Thrombin

subject area of

2 Mechanisms of action of low molecular weight heparins and heparinoids Academic Article
A Barbourin-albumin Fusion Protein that Is Slowly Cleared In Vivo Retains the Ability to Inhibit Platelet Aggregation In Vitro Academic Article
A Graphene-Based Biosensing Platform Based on the Release of DNA Probes and Rolling Circle Amplification Academic Article
A Protease TAMER: a nucleic acid-based anticoagulant Academic Article
A Role for Pericellular Proteoglycan in the Binding of Thrombin or Antithrombin III by the Blood Vessel Endothelium? – The Effects of Proteoglycan-Degrading Enzymes and Glycosaminoglycan-Binding Proteins on 125I-Thrombin Binding by the Rabbit Thoracic Aorta In Vitro Academic Article
A Significant Portion of the Aequorin Luminescent Signal from Stimulated Human and Rabbit Platelets is Due to Exposure of the Aequorin to Calcium in the Suspending Medium Academic Article
A long-lasting, plasmin-activatable thrombin inhibitor aids clot lysis in vitro and does not promote bleeding in vivo Academic Article
A novel approach to thrombin inhibition Academic Article
A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT) Academic Article
A rationale for targeting antithrombotic therapy at the vessel wall: improved antithrombotic effect and decreased risk of bleeding. Academic Article
A review of the oral direct thrombin inhibitor ximelagatran Academic Article
A safety review of topical bovine thrombin-induced generation of antibodies to bovine proteins Academic Article
A single dose of aprotinin prevents platelet hyporeactivity after coronary artery bypass graft surgery. Academic Article
A trypsin-like platelet protease propagates protease-activated receptor-1 cleavage and platelet activation Academic Article
Accumulation of the inositol phosphates in thrombin-stimulated, washed rabbit platelets in the presence of lithium Academic Article
Acquired free protein S deficiency is associated with antiphospholipid antibodies and increased thrombin generation in patients with systemic lupus erythematosus Academic Article
Activation of blood coagulation by plaque rupture: Mechanisms and prevention Academic Article
Activation of factor V during intrinsic and extrinsic coagulation. Inhibition by heparin, hirudin and d-Phe-Pro-Arg-Ch2Cl Academic Article
Activation of factor X and prothrombin in antithrombin-III depleted plasma: The effects of heparin Academic Article
Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells Academic Article
Acute coronary syndromes: a focus on thrombin. Academic Article
Acute in vitro effects of ethanol on responses of platelets from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits. Academic Article
Adjunctive Use of Direct Thrombin Inhibitors in Patients Receiving Fibrinolytic Therapy for Acute Myocardial Infarction Academic Article
Adsorption of thrombin from buffer and modified plasma to polystyrene resins containing sulphonate and sulphamide arginyl methyl ester groups Academic Article
Advances in the management of venous thromboembolism. Academic Article
Affinity Analysis of a Protein−Aptamer Complex Using Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures Academic Article
Age-related changes in factor VII proteolysisin vivo Academic Article
Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor Academic Article
Alpha-2-macroglobulin is an important progressive inhibitor of thrombin in neonatal and infant plasma. Academic Article
Altered inactivation of trinitrophenylated thrombin by antithrombin iii in the presence of heparin Academic Article
Altering Heparin Cofactor II at VAL439 (P6) either Impairs Inhibition of Thrombin or Confers Elastase Resistance Academic Article
Amino acid substitutions of the P2 residue of human antithrombin that either enhance or impair function Academic Article
An Approach to Assigning In Vitro Potency to Unfractionated and Low Molecular Weight Heparins Based on the Inhibition of Prothrombin Activation and Catalysis of Thrombin Inhibition Academic Article
An Overview of the Heparin-Induced Thrombocytopenia Syndrome Academic Article
An acquired factor V inhibitor associated with defective factor V function, storage and binding to multimerin 1 Academic Article
An anticoagulant dermatan sulfate proteoglycan circulates in the pregnant woman and her fetus. Academic Article
An overview of the mechanism of action of antithrombin and its inherited deficiency states. Academic Article
Analysis of Inhibition Rate Enhancement by Covalent Linkage of Antithrombin to Heparin as a Potential Predictor of Reaction Mechanism Academic Article
Another oral thrombin inhibitor for stroke prevention in atrial fibrillation? Academic Article
Anticoagulant Effects of Heparin in Neonatal Plasma' Academic Article
Anticoagulant and Antithrombin Effects of Intimatan, a Heparin Cofactor II Agonist Academic Article
Anticoagulants in heart disease: current status and perspectives Academic Article
Antithrombin III Sudbury: An Ala384 → pro mutation with abnormal thrombin-binding activity and thrombotic diathesis Academic Article
Antithrombin III deficiency in neonatal respiratory distress syndrome Academic Article
Antithrombin III-beta associates more readily than antithrombin III-alpha with uninjured and de-endothelialized aortic wall in vitro and in vivo. Academic Article
Antithrombin-Heparin Covalent Complex Academic Article
Antithrombin-III-Hamilton, Ala 382 to Thr: an antithrombin-III variant that acts as a substrate but not an inhibitor of alpha-thrombin and factor Xa. Academic Article
Antithrombin-III-Hamilton: a gene with a point mutation (guanine to adenine) in codon 382 causing impaired serine protease reactivity. Academic Article
