Randomized, controlled clinical trials in sepsis: Has methodological quality improved over time?

Abstract

OBJECTIVE: To systematically evaluate the methodological quality of randomized clinical trials and to determine whether randomized clinical trials of sepsis improved in methodological quality over time. DATA SOURCES: Computerized MEDLINE search of articles published in any language from 1966 to 1998 combined with a manual search of bibliographies of published articles and communication with known experts in the field.

Authors

Graf J; Doig GS; Cook DJ; Vincent J-L; Sibbald WJ

Journal

Critical Care Medicine, Vol. 30, No. 2, pp. 461–472

Publisher

Wolters Kluwer

Publication Date

February 2002

DOI

10.1097/00003246-200202000-00032

ISSN

0090-3493

Associated Experts

Deborah Cook

Professor, Faculty of Health Sciences

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