Thrombin Concept

subject area of

• 2 Mechanisms of action of low molecular weight heparins and heparinoids  Journal Articles
• In Vivo Formation of Protein Based Aqueous Microcompartments  Journal Articles
• A Barbourin-albumin Fusion Protein that Is Slowly Cleared In Vivo Retains the Ability to Inhibit Platelet Aggregation In Vitro  Journal Articles
• A Control Switch for Prothrombinase  Journal Articles
• A Graphene-Based Biosensing Platform Based on the Release of DNA Probes and Rolling Circle Amplification  Journal Articles
• A Protease TAMER: a nucleic acid‐based anticoagulant  Journal Articles
• A Role for Pericellular Proteoglycan in the Binding of Thrombin or Antithrombin III by the Blood Vessel Endothelium? – The Effects of Proteoglycan-Degrading Enzymes and Glycosaminoglycan-Binding Proteins on 125I-Thrombin Binding by the Rabbit Thoracic Aorta In Vitro  Journal Articles
• A Significant Portion of the Aequorin Luminescent Signal from Stimulated Human and Rabbit Platelets is Due to Exposure of the Aequorin to Calcium in the Suspending Medium  Journal Articles
• A long-lasting, plasmin-activatable thrombin inhibitor aids clot lysis in vitro and does not promote bleeding in vivo  Journal Articles
• A novel approach to thrombin inhibition  Journal Articles
• A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT)  Journal Articles
• A review of the oral direct thrombin inhibitor ximelagatran  Journal Articles
• A safety review of topical bovine thrombin-induced generation of antibodies to bovine proteins  Journal Articles
• A single dose of aprotinin prevents platelet hyporeactivity after coronary artery bypass graft surgery  Journal Articles
• A trypsin-like platelet protease propagates protease-activated receptor-1 cleavage and platelet activation  Journal Articles
• A549 Lung Epithelial Cells Synthesize Anticoagulant Molecules on the Cell Surface and Matrix and in Conditioned Media  Journal Articles
• AB023, A Novel Antibody That Binds Factor XI and Blocks Its Activation by Factor XIIa  Journal Articles
• Accumulation of the inositol phosphates in thrombin-stimulated, washed rabbit platelets in the presence of lithium  Journal Articles
• Acquired free protein S deficiency is associated with antiphospholipid antibodies and increased thrombin generation in patients with systemic lupus erythematosus  Journal Articles
• Activated thrombin‐activatable fibrinolysis inhibitor (TAFIa) attenuates fibrin‐dependent plasmin generation on thrombin‐activated platelets  Journal Articles
• Activated thrombin‐activatable fibrinolysis inhibitor is generated in vivo at levels that can substantially affect fibrinolysis in chimpanzees in response to thrombin generation  Journal Articles
• Activation of blood coagulation by plaque rupture: Mechanisms and prevention  Journal Articles
• Activation of factor V during intrinsic and extrinsic coagulation. Inhibition by heparin, hirudin and d-Phe-Pro-Arg-Ch2Cl  Journal Articles
• Activation of factor X and prothrombin in antithrombin-III depleted plasma: The effects of heparin  Journal Articles
• Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells  Journal Articles
• Active thrombin produced by the intestinal epithelium controls mucosal biofilms  Journal Articles
• Acute coronary syndromes: a focus on thrombin.  Journal Articles
• Acute in vitro effects of ethanol on responses of platelets from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits.  Journal Articles
• Adenine nucleotides in thrombin-degranulated platelets: Effect of prolonged circulation in vivo  Other
• Adjunctive Use of Direct Thrombin Inhibitors in Patients Receiving Fibrinolytic Therapy for Acute Myocardial Infarction  Journal Articles
• Adsorption of thrombin from buffer and modified plasma to polystyrene resins containing sulphonate and sulphamide arginyl methyl ester groups  Journal Articles
• Advances in the management of venous thromboembolism  Journal Articles