Antithrombin-III-Stockholm: a codon 392 (Gly----Asp) mutation with normal heparin binding and impaired serine protease reactivity. Academic Article
Antithrombotic Properties of Heparin in a Neonatal Piglet Model of Thrombin-Induced Thrombosis Academic Article
Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention Academic Article
Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein Academic Article
Atorvastatin Delays Murine Platelet Activation In Vivo Even in the Absence of Endothelial NO Synthase Academic Article
Batroxobin Binds Fibrin with Higher Affinity and Promotes Clot Expansion to a Greater Extent than Thrombin Academic Article
Benefit of Selective Factor Inhibition Academic Article
Beyond Unfractionated Heparin and Warfarin Academic Article
Binding of Aggregated Immunoglobulins to the Human Platelet Fc Receptors: A Mechanism of Platelet to Platelet Bridging Academic Article
Binding of Thrombin to the G-protein-linked Receptor, and Not to Glycoprotein Ib, Precedes Thrombin-mediated Platelet Activation Academic Article
Biologic rationale for the therapeutic role of specific antithrombins Academic Article
Biological Action of Colorless and Yellow Solutions of Gold Sodium Thiomalate on Thrombin Activity and the Mixed Lymphocyte Reaction Academic Article
Bioregulatory roles for fibrin(ogen) on blood coagulation Academic Article
Bivalent Binding to γA/γ′-Fibrin Engages Both Exosites of Thrombin and Protects It from Inhibition by the Antithrombin-Heparin Complex Academic Article
Bivalirudin, thrombin and platelets: clinical implications and future directions. Academic Article
Blood tests for the diagnosis of venous and arterial thrombosis. Academic Article
Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus Academic Article
By Increasing the Affinity of Heparin for Fibrin, Zn2+ Promotes the Formation of a Ternary Heparin–Thrombin–Fibrin Complex That Protects Thrombin from Inhibition by Antithrombin Academic Article
Cardiopulmonary Bypass Pumps and Thrombin Generation Academic Article
Catalysis of Thrombin Inhibition Provides an Index for Estimating the Antithrombotic Potential of Glycosaminoglycans in Rabbits Academic Article
Challenges with heparin-based anticoagulation during cardiopulmonary bypass in children: Impact of low antithrombin activity Academic Article
Changes in the platelet phosphoinositides during the first minute after stimulation of washed rabbit platelets with thrombin Academic Article
Characterization of the C-terminal Domain of a Potassium Channel fromStreptomyces lividans(KcsA) Academic Article
Chromatography of heparin on Sepharose–lysine: molecular size fractionation and its relevance to thrombin and antithrombin III binding Academic Article
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. Academic Article
Coagulation Assays Academic Article
Coagulation factor XIII and markers of thrombin generation and fibrinolysis in patients with inflammatory bowel disease Academic Article
Comment: Treatment of Heparin-Induced Thrombocytopenia Academic Article
Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development Academic Article
Comparative behavior of thrombin and an inactive derivative, FPR-thrombin, toward the rabbit vascular endothelium. Heparin liberates FPR-thrombin from the endothelium in vivo. Academic Article
Comparative effects of heparin and LMW heparin on hemostasis Conference Paper
Comparative metabolism and distribution of rabbit heparin cofactor II and rabbit antithrombin in rabbits Academic Article
Comparison of Heparin- and Dermatan Sulfate-mediated Catalysis of Thrombin Inactivation by Heparin Cofactor II Academic Article
Comparison of mammalian and bacterial expression library screening to detect recombinant alpha-1 proteinase inhibitor variants with enhanced thrombin inhibitory capacity☆ Academic Article
Comparison of the Oral Direct Thrombin Inhibitor Ximelagatran With Enoxaparin as Prophylaxis Against Venous Thromboembolism After Total Knee Replacement Academic Article
Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA Academic Article
Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the organization to assess strategies in acute ischemic syndromes (OASIS)-5 trial Academic Article
Comparison of the effects of heparin and hirudin on thrombin binding to the normal and the de-endothelialized rabbit aorta in vitro. Academic Article
Comparison of three-factor and four-factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers Academic Article
Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study Academic Article
Conformational Changes in Thrombin When Complexed by Serpins Academic Article
Control Mechanisms in Thrombin Generation Academic Article
Coordinate Activation of Human Platelet Protease-activated Receptor-1 and -4 in Response to Subnanomolar α-Thrombin Academic Article
Covalent antithrombin-heparin effect on thrombin-thrombomodulin and activated protein C reaction with factor V/Va Academic Article
Current anticoagulant therapy—unmet clinical needs Conference Paper
Dabigatran Etexilate Academic Article
Dabigatran Etexilate: Future Directions in Anticoagulant Treatment Academic Article
Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function Academic Article
Dabigatran attenuates thrombin generation to a lesser extent than warfarin: could this explain their differential effects on intracranial hemorrhage and myocardial infarction? Academic Article
Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve‐Induced Thrombin Generation Academic Article
Dabigatran monitoring made simple? Academic Article
Decreased Concentrations of Heparinoids Are Required to Inhibit Thrombin Generation in Plasma from Newborns and Children Compared to Plasma from Adults due to Reduced Thrombin Potential Academic Article
