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A systematic survey of randomised trials that...
Journal article

A systematic survey of randomised trials that stopped early for reasons of futility

Abstract

BackgroundRandomised trial protocols may incorporate interim analyses, with the potential to stop the study for futility if early data show insufficient promise of a treatment benefit. Previously, we have shown that this approach will theoretically lead to mis-estimation of the treatment effect. We now wished to ascertain the importance of this phenomenon in practice.MethodsWe reviewed the methods and results in a set of trials that had stopped …

Authors

Walter SD; Han H; Guyatt GH; Bassler D; Bhatnagar N; Gloy V; Schandelmaier S; Briel M

Journal

BMC Medical Research Methodology, Vol. 20, No. 1,

Publisher

Springer Nature

Publication Date

December 2020

DOI

10.1186/s12874-020-0899-1

ISSN

1471-2288