• Advances in the management of venous thromboembolism.  Journal Articles
• Affinity Analysis of a Protein−Aptamer Complex Using Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures  Journal Articles
• Age‐related changes in factor VII proteolysis in vivo  Journal Articles
• Allosteric modulation of exosite 1 attenuates polyphosphate-catalyzed activation of factor XI by thrombin  Journal Articles
• Alpha-1 proteinase inhibitor M358R reduces thrombin generation when displayed on the surface of cells expressing tissue factor  Journal Articles
• Alpha-2-Macroglobulin Is an Important Progressive Inhibitor of Thrombin in Neonatal and Infant Plasma  Journal Articles
• Alpha-2-macroglobulin may provide protection from thromboembolic events in antithrombin III-deficient children  Journal Articles
• Altered inactivation of trinitrophenylated thrombin by antithrombin iii in the presence of heparin  Journal Articles
• Altering Heparin Cofactor II at VAL439 (P6) either Impairs Inhibition of Thrombin or Confers Elastase Resistance  Journal Articles
• Amino acid substitutions of the P2 residue of human antithrombin that either enhance or impair function  Journal Articles
• An Approach to Assigning In Vitro Potency to Unfractionated and Low Molecular Weight Heparins Based on the Inhibition of Prothrombin Activation and Catalysis of Thrombin Inhibition  Journal Articles
• An Overview of the Heparin-Induced Thrombocytopenia Syndrome  Journal Articles
• An acquired factor V inhibitor associated with defective factor V function, storage and binding to multimerin 1  Journal Articles
• An anticoagulant dermatan sulfate proteoglycan circulates in the pregnant woman and her fetus.  Journal Articles
• An overview of the mechanism of action of antithrombin and its inherited deficiency states  Journal Articles
• Analysis of Inhibition Rate Enhancement by Covalent Linkage of Antithrombin to Heparin as a Potential Predictor of Reaction Mechanism  Journal Articles
• Another oral thrombin inhibitor for stroke prevention in atrial fibrillation?  Journal Articles
• Anticoagulant Effects of Heparin in Neonatal Plasma'  Journal Articles
• Anticoagulants in heart disease: current status and perspectives  Journal Articles
• Antithrombin III Sudbury: An Ala384 → pro mutation with abnormal thrombin-binding activity and thrombotic diathesis  Journal Articles
• Antithrombin III-beta associates more readily than antithrombin III-alpha with uninjured and de-endothelialized aortic wall in vitro and in vivo.  Journal Articles
• Antithrombin-Heparin Covalent Complex  Journal Articles
• Antithrombin-III-Hamilton, Ala 382 to Thr: an antithrombin-III variant that acts as a substrate but not an inhibitor of alpha-thrombin and factor Xa  Journal Articles
• Antithrombin-III-Hamilton: a gene with a point mutation (guanine to adenine) in codon 382 causing impaired serine protease reactivity  Journal Articles
• Antithrombin-III-Stockholm: a codon 392 (Gly----Asp) mutation with normal heparin binding and impaired serine protease reactivity  Journal Articles
• Antithrombotic Agents  Journal Articles
• Antithrombotic Properties of Heparin in a Neonatal Piglet Model of Thrombin-Induced Thrombosis  Journal Articles
• Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention  Journal Articles
• Arachidonate induced fibrinogen binding to thrombin degranulated platelets is independent of released ADP  Other
• Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein  Journal Articles
• Association of fibrinogen with human platelets pretreated with chymotrypsin or aggregated with ADP or thrombin: an immunocytochemical study  Journal Articles
• Atorvastatin Delays Murine Platelet Activation In Vivo Even in the Absence of Endothelial NO Synthase  Journal Articles
• Batroxobin Binds Fibrin with Higher Affinity and Promotes Clot Expansion to a Greater Extent than Thrombin  Journal Articles
• Benefit of Selective Factor Inhibition  Journal Articles