Decreased Thrombin Activity of Fibrin Clots Prepared in Cord Plasma Compared with Adult Plasma Academic Article
Deendothelialization in vivo initiates a thrombogenic reaction at the rabbit aorta surface. Correlation of uptake of fibrinogen and antithrombin III with thrombin generation by the exposed subendothelium. Academic Article
Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis Academic Article
Deletion mutagenesis of heparin cofactor II: defining the minimum size of a thrombin inhibiting serpin Academic Article
Detection of human fetal fibrinogen in umbilical cord plasma by parallel assays of immunoreactive and thrombin-clottable protein. Academic Article
Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency. Academic Article
Developmental haemostasis Academic Article
Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet-mediated events during thrombus formation Academic Article
Differences between platelet phosphoinositide metabolism stimulated by thrombin or SFLLRN are not accounted for by interaction of thrombin with glycoprotein Ib Academic Article
Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation Academic Article
Direct Factor Xa and direct thrombin inhibitors: a clinical trial update. Academic Article
Direct Thrombin Inhibitors in Acute Coronary Syndromes Academic Article
Direct Thrombin Inhibitors in Cardiac Disease Academic Article
Direct thrombin inhibitors Academic Article
Direct thrombin inhibitors in acute coronary syndromes Academic Article
Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention Academic Article
Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data Academic Article
Displacement of fibrin-bound thrombin by r-hirudin precludes the use of 131I-r-hirudin for detecting pulmonary emboli in the rabbit. Academic Article
Disseminated intravascular coagulation. Experimental models of microangiopathic haemolytic anaemia. Academic Article
Do coagulation screening tests detect increased generation of thrombin and plasmin in sick newborn infants? Academic Article
Does an enzyme other than thrombin contribute to unexpected changes in the levels of the different forms of thrombin activatable fibrinolysis inhibitor in patients with hemophilia A, hemophilia B and von Willebrand disease? Academic Article
EFFECT OF SERA ON THROMBIN ACTIVATION RATE CONSTANTS: A ONE-STAGE ASSAY OF THE EXTRINSIC SYSTEM Academic Article
Early Intraplatelet Signaling Enhances the Release of Human Platelet PAR-1 and -4 Amino-Terminal Peptides in Response to Thrombin† Academic Article
Effect of Covalent Serpin–Heparinoid Complexes on Plasma Thrombin Generation on Fetal Distal Lung Epithelium Academic Article
Effect of Heparin Loading During Congenital Heart Operation on Thrombin Generation and Blood Loss Academic Article
Effect of Nonspecific Binding to Plasma Proteins on the Antithrombin Activities of Unfractionated Heparin, Low-Molecular-Weight Heparin, and Dermatan Sulfate Academic Article
Effect of a novel covalent antithrombin-heparin complex on thrombin generation on fetal distal lung epithelium. Academic Article
Effect of disease and chemotherapy on hemostasis in children with acute lymphoid leukemia. Academic Article
Effect of gaboon viper (Bitis gabonica) venom on blood coagulation, platelets, and the fibrinolytic enzyme system Academic Article
Effect of heparins on thrombin generation in hemophilic plasma supplemented with FVIII, FVIIa, or FEIBA. Academic Article
Effect of substrate and fibrin polymerization inhibitor on determination of plasma thrombin generation in vitro Academic Article
Effects of Dermatan Sulfate and Heparin on Inhibition of Thrombus Growth in Vivo Academic Article
Effects of Intermittent Pneumatic Calf Compression On Postoperative Thrombin and Plasmin Activity Academic Article
Effects of heparin fractions of different affinities to antithrombin III and thrombin on the inactivation of thrombin and factor Xa by antithrombin III Academic Article
Effects of sulfated polysaccharides on inhibition of thrombus formation initiated by different stimuli. Academic Article
Effects on Thrombin Generation of Single Injections of Hirulog™ in Patients with Calf Vein Thrombosis Academic Article
Elevated Fibrinopeptide A and B Levels during Thrombolytic Therapy: Real or Artefactual? Academic Article
Enhanced binding of fibrinogen by the subendothelium after treatment of the rabbit aorta with thrombin. Academic Article
Evaluation of DNA aptamers directed to thrombin as potential thrombus imaging agents Academic Article
Evidence That Both Exosites on Thrombin Participate in Its High Affinity Interaction with Fibrin Academic Article
Evidence for Allosteric Linkage between Exosites 1 and 2 of Thrombin Academic Article
Evidence for thrombin binding to dermatan sulphate sites in the rabbit aorta subendothelium in vitro Academic Article
Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin–Thrombomodulin Complex Academic Article
Exosites 1 and 2 Are Essential for Protection of Fibrin-bound Thrombin from Heparin-catalyzed Inhibition by Antithrombin and Heparin Cofactor II Academic Article
Expression in a cell-free system of normal and variant forms of human antithrombin III. Ability to bind heparin and react with alpha-thrombin. Academic Article
Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity Academic Article
Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood Academic Article
Extracellular Histones Increase Tissue Factor Activity and Enhance Thrombin Generation by Human Blood Monocytes Academic Article
Factor Xa and thrombin as targets for new oral anticoagulants Academic Article
