Protocol for a prospective collaborative overview of all current and planned randomized trials of cholesterol treatment regimens Academic Article uri icon

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abstract

  • The Cholesterol Treatment Trialists' Collaboration aims to provide reliable information about the effects on mortality and morbidity of treatments that modify blood lipid levels for a wide range of patient populations and risk groups. This protocol prospectively defines study eligibility, the main questions to be addressed, and statistical methods to be used. Additionally, by establishing a register of ongoing and planned trials prior to any trial results being known, this systematic overview attempts to avoid the methodologic problems and potential data-dependency of a retrospective project. The collaboration expects to have individual patient data on > 60,000 subjects by the year 2000, including 12,000 women and 20,000 elderly subjects, and should have good power to examine any effects on non-coronary artery disease events. Overall, there should be about 1,900 non-coronary artery disease deaths and > 2,000 total cancer events.

authors

  • DOWNS, JR
  • GOTTO, A
  • CLEARFIELD, M
  • GORDON, D
  • MANOLIO, T
  • GOLDBOURT, U
  • KAPLINSKY, E
  • MOYE, L
  • SACKS, F
  • PFEFFER, M
  • HAWKINS, CM
  • BRAUNWALD, E
  • FRANZOSI, MG
  • MAGGIONI, A
  • TOGNONI, G
  • ROBINS, S
  • RUBINS, H
  • SIMES, J
  • KEECH, A
  • MACMAHON, S
  • TONKIN, A
  • Yusuf, Salim
  • FLATHER, M
  • COLLINS, R
  • KEECH, A
  • ARMITAGE, J
  • BAIGENT, C
  • PETO, R
  • SLEIGHT, P
  • KNATTERUD, G
  • KJEKSHUS, J
  • PEDERSEN, T
  • WILHELMSEN, L
  • ROUSSOUW, J
  • PROBSTFIELD, J
  • COBBE, S
  • MACFARLANE, P
  • SHEPHERD, J

publication date

  • June 1995