Journal article
Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?
Abstract
The INSIG2 rs7566605 polymorphism was identified for obesity (BMI> or =30 kg/m(2)) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34 studies (n = 74,345), including general population (GP) studies, population-based studies with subjects selected for conditions related to a better health status ('healthy population', HP), and obesity studies (OB). We tested five hypotheses to …
Authors
Heid IM; Huth C; Loos RJF; Kronenberg F; Adamkova V; Anand SS; Ardlie K; Biebermann H; Bjerregaard P; Boeing H
Journal
PLOS Genetics, Vol. 5, No. 10,
Publisher
Public Library of Science (PLoS)
Publication Date
10 2009
DOI
10.1371/journal.pgen.1000694
ISSN
1553-7390