Factor Xa or thrombin: Is thrombin a better target? Conference Paper
Familial thrombophilia and the prothrombin 20210A mutation Academic Article
Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists Academic Article
Fate of Thrombin and Thrombin-Antithrombin-III Complex Adsorbed to a Heparinized Biomaterial: Analysis of the Enzyme-Inhibitor Complexes Displaced by Plasma Academic Article
Fibrin moderates the catalytic action of heparin but not that of dermatan sulfate on thrombin inhibition in human plasma. Academic Article
Fibrinogenolysis and thrombin generation after reduced dose bolus or conventional rt-PA for pulmonary embolism. The Coagulation Project Investigators of the Bolus Alteplase Pulmonary Embolism Group. Academic Article
Fibrinolytic properties of lysine-derivatized polyethylene in contact with flowing whole blood (Chandler loop model) Academic Article
Fluorous Analogue of Chloramine-T: Preparation, X-ray Structure Determination, and Use as an Oxidant for Radioiodination and s-Tetrazine Synthesis Academic Article
Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT) – Bridging the River Coumarin Academic Article
Free calcium response to adrenaline in platelets of normal and hypertensive (untreated and treated) subjects. Academic Article
Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II: P1 Arg Is Required for Maximal Thrombin Inhibition Academic Article
Further Studies on the Mechanisms for the Antithrombotic Effects of Sulfated Polysaccharides in Rabbits Academic Article
Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition Academic Article
G-Protein–Coupled Receptors as Signaling Targets for Antiplatelet Therapy Academic Article
Global haemostasis and point of care testing Academic Article
Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors Academic Article
HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase Academic Article
HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions Academic Article
HEPARIN-INDUCED THROMBOCYTOPENIA: A Ten-Year Retrospective Academic Article
HUMAN PLATELET THROMBIN RECEPTORS Academic Article
Heparan sulfate and dermatan sulfate inhibit the generation of thrombin activity in plasma by complementary pathways. Academic Article
Heparan sulfate: Antithrombotic or not? Academic Article
Heparin Cofactor II and Other Endogenous Factors in the Mediation of the Antithrombotic and Anticoagulant Effects of Heparin and Dermatan Sulfate Academic Article
Heparin and Low Molecular Weight Heparins Inhibit Prothrombinase Formation but not its Activity in Plasma Academic Article
Heparin inhibits thrombin binding to rabbit thoracic aorta endothelium. Academic Article
Heparin sensitivity and resistance in the neonate: An explanation Academic Article
Heparin with low affinity to antithrombin III inhibits the activation of prothrombin in normal plasma Academic Article
Heparin-induced thrombocytopenia - therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhibit formation of platelet factor 4-heparin complexes Academic Article
Heparin-induced thrombocytopenia in intensive care patients Academic Article
Heparin-induced thrombocytopenia: pathogenesis and management Academic Article
Heparinless cardiopulmonary bypass revisited: A newer strategy to avoid heparin-related bleeding using dermatan sulfate Academic Article
Hirulog in the Treatment of Unstable Angina Academic Article
Histidine-rich Glycoprotein Binds Fibrin(ogen) with High Affinity and Competes with Thrombin for Binding to the γ′-Chain Academic Article
Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway Academic Article
Human platelets contain forms of factor V in disulfide-linkage with multimerin Academic Article
Human tissue-type plasminogen activator releases fibrinopeptides A and B from fibrinogen. Academic Article
Hypercoagulability after trauma: Hemostatic changes and relationship to venous thromboembolism Academic Article
IMPACT OF MUTATIONS AT THE P4 AND P5 POSITIONS ON THE REACTION OF ANTITHROMBIN WITH THROMBIN AND ELASTASE Academic Article
INHIBITION OF THROMBIN BY HIRUDIN GENETICALLY FUSED TO WILD-TYPE OR MUTANT ANTITHROMBIN Academic Article
Identification of Dp71 Isoforms in the Platelet Membrane Cytoskeleton Academic Article
Identification of the MMRN1 Binding Region within the C2 Domain of Human Factor V Academic Article
Immune Responses Associated With Perioperative Exposure and Reexposure to Topical Bovine Thrombin Do Not Impair Hemostasis Academic Article
Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients Academic Article
In Vitro and in Vivo Functions of Thrombin-Treated Platelets \textbar Request PDF Academic Article
In VivoClearance of Ternary Complexes of Vitronectin-Thrombin-Antithrombin Is Mediated by Hepatic Heparan Sulfate Proteoglycans Academic Article
In VivoFormation of Protein Based Aqueous Microcompartments Academic Article
In the Presence of Phospholipids, Glycosaminoglycans Potentiate Factor Xa-Mediated Protein C Activation by Modulating Factor Xa Activity† Academic Article
In vivo behaviour of some antithrombin III-protease complexes. Academic Article
Inactivation of thrombin by antithrombin III on a heparinized biomaterial Academic Article
Increased sulphation improves the anticoagulant activities of heparan sulphate and dermatan sulphate Academic Article
Increased thrombin generation and activity in patients with systemic lupus erythematosus and anticardiolipin antibodies: evidence for a prothrombotic state. Academic Article
Influence of Mechanical Stretch on Thrombin Regulation by Fetal Mixed Lung Cells Academic Article
Influence of activated factor VII concentrates on thrombin generation in full-term and preterm neonates Academic Article