• Beyond Unfractionated Heparin and Warfarin  Journal Articles
• Binding of Aggregated Immunoglobulins to the Human Platelet Fc Receptors: A Mechanism of Platelet to Platelet Bridging  Journal Articles
• Binding of Thrombin to the G-protein-linked Receptor, and Not to Glycoprotein Ib, Precedes Thrombin-mediated Platelet Activation  Journal Articles
• Biologic rationale for the therapeutic role of specific antithrombins  Journal Articles
• Biological Action of Colorless and Yellow Solutions of Gold Sodium Thiomalate on Thrombin Activity and the Mixed Lymphocyte Reaction  Journal Articles
• Bioregulatory roles for fibrin(ogen) on blood coagulation  Journal Articles
• Bivalent Binding to γA/γ′-Fibrin Engages Both Exosites of Thrombin and Protects It from Inhibition by the Antithrombin-Heparin Complex  Journal Articles
• Bivalirudin, thrombin and platelets: clinical implications and future directions.  Journal Articles
• Blood tests for the diagnosis of venous and arterial thrombosis  Journal Articles
• Breast cancer chemotherapy induces the release of cell‐free DNA, a novel procoagulant stimulus  Journal Articles
• By Increasing the Affinity of Heparin for Fibrin, Zn²⁺ Promotes the Formation of a Ternary Heparin–Thrombin–Fibrin Complex That Protects Thrombin from Inhibition by Antithrombin  Journal Articles
• Cardiovascular outcomes, bleeding risk, and achieved blood pressure in patients on long-term anticoagulation with the thrombin antagonist dabigatran or warfarin: data from the RE-LY trial  Journal Articles
• Catalysis of Thrombin Inhibition Provides an Index for Estimating the Antithrombotic Potential of Glycosaminoglycans in Rabbits  Journal Articles
• Challenges with heparin-based anticoagulation during cardiopulmonary bypass in children: Impact of low antithrombin activity  Journal Articles
• Changes in the platelet phosphoinositides during the first minute after stimulation of washed rabbit platelets with thrombin  Journal Articles
• Characteristics of Thrombin-Degranulated Human Platelets: Development of a Method that Does not Use Proteolytic Enzymes for Deaggregation  Journal Articles
• Characterization of the C-terminal Domain of a Potassium Channel from Streptomyces lividans (KcsA)  Journal Articles
• Chromatography of heparin on Sepharose–lysine: molecular size fractionation and its relevance to thrombin and antithrombin III binding  Journal Articles
• Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.  Journal Articles
• Coagulation Assays  Journal Articles
• Coagulation factor XIII and markers of thrombin generation and fibrinolysis in patients with inflammatory bowel disease  Journal Articles
• Comment: Treatment of Heparin-Induced Thrombocytopenia  Journal Articles
• Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development  Journal Articles
• Comparative behavior of thrombin and an inactive derivative, FPR-thrombin, toward the rabbit vascular endothelium. Heparin liberates FPR-thrombin from the endothelium in vivo.  Journal Articles
• Comparative effects of heparin and LMW heparin on hemostasis  Conferences
• Comparative metabolism and distribution of rabbit heparin cofactor II and rabbit antithrombin in rabbits  Journal Articles
• Comparison of Heparin- and Dermatan Sulfate-mediated Catalysis of Thrombin Inactivation by Heparin Cofactor II  Journal Articles
• Comparison of mammalian and bacterial expression library screening to detect recombinant alpha-1 proteinase inhibitor variants with enhanced thrombin inhibitory capacity☆  Journal Articles
• Comparison of the Effects of Heparin and Hirudin on Thrombin Binding to the Normal and the De-Endothelialized Rabbit Aorta In Vitro  Journal Articles
• Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA  Journal Articles
• Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the organization to assess strategies in acute ischemic syndromes (OASIS)‐5 trial  Journal Articles
