Journal article
A systematic survey of randomised trials that stopped early for reasons of futility
Abstract
BackgroundRandomised trial protocols may incorporate interim analyses, with the potential to stop the study for futility if early data show insufficient promise of a treatment benefit. Previously, we have shown that this approach will theoretically lead to mis-estimation of the treatment effect. We now wished to ascertain the importance of this phenomenon in practice.MethodsWe reviewed the methods and results in a set of trials that had stopped …
Authors
Walter SD; Han H; Guyatt GH; Bassler D; Bhatnagar N; Gloy V; Schandelmaier S; Briel M
Journal
BMC Medical Research Methodology, Vol. 20, No. 1,
Publisher
Springer Nature
Publication Date
December 2020
DOI
10.1186/s12874-020-0899-1
ISSN
1471-2288