Influence of exogenous factor VIIa on thrombin generation in cord plasma of full-term and pre-term newborns Academic Article
Influenza virus H1N1 activates platelets through Fc RIIA signaling and thrombin generation Academic Article
Inhibition of Fibrin-Bound Thrombin by a Covalent Antithrombin-Heparin Complex Academic Article
Inhibition of Thrombin by Antithrombin III and Heparin Cofactor II In Vivo Academic Article
Inhibition of Thrombin-Neutralizing Activity of Antithrombin III by Steroid Hormones Academic Article
Inhibition of factor X and factor V activation by dermatan sulfate and a pentasaccharide with high affinity for antithrombin III in human plasma Academic Article
Inhibition of factor X, factor V and prothrombin activation by the bis(lactobionic acid amide) LW10082 Academic Article
Inhibition of platelet-dependent prothrombinase activity and thrombin generation by glycoprotein IIb/IIIa receptor-directed antagonists: potential contributing mechanism of benefit in acute coronary syndromes. Academic Article
Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors ofα-thrombin Academic Article
Inhibition of thrombin by antithrombin III in the presence of certain glycosaminoglycans found in the mammalian aorta Academic Article
Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome Academic Article
Interactions of thermally denatured fibrinogen on polyethylene with plasma proteins and platelets Academic Article
Intravascular Haemolysis with Experimentally Produced Vascular Thrombi Academic Article
Investigation of the Anticoagulant Mechanisms of a Covalent Antithrombin-Heparin Complex Academic Article
Investigation of the Mechanism of False Positive125I-Labelled Fibrinogen Scans Academic Article
Kinetic Analysis of a Unique Direct Prothrombinase, fgl2, and Identification of a Serine Residue Critical for the Prothrombinase Activity Academic Article
Lack of Relationship Between Enhanced Bleeding Induced by Heparin and Other Sulfated Polysaccharides and Enhanced Catalysis of Thrombin Inhibition Academic Article
Localization of the Thrombin-binding Domain on Prothrombin Fragment 2 Academic Article
Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function Academic Article
Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential Academic Article
MMP9 modulates tight junction integrity and cell viability in human airway epithelia Academic Article
Management of Patients with Acute Coronary Syndromes Academic Article
Mast Cell–Derived Exosomes Activate Endothelial Cells to Secrete Plasminogen Activator Inhibitor Type 1 Academic Article
Mechanism of inhibition of the prothrombinase complex by a covalent antithrombin-heparin complex Academic Article
Mechanisms Responsible for Catalysis of the Inhibition of Factor Xa or Thrombin by Antithrombin Using a Covalent Antithrombin-Heparin Complex Academic Article
Mechanisms for Inhibition of the Generation of Thrombin Activity by Sulfated Polysaccharides Academic Article
Mechanisms for the anticoagulant effect of heparin and related polysaccharides. Academic Article
Mechanisms of Action of Heparin: Applications to the Development of Derivatives of Heparin and Heparinoids with Antithrombotic Properties Academic Article
Meeting the Unmet Needs in Anticoagulant Therapy Academic Article
Microheterogeneity of antithrombin III: effect of single amino acid substitutions and relationship with functional abnormalities. Academic Article
Modes and consequences of thrombin's interaction with fibrin Academic Article
Modulation of intrinsic prothrombin activation by fibrinogen and fibrin I. Academic Article
Modulation of the Enzymatic Activity of α-Thrombin by Polyanions: Consequences on Intrinsic Activation of Factor V and Factor VIII Academic Article
Molecular Basis for the Susceptibility of Fibrin-bound Thrombin to Inactivation by Heparin Cofactor II in the Presence of Dermatan Sulfate but Not Heparin Academic Article
Molecular basis for the resistance of fibrin-bound thrombin to inactivation by heparin/serpin complexes. Academic Article
Molecular basis of inherited human antithrombin deficiency. Academic Article
Molecular cloning and expression of rabbit antithrombin III. Academic Article
Morphological analysis of microparticle generation in heparin-induced thrombocytopenia. Academic Article
Multicentric warfarin-induced skin necrosis complicating heparin-induced thrombocytopenia Academic Article
Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation Academic Article
NMR Structures Reveal How Oxidation Inactivates Thrombomodulin† Academic Article
Neutralization of Enoxaparine-lnduced Bleeding by Protamine Sulfate Academic Article
Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms Academic Article
New Anticoagulant Strategies Academic Article
New Anticoagulant Therapy Academic Article
New Anticoagulants Academic Article
New Antithrombotic Drugs Academic Article
New Antithrombotics Academic Article
New anticoagulant strategies. Academic Article
New anticoagulants Conference Paper
New anticoagulants for the prevention and treatment of venous thromboembolism Academic Article
New anticoagulants for venous thromboembolic disease Academic Article
New aspects on treatment modalities for thromboembolic episodes Academic Article
New developments in parenteral anticoagulation for arterial and venous thromboembolism Academic Article
New oral anticoagulants in atrial fibrillation Academic Article
New oral anticoagulants in development Academic Article
New oral anticoagulants: which one should my patient use? Academic Article
New pharmacotherapy for stroke prevention in atrial fibrillation: Update 2010 Academic Article
Novel Oral Factor Xa and Thrombin Inhibitors in the Management of Thromboembolism Academic Article