• Comparison of three‐factor and four‐factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers  Journal Articles
• Conditions influencing platelet lysis  Other
• Conformational Changes in Thrombin When Complexed by Serpins  Journal Articles
• Contrasting Effects of Thrombin and the Thrombin Receptor Peptide, SFLLRN, on Aggregation and Release of 14C-Serotonin by Human Platelets Pretreated with Chymotrypsin or Serratia marcescens Protease  Other
• Control Mechanisms in Thrombin Generation  Journal Articles
• Coordinate Activation of Human Platelet Protease-activated Receptor-1 and -4 in Response to Subnanomolar α-Thrombin  Journal Articles
• Covalent antithrombin-heparin effect on thrombin-thrombomodulin and activated protein C reaction with factor V/Va  Journal Articles
• Current anticoagulant therapy—unmet clinical needs  Conferences
• DOAC–associated bleeding, hemostatic strategies, and thrombin generation assays - a review of the literature  Journal Articles
• Dabigatran Etexilate  Journal Articles
• Dabigatran Etexilate: Future Directions in Anticoagulant Treatment  Journal Articles
• Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function  Journal Articles
• Dabigatran attenuates thrombin generation to a lesser extent than warfarin: could this explain their differential effects on intracranial hemorrhage and myocardial infarction?  Journal Articles
• Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve‐Induced Thrombin Generation  Journal Articles
• Dabigatran monitoring made simple?  Journal Articles
• Deaggregation of Human Platelets Aggregated by Thrombin  Journal Articles
• Decreased Concentrations of Heparinoids Are Required to Inhibit Thrombin Generation in Plasma from Newborns and Children Compared to Plasma from Adults due to Reduced Thrombin Potential  Journal Articles
• Decreased Thrombin Activity of Fibrin Clots Prepared in Cord Plasma Compared with Adult Plasma  Journal Articles
• Deendothelialization in vivo initiates a thrombogenic reaction at the rabbit aorta surface. Correlation of uptake of fibrinogen and antithrombin III with thrombin generation by the exposed subendothelium.  Journal Articles
• Degranulation of Human Platelets by the Thrombin Receptor Peptide SFLLRN: Comparison with Degranulation by Thrombin  Journal Articles
• Delayed but not Early Treatment with DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis  Journal Articles
• Deletion mutagenesis of heparin cofactor II: defining the minimum size of a thrombin inhibiting serpin  Journal Articles
• Detection of human fetal fibrinogen in umbilical cord plasma by parallel assays of immunoreactive and thrombin-clottable protein.  Journal Articles
• Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency.  Journal Articles
• Development of nonthrombogenicity of injured rabbit aortas despite inhibition of platelet adherence  Other
• Developmental haemostasis  Journal Articles
• Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet‐mediated events during thrombus formation  Journal Articles
• Differences between platelet phosphoinositide metabolism stimulated by thrombin or SFLLRN are not accounted for by interaction of thrombin with glycoprotein Ib  Journal Articles
• Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation  Journal Articles
• Direct Factor Xa and direct thrombin inhibitors: a clinical trial update.  Journal Articles
• Direct Thrombin Inhibitors in Acute Coronary Syndromes  Journal Articles
• Direct Thrombin Inhibitors in Cardiac Disease  Journal Articles
• Direct thrombin inhibitors  Journal Articles
• Direct thrombin inhibitors in acute coronary syndromes  Journal Articles
• Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention  Journal Articles
• Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data  Journal Articles
• Displacement of Fibrin-bound Thrombin by r-Hirudin Precludes the Use of 131l-r-Hirudin for Detecting Pulmonary Emboli in the Rabbit  Journal Articles
