Journal article
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders
Abstract
Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies have yet to identify statistically robust, replicated major effect genes or SNPs. We apply the principle of the SNP ratio test methodology described by O’Dushlaine et al to over 2100 families from the Autism Genome Project (AGP). …
Authors
Anney RJL; Kenny EM; O'Dushlaine C; Yaspan BL; Parkhomenka E; Buxbaum JD; Sutcliffe J; Gill M; Gallagher L; Buxbaum JD
Journal
European Journal of Human Genetics, Vol. 19, No. 10, pp. 1082–1089
Publisher
Springer Nature
Publication Date
10 2011
DOI
10.1038/ejhg.2011.75
ISSN
1018-4813