Novel anticoagulant agents: introduction Academic Article
Novel paediatric anticoagulants: a review of the current literature Academic Article
On the interaction of rabbit antithrombin III with the luminal surface of the normal and deendothelialized rabbit thoracic aorta in vitro. Academic Article
Only high levels of dabigatran attenuate catheter thrombosis in vitro and in rabbits Academic Article
Orally Active Direct Thrombin Inhibitors Academic Article
Organ Distribution of Fibrin in Disseminated Intravascular Coagulation Academic Article
Overexpression of the 78-kDa Glucose-regulated Protein/Immunoglobulin-binding Protein (GRP78/BiP) Inhibits Tissue Factor Procoagulant Activity Academic Article
Parenteral Anticoagulants Academic Article
Pathobiologic features and prevention of thrombotic complications associated with prosthetic heart valves: Fundamental principles and the contribution of platelets and thrombin Academic Article
Peptide modified gold-coated polyurethanes as thrombin scavenging surfaces. Academic Article
Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin Academic Article
Pharmacology and Clinical Potential of Direct Thrombin Inhibitors Academic Article
Phosphatidylinositol 4,5-bisphosphate is selectively retained by platelet-fibrin clots formed by thrombin Academic Article
Plasma Anticoagulant Mechanisms of Heparin, Heparan Sulfate, and Dermatan Sulfate Academic Article
Plasma Thrombin Neutralization Assay: Pharmacokinetic Applications Academic Article
Plasmin accelerates platelet-dependent prothrombinase formation without activating the platelets Academic Article
Platelet factor V New York: a defect in factor V distinct from that in factor V Quebec resulting in impaired prothrombinase generation. Academic Article
Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non-valvular atrial fibrillation from the RE-LY trial Academic Article
Predictors of clinical outcome in patients with heparin-induced thrombocytopenia treated with direct thrombin inhibition Academic Article
Prevention of Thrombus Growth by Antithrombin III-Dependent and Two Direct Thrombin Inhibitors in Rabbits: Implications for Antithrombotic Therapy Academic Article
Prevention of activation of blood coagulation during acute coronary ischemic syndromes beyond aspirin and heparin Academic Article
Prevention of thrombus formation and growth by antithrombin III and heparin cofactor II-dependent thrombin inhibitors: Importance of heparin cofactor II Academic Article
Prognostic utility and characterization of cell-free DNA in patients with severe sepsis Academic Article
Prolonged Antithrombin Activity of Low-Molecular-Weight Heparins Academic Article
Prolonged in vivo anticoagulant activity of a hirudin–albumin fusion protein secreted from Pichia pastoris Academic Article
Protease activated receptors 1 and 4 govern the responses of human platelets to thrombin Academic Article
Quality Control Certification of RNA Aptamer-Based Detection Academic Article
RESOLUTION OF ACUTE MASSIVE PULMONARY EMBOLISM AFTER PULMONARY ARTERIAL INFUSION OF STREPTOKINASE Academic Article
Radiolabeled r-Hirudin as a Measure of Thrombin Activity at, or within, the Rabbit Aorta Wall In Vitro and In Vivo Academic Article
Reduced Plasminogen Binding and Delayed Activation Render γ′-Fibrin More Resistant to Lysis than γA-Fibrin Academic Article
Reduction of thrombus size in murine models of thrombosis following administration of recombinant α1-proteinase inhibitor mutant proteins Academic Article
Reversing anticoagulants both old and new. Academic Article
Review: Laboratory markers quantifying prothrombin activation and actions of thrombin in venous and arterial thrombosis do not accurately assess disease severity or the effectiveness of treatment Academic Article
Safety and Efficacy of Thrombin-JMI: A Multidisciplinary Expert Group Consensus Academic Article
Secondary Prevention of Venous Thromboembolism with the Oral Direct Thrombin Inhibitor Ximelagatran Academic Article
Selective and Sustained Inhibition of Surface-bound Thrombin Activity by Intimatan/Heparin Cofactor II and Its Relevance to Assessing Systemic Anticoagulation In Vivo, Ex Vivo and In Vitro Academic Article
Serum Lipid Profile Determines Platelet Reactivity to Native and Modified LDL-Cholesterol in Humans Academic Article
Serum-induced platelet procoagulant activity: An assay for the characterization of prothrombotic disorders Academic Article
Shortening of the Bleeding Time in Rabbits by Hydrocortisone Caused by Inhibition of Prostacyclin Generation by the Vessel Wall Academic Article
Site-directed mutagenesis of the P2 residue of human antithrombin Academic Article
State-of-the-Art-Review : Statins Induce Hypothrombotic States? Academic Article
Statins and Thrombin Academic Article
Streptokinase and rt-PA activate platelets by a different way: implications on the rethrombosis rate after their administration in myocardial infarction. Academic Article
Structural Effects of a Covalent Linkage Between Antithrombin and Heparin: Covalent N-Terminus Attachment of Heparin Enhances the Maintenance of Antithrombin's Activated State Academic Article
Structure-Switching Signaling Aptamers Academic Article
Studies investigating platelet aggregation and release initiated by sera from patients with thrombotic thrombocytopenic purpura. Academic Article
Studies on the coagulant enzyme fromAgkistrodon rhodostomavenom. Isolation and some properties of the enzyme Academic Article
Surface modification with PEG and hirudin for protein resistance and thrombin neutralization in blood contact Academic Article
Synthesis and radioiodination of a stannyl oligodeoxyribonucleotide Academic Article