• Disseminated Intravascular Coagulation [Abridged]  Journal Articles
• Divalent cations and the release reaction of pig platelets  Journal Articles
• Do Coagulation Screening Tests Detect Increased Generation of Thrombin and Plasmin in Sick Newborn Infants?  Journal Articles
• Does an enzyme other than thrombin contribute to unexpected changes in the levels of the different forms of thrombin activatable fibrinolysis inhibitor in patients with hemophilia A, hemophilia B and von Willebrand disease?  Journal Articles
• Drug Effects on Platelet Adherence to Collagen and Damaged Vessel Walls \textbar Request PDF  Other
• Dual Pathway Inhibition for Vascular Protection in Patients with Atherosclerotic Disease: Rationale and Review of the Evidence  Journal Articles
• EFFECT OF SERA ON THROMBIN ACTIVATION RATE CONSTANTS: A ONE‐STAGE ASSAY OF THE EXTRINSIC SYSTEM  Journal Articles
• Early Intraplatelet Signaling Enhances the Release of Human Platelet PAR-1 and -4 Amino-Terminal Peptides in Response to Thrombin  Journal Articles
• Effect of Covalent Serpin–Heparinoid Complexes on Plasma Thrombin Generation on Fetal Distal Lung Epithelium  Journal Articles
• Effect of Heparin Loading During Congenital Heart Operation on Thrombin Generation and Blood Loss  Journal Articles
• Effect of Nonspecific Binding to Plasma Proteins on the Antithrombin Activities of Unfractionated Heparin, Low-Molecular-Weight Heparin, and Dermatan Sulfate  Journal Articles
• Effect of Repeated Treatment of Rabbit Platelets with Low Concentrations of Thrombin on their Function, Metabolism and Survival  Journal Articles
• Effect of Streptokinase on Hemostasis  Journal Articles
• Effect of a novel covalent antithrombin-heparin complex on thrombin generation on fetal distal lung epithelium  Journal Articles
• Effect of diet-induced hyperlipidemia on in vitro-function of rabbit platelets  Other
• Effect of disease and chemotherapy on hemostasis in children with acute lymphoid leukemia.  Journal Articles
• Effect of gaboon viper (Bitis gabonica) venom on blood coagulation, platelets, and the fibrinolytic enzyme system  Journal Articles
• Effect of heparins on thrombin generation in hemophilic plasma supplemented with FVIII, FVIIa, or FEIBA.  Journal Articles
• Effect of ionophore A23, 187 on thrombin-degranulated washed rabbit platelets  Other
• Effect of substrate and fibrin polymerization inhibitor on determination of plasma thrombin generation in vitro  Journal Articles
• Effects of Cathepsin G Pretreatment of Platelets on their Subsequent Responses to Aggregating Agents  Journal Articles
• Effects of Dermatan Sulfate and Heparin on Inhibition of Thrombus Growth in Vivo  Journal Articles
• Effects of Ethanol on Pathways of Platelet Aggregation In Vitro  Journal Articles
• Effects of Intermittent Pneumatic Calf Compression On Postoperative Thrombin and Plasmin Activity  Journal Articles
• Effects of Sulfated Polysaccharides on Inhibition of Thrombus Formation initiated by Different Stimuli  Journal Articles
• Effects of Thrombin and the Thrombin Receptor Activating Peptide, SFLLRN, on Redistribution of Platelet α-Granule Contents Are Similar and Independent of the Extent of Thromboxane Formation  Journal Articles
• Effects of Tris on Responses of Human and Rabbit Platelets to Aggregating Agents  Journal Articles
• Effects of external Ca2+ and Mg2+ on thrombin-induced changes in Ca2+ and Mg2+ of pig platelets  Other
• Effects of heparin fractions of different affinities to antithrombin III and thrombin on the inactivation of thrombin and factor Xa by antithrombin III  Journal Articles
• Effects on Thrombin Generation of Single Injections of Hirulog™ in Patients with Calf Vein Thrombosis  Journal Articles
• Elevated Fibrinopeptide A and B Levels during Thrombolytic Therapy: Real or Artefactual?  Journal Articles
• Enhanced binding of fibrinogen by the subendothelium after treatment of the rabbit aorta with thrombin.  Journal Articles
