Can We Learn Anything from Small Trials? Journal Articles

abstract

• In summary, then, we can learn three useful things from small clinical trials. First, we can learn when to challenge conventional but untested therapeutic wisdom. Second, because the patient number in any trial is the number of events, rather than the number of study patients, some small trials are so definitively positive that they are sufficient to identify the best therapy. And third, small trials, even when individually inconclusive, can serve as the basis for convincingly conclusive overviews and meta-analyses that carry, and deserve, greater credibility than a single large trial of similar size to their sum.

authors

• SACKETT, DAVID L
• Cook, Deborah

status

• published 

publication date

• December 1993

has subject area

• Bias (MeSH)
• Confidence Intervals (MeSH)
• Effect Modifier, Epidemiologic (MeSH)
• General Science & Technology (Science Metrix)
• Humans (MeSH)
• Meta-Analysis as Topic (MeSH)
• Randomized Controlled Trials as Topic (MeSH)
• Reproducibility of Results (MeSH)
• Research Design (MeSH)
• Treatment Outcome (MeSH)

published in

• Annals of the New York Academy of Sciences  Journal

keywords

• Bias
• Confidence Intervals
• Effect Modifier, Epidemiologic
• Humans
• Meta-Analysis as Topic
• Randomized Controlled Trials as Topic
• Reproducibility of Results
• Research Design
• Treatment Outcome

Digital Object Identifier (DOI)

• 10.1111/j.1749-6632.1993.tb26331.x

PubMed ID

• 8192301

start page

• 25

end page

• 32

volume

• 703

issue

• 1