Journal article
Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study
Abstract
BackgroundThe standard definition for protocol adherence is the proportion of all scheduled doses that are delivered. In clinical research, this definition has several limitations when evaluating protocol adherence in trials that study interventions requiring continuous titration.DiscussionBuilding upon a specific case study, we analyzed a recent trial of a continuously titrated intervention to assess the impact of different definitions of …
Authors
Lauzier F; Adhikari NK; Seely A; Koo KKY; Belley-Côté EP; Burns KEA; Cook DJ; D’Aragon F; Rochwerg B; Kho ME
Journal
BMC Medical Research Methodology, Vol. 17, No. 1,
Publisher
Springer Nature
Publication Date
12 2017
DOI
10.1186/s12874-017-0388-3
ISSN
1471-2288