• Evaluation of DNA aptamers directed to thrombin as potential thrombus imaging agents  Journal Articles
• Evidence That Both Exosites on Thrombin Participate in Its High Affinity Interaction with Fibrin  Journal Articles
• Evidence for Allosteric Linkage between Exosites 1 and 2 of Thrombin  Journal Articles
• Evidence for an alternative mechanism of human platelet secretion involving peripheralization of secretory granules and formation of membrane-associated multivesicular structures  Journal Articles
• Evidence for thrombin binding to dermatan sulphate sites in the rabbit aorta subendothelium in vitro  Journal Articles
• Evolution of a highly functional circular DNA aptamer in serum  Journal Articles
• Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin–Thrombomodulin Complex  Journal Articles
• Exosites 1 and 2 Are Essential for Protection of Fibrin-bound Thrombin from Heparin-catalyzed Inhibition by Antithrombin and Heparin Cofactor II  Journal Articles
• Expression in a cell-free system of normal and variant forms of human antithrombin III. Ability to bind heparin and react with alpha-thrombin  Journal Articles
• Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity  Journal Articles
• Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood  Journal Articles
• Extracellular Histones Increase Tissue Factor Activity and Enhance Thrombin Generation by Human Blood Monocytes  Journal Articles
• Factor Xa and thrombin as targets for new oral anticoagulants  Journal Articles
• Factor Xa or thrombin: Is thrombin a better target?  Conferences
• Factors Influencing the Deaggregation of Human and Rabbit Platelets  Journal Articles
• Factors responsible for ADP-induced release reaction of human platelets  Other
• Familial thrombophilia and the prothrombin 20210A mutation  Journal Articles
• Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists  Journal Articles
• Fate of Thrombin and Thrombin-Antithrombin-III Complex Adsorbed to a Heparinized Biomaterial: Analysis of the Enzyme-Inhibitor Complexes Displaced by Plasma  Journal Articles
• Fibrin and Thrombin Sealants in Vascular and Cardiac Surgery: A Systematic Review and Meta-analysis  Journal Articles
• Fibrin moderates the catalytic action of heparin but not that of dermatan sulfate on thrombin inhibition in human plasma.  Journal Articles
• Fibrinogenolysis and thrombin generation after reduced dose bolus or conventional rt-PA for pulmonary embolism. The Coagulation Project Investigators of the Bolus Alteplase Pulmonary Embolism Group.  Journal Articles
• Fibrinolytic properties of lysine‐derivatized polyethylene in contact with flowing whole blood (Chandler loop model)  Journal Articles
• Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors  Journal Articles
• Fluorous Analogue of Chloramine-T: Preparation, X-ray Structure Determination, and Use as an Oxidant for Radioiodination and s-Tetrazine Synthesis  Journal Articles
• Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT) – Bridging the River Coumarin  Journal Articles
• Full or Partial Substitution of the Reactive Center Loop of α-1-Proteinase Inhibitor by that of Heparin Cofactor II:  P1 Arg Is Required for Maximal Thrombin Inhibition  Journal Articles
• Further Studies on the Mechanisms for the Antithrombotic Effects of Sulfated Polysaccharides in Rabbits  Journal Articles
• Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition  Journal Articles
• G-Protein–Coupled Receptors as Signaling Targets for Antiplatelet Therapy  Journal Articles
• Global haemostasis and point of care testing  Journal Articles
• Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors  Journal Articles
• HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase  Journal Articles
• HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions  Journal Articles
• HUMAN PLATELET THROMBIN RECEPTORS  Journal Articles