TAFIa (CPU) is generatedin vivoat levels that can substantially affect fibrinolysis in chimpanzees in response to thrombin generation Academic Article
Targeting Tumor Vasculature With an Oncolytic Virus Academic Article
Temperature-dependence of LDL binding and activation of human platelets Academic Article
Thalidomide-prednisone maintenance following autologous stem cell transplant for Multiple Myeloma: effect on thrombin generation and procoagulant markers in NCIC CTG MY.10 Academic Article
The Additive Effect of Low Molecular Weight Heparins on Thrombin Inhibition by Dermatan Sulfate Academic Article
The Antithrombotic Properties of Human Prothrombin Fragment 1.2 in Mice Academic Article
The Asp272–Glu282Region of Platelet Glycoprotein Ibα Interacts with the Heparin-binding Site of α-Thrombin and Protects the Enzyme from the Heparin-catalyzed Inhibition by Antithrombin III Academic Article
The Binding of Unfractionated Heparin and Low Molecular Weight Heparin to Thrombin-Activated Human Endothelial Cells Academic Article
The Clearance of Thrombin-antithrombin and Related Serpin-enzyme Complexes from the Circulation: Role of Various Hepatocyte Receptors Academic Article
The Cleaved Peptide of PAR1 Results in a Redistribution of the Platelet Surface GPIb-IX-V Complex to the Surface-Connected Canalicular System Academic Article
The Coagulation System in Humans Academic Article
The Effect of Antithrombin III-Independent Thrombin Inhibitors and Heparin on Fibrin Accretion onto Fibrin-Coated Polyethylene \textbar Request PDF Academic Article
The Effect of Heparin Adsorbed on Sepharose-Lysine on the Inactivation of Thrombin by Anti-Thrombin III Academic Article
The Effect of Thrombin on Platelet Accumulation on the Vessel Wall - Influence of Heparin and Aspirin Academic Article
The Effects of Heparin and Annexin V on Fibrin Accretion after Injury in the Jugular Veins of Rabbits Academic Article
The Effects of Hormone Replacement Therapy on Thrombin Generation, Fibrinolysis Inhibition, and Resistance to Activated Protein C Academic Article
The Effects of Steroids on Coagulation Dysfunction Induced by Cardiopulmonary Bypass: A Steroids in Cardiac Surgery (SIRS) Trial Substudy Academic Article
The King is Dead (Warfarin): Direct Thrombin and Factor Xa Inhibitors: The Next Diadochian War? Academic Article
The Molecular Pathology of Inherited Human Antithrombin III Deficiency Academic Article
The Oral Thrombin Inhibitor Dabigatran: Strengths and Weaknesses Academic Article
The Pathogenesis of Venous Limb Gangrene Associated with Heparin-Induced Thrombocytopenia Academic Article
The Pathophysiology of Heparin-Induced Thrombocytopenia Academic Article
The Transferable Tail: Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α1-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition† Academic Article
The absence of `minor' risk factors for recurrent venous thromboembolism: a systematic review of negative predictive values and negative likelihood ratios Academic Article
The adrenaline -α2-adrenoceptor-mediated vasoconstrictor axis Academic Article
The affinity of human, rabbit and bovine thrombins for sepharose-lysine and other conjugates Academic Article
The appended tail region of heparin cofactor II and additional reactive centre loop mutations combine to increase the reactivity and specificity of α1-proteinase inhibitor M358R for thrombin Academic Article
The beginning of the end of warfarin? Academic Article
The benefit-to-risk profile of melagatran is superior to that of hirudin in a rabbit arterial thrombosis prevention and bleeding model Academic Article
The blood platelet as a model for regulating blood coagulation on cell surfaces and its consequences. Academic Article
The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal-based and cell-based models Academic Article
The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand Academic Article
The decrease in phosphatidylinositol 4,5-bisphosphate in ADP-stimulated washed rabbit platelets is not primarily due to phospholipase C activation Academic Article
The direct thrombin inhibitor hirudin Academic Article
The effect of thrombin inhibitors on tissue plasminogen activator induced thrombolysis in a rat model. Academic Article
The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces Academic Article
The evolving role of direct thrombin inhibitors in acute coronary syndromes. Academic Article
The hypercoagulable state in cancer patients Academic Article
The hypersensitivity to thrombin of platelets from diabetic rats is not due to increased thrombin binding Academic Article
The impact of the endothelial protein C receptor on thrombin generation and clot lysis Academic Article
The importance of thrombin inhibition for the expression of the anticoagulant activities of heparin, dermatan sulphate, low molecular weight heparin and pentosan polysulphate Academic Article
The inactivation of thrombin and plasmin by antithrombin III in the presence of Sepharose-heparin Academic Article
The influence of heparin, NaCl and CaCl2 on the rate of the thrombin-antithrombin III reaction Academic Article
The inhibition by heparin of the intrinsic pathway activation of factor X in the absence of antithrombin-III Academic Article
The inhibition of the anticoagulant activity of heparin by platelets, brain phospholipids, and tissue factor Academic Article
The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin Academic Article
The inhibitory effects of exogenous arachidonic acid on rabbit platelet aggregation and the release reaction. Academic Article
The plasma concentration of activated protein C appears normal in patients with haemophilia Academic Article
The plasma proteases, thrombin and plasmin, degrade the proteoglycan of rabbit aorta segments in vitro: an integrated ultrastructural and biochemical study. Academic Article
The presence of plasma proteins facilitates the uptake of 125I-thrombin by the rabbit thoracic aorta endothelium Academic Article
The proteolytic action of Arvin on human fibrinogen Academic Article
The relative importance of thrombin inhibition and factor Xa inhibition to the antithrombotic effects of heparin. Academic Article
The status of new anticoagulants Academic Article
The thrombogenicity of prothrombin complex concentrates: I. The relationship between characteristics and thrombogenicity in rabbits Academic Article
TheN-terminal domain of antithrombin-III is essential for heparin binding and complex-formation with, but not cleavage by,α-thrombin Academic Article
Think of HIT Academic Article
Thrombin Binds to Soluble Fibrin Degradation Products Where it Is Protected From Inhibition by Heparin-Antithrombin but Susceptible to Inactivation by Antithrombin-Independent Inhibitors Academic Article
Thrombin Generation Academic Article
Thrombin Generation and Presence of Thrombin Receptor in Ovarian Follicles1 Academic Article
Thrombin Generation during Cardiac Surgery: Is Heparin the Ideal Anticoagulant? Academic Article
Thrombin Inhibition Is Impaired in Plasma of Sick Neonates Academic Article
Thrombin Inhibition by Hirudin: How Hirudin Inhibits Thrombin Academic Article
Thrombin Regulation in Mother and Fetus During Pregnancy Academic Article
Thrombin activation rate constant: One-stage chromogenic assay for the extrinsic system Academic Article
Thrombin and Antithrombotics Academic Article
Thrombin binding to platelets and their activation in plasma Academic Article
Thrombin binding to platelets from hypercholesterolaemic rats Academic Article
Thrombin generation after the abrupt cessation of intravenous unfractionated heparin among patients with acute coronary syndromes Academic Article
Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin. Academic Article
Thrombin generation in patients undergoing carotid endarterectomy: Implications in acute vessel wall closure and antithrombotic therapy Academic Article
Thrombin generation, ProC(®)Global, prothrombin time and activated partial thromboplastin time in thawed plasma stored for seven days and after methylene blue/light pathogen inactivation. Academic Article
Thrombin generationin vitroin the presence of by-passing agents in siblings with severe haemophilia A Academic Article
Thrombin structure and function Academic Article
Thrombin-induced inositol phosphate production by platelets from rats with diet-induced or genetically determined hypercholesterolemia. Academic Article
Thrombin-induced inositol trisphosphate production by rabbit platelets is inhibited by ethanol Academic Article
Thrombocytopenia in Preeclampsia and Eclampsia Academic Article
Thrombocytopenia in septicemia: the role of disseminated intravascular coagulation. Academic Article
Thromboepidemiology: Identifying patients with heritable risk for thrombin-mediated thromboembolic events Academic Article
Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome Academic Article
Tissue factor microparticles and haemophilia Academic Article
U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets. Academic Article
Uncontrolled PGI2 production by whole vessel wall segments due to thrombin generation and its prevention by heparin Academic Article
Understanding Thrombin and Hemostasis Academic Article
Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa Academic Article
Uptake and Catabolism of 125l-Thrombin by the Rabbit Thoracic Aorta In Vitro: Permeability of the Endothelium, Intima-Media and Adventitial Layers Academic Article
Urokinase has direct catalytic activity against fibrinogen and renders it less clottable by thrombin. Academic Article
Use of Hirulog in the prevention of venous thrombosis after major hip or knee surgery. Academic Article
Using direct oral anticoagulants (DOACs) in cancer and other high-risk populations Academic Article
Venous Limb Gangrene during Warfarin Treatment of Cancer-Associated Deep Venous Thrombosis Academic Article
Venous and arterial thrombosis – pathogenesis and the rationale for anticoagulation Academic Article
Venous limb gangrene during overlapping therapy with warfarin and a direct thrombin inhibitor for immune heparin-induced thrombocytopenia Academic Article
Venous thromboembolism management: where do novel anticoagulants fit? Academic Article
Vimentin Exposed on Activated Platelets and Platelet Microparticles Localizes Vitronectin and Plasminogen Activator Inhibitor Complexes on Their Surface Academic Article
Volutrauma activates the clotting cascade in the newborn but not adult rat Academic Article
Von Willebrand factor and thrombin activation in children with newly diagnosed acute lymphoblastic leukemia: An impact of peripheral blasts Academic Article
Withdrawal of warfarin after deep vein thrombosis Academic Article
Ximelagatran or Warfarin for Stroke Prevention in Patients With Atrial Fibrillation? Academic Article
Ximelagatran versus Warfarin for the Prevention of Venous Thromboembolism after Total Knee Arthroplasty Academic Article
Zinc promotes clot stability by accelerating clot formation and modifying fibrin structure Academic Article
α2-Macroglobulin Remains as Important as Antithrombin III for Thrombin Regulation in Cord Plasma in the Presence of Endothelial Cell Surfaces Academic Article
γT-S195A thrombin reduces the anticoagulant effects of dabigatranin vitroandin vivo Academic Article

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