection
• Randomized Controlled Trials as Topic
• Research Design
• Research Support as Topic
• Sample Size

Digital Object Identifier (DOI)

• 10.2106/jbjs.l.00189

PubMed ID

• 22810442

start page

• 19

end page

• 23

volume

• 94

issue

• Supplement_1