• Hemophilia and von Willebrand's disease: 2. Management. Association of Hemophilia Clinic Directors of Canada.  Journal Articles
• Heparan sulfate and dermatan sulfate inhibit the generation of thrombin activity in plasma by complementary pathways  Journal Articles
• Heparan sulfate and dermatan sulfate inhibit the generation of thrombin activity in plasma by complementary pathways.  Journal Articles
• Heparan sulfate: Antithrombotic or not?  Journal Articles
• Heparin Cofactor II and Other Endogenous Factors in the Mediation of the Antithrombotic and Anticoagulant Effects of Heparin and Dermatan Sulfate  Journal Articles
• Heparin and Low Molecular Weight Heparins Inhibit Prothrombinase Formation but not its Activity in Plasma  Journal Articles
• Heparin inhibits thrombin binding to rabbit thoracic aorta endothelium.  Journal Articles
• Heparin sensitivity and resistance in the neonate: An explanation  Journal Articles
• Heparin with low affinity to antithrombin III inhibits the activation of prothrombin in normal plasma  Journal Articles
• Heparin-Induced Thrombocytopenia: A Ten-Year Retrospective  Journal Articles
• Heparin-Induced thrombocytopenia: IgG-Mediated platelet activation, platelet microparticle generation, and altered procoagulant/anticoagulant balance in the pathogenesis of thrombosis and venous limb gangrene complicating heparin-Induced thrombocytopenia  Journal Articles
• Heparin-induced thrombocytopenia in intensive care patients  Journal Articles
• Heparin-induced thrombocytopenia in the critical care setting: Diagnosis and management^  Journal Articles
• Heparin‐induced thrombocytopenia – therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhibit formation of platelet factor 4–heparin complexes  Journal Articles
• Heparin‐induced thrombocytopenia: pathogenesis and management  Journal Articles
• High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13  Journal Articles
• Hirulog in the Treatment of Unstable Angina  Journal Articles
• Histidine-rich Glycoprotein Binds Fibrin(ogen) with High Affinity and Competes with Thrombin for Binding to the γ′-Chain  Journal Articles
• Histidine-rich glycoprotein attenuates catheter thrombosis  Journal Articles
• Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway  Journal Articles
• Human platelets contain forms of factor V in disulfide-linkage with multimerin  Journal Articles
• Human tissue-type plasminogen activator releases fibrinopeptides A and B from fibrinogen.  Journal Articles
• Hypercoagulability after trauma: Hemostatic changes and relationship to venous thromboembolism  Journal Articles
• IMMUNOCYTOCHEMICAL LOCALIZATION OF FIBRINOGEN DURING THROMBIN-INDUCED AGGREGATION OF HUMAN PLATELETS  Other
• IMPACT OF MUTATIONS AT THE P4 AND P5 POSITIONS ON THE REACTION OF ANTITHROMBIN WITH THROMBIN AND ELASTASE  Journal Articles
• INHIBITION OF THROMBIN BY HIRUDIN GENETICALLY FUSED TO WILD-TYPE OR MUTANT ANTITHROMBIN  Journal Articles
• INVESTIGATION OF THE PATHOLOGICAL EFFECTS OF HISTONES, DNA, AND NUCLEOSOMES IN A MURINE MODEL OF SEPSIS  Journal Articles
• Identification of Dp71 Isoforms in the Platelet Membrane Cytoskeleton  Journal Articles
• Identification of the MMRN1 Binding Region within the C2 Domain of Human Factor V  Journal Articles
• Identification of the histidine‐rich glycoprotein domains responsible for contact pathway inhibition  Journal Articles
• Immune Responses Associated With Perioperative Exposure and Reexposure to Topical Bovine Thrombin Do Not Impair Hemostasis  Journal Articles
• Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients  Journal Articles
• In Vitro and in Vivo Functions of Thrombin-Treated Platelets \textbar Request PDF  Journal Articles
• In Vivo Clearance of Ternary Complexes of Vitronectin-Thrombin-Antithrombin Is Mediated by Hepatic Heparan Sulfate Proteoglycans  Journal Articles
• In the Presence of Phospholipids, Glycosaminoglycans Potentiate Factor Xa-Mediated Protein C Activation by Modulating Factor Xa Activity  Journal Articles
• In vivo behaviour of some antithrombin III-protease complexes.  Journal Articles
• In vivo photoactivation of caged thrombin.  Journal Articles
• Inactivation of thrombin by antithrombin III on a heparinized biomaterial  Journal Articles
• Increased sulphation improves the anticoagulant activities of heparan sulphate and dermatan sulphate  Journal Articles
• Increased thrombin generation and activity in patients with systemic lupus erythematosus and anticardiolipin antibodies: evidence for a prothrombotic state [see comments]  Journal Articles
• Influence of Mechanical Stretch on Thrombin Regulation by Fetal Mixed Lung Cells  Journal Articles
• Influence of activated factor VII concentrates on thrombin generation in full-term and preterm neonates  Journal Articles
• Influence of exogenous factor VIIa on thrombin generation in cord plasma of full-term and pre-term newborns  Journal Articles
• Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation  Journal Articles
• Inhibition of Fibrin-Bound Thrombin by a Covalent Antithrombin-Heparin Complex  Journal Articles
• Inhibition of Thrombin by Antithrombin III and Heparin Cofactor II In Vivo  Journal Articles
• Inhibition of Thrombin-Neutralizing Activity of Antithrombin III by Steroid Hormones  Journal Articles
• Inhibition of factor X and factor V activation by dermatan sulfate and a pentasaccharide with high affinity for antithrombin III in human plasma  Journal Articles
• Inhibition of factor X, factor V and prothrombin activation by the bis(lactobionic acid amide) LW10082  Journal Articles
• Inhibition of platelet-dependent prothrombinase activity and thrombin generation by glycoprotein IIb/IIIa receptor-directed antagonists: potential contributing mechanism of benefit in acute coronary syndromes.  Journal Articles
• Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors of α-thrombin  Journal Articles
• Inhibition of thrombin by antithrombin III in the presence of certain glycosaminoglycans found in the mammalian aorta  Journal Articles
• Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia  Journal Articles
• Injury Of Cultured Endothelial Cells By Thrombin-Stimulated Platelets  Other
• Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome  Journal Articles
• Interactions of polylysine with platelets  Other
• Interactions of thermally denatured fibrinogen on polyethylene with plasma proteins and platelets  Journal Articles
• Intravascular Haemolysis with Experimentally Produced Vascular Thrombi  Journal Articles
• Investigation of the Anticoagulant Mechanisms of a Covalent Antithrombin-Heparin Complex  Journal Articles
• Investigation of the Mechanism of False Positive ¹²⁵I‐Labelled Fibrinogen Scans  Journal Articles
• Kinetic Analysis of a Unique Direct Prothrombinase, fgl2, and Identification of a Serine Residue Critical for the Prothrombinase Activity  Journal Articles
• Lack of Relationship Between Enhanced Bleeding Induced by Heparin and Other Sulfated Polysaccharides and Enhanced Catalysis of Thrombin Inhibition  Journal Articles
• Lack of Stability of Aggregates after Thrombin-Induced Reaggregation of Thrombin-Degranulated Platelets  Journal Articles
• Localization of fibrinogen during ADP- or thrombin-induced aggregation of washed rabbit platelets  Journal Articles
• Localization of the Thrombin-binding Domain on Prothrombin Fragment 2  Journal Articles
• Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function  Journal Articles
• Lubricant‐Infused PET Grafts with Built‐In Biofunctional Nanoprobes Attenuate Thrombin Generation and Promote Targeted Binding of Cells  Journal Articles
• Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential  Journal Articles
• Management of Patients with Acute Coronary Syndromes  Journal Articles
• Mechanism of inhibition of the prothrombinase complex by a covalent antithrombin-heparin complex  Journal