Journal article
Beyond the treatment effect: Evaluating the effects of patient preferences in randomised trials
Abstract
The treatments under comparison in a randomised trial should ideally have equal value and acceptability - a position of equipoise - to study participants. However, it is unlikely that true equipoise exists in practice, because at least some participants may have preferences for one treatment or the other, for a variety of reasons. These preferences may be related to study outcomes, and hence affect the estimation of the treatment effect. …
Authors
Walter S; Turner R; Macaskill P; McCaffery K; Irwig L
Journal
Statistical Methods in Medical Research, Vol. 26, No. 1, pp. 489–507
Publisher
SAGE Publications
Publication Date
February 2017
DOI
10.1177/0962280214550516
ISSN
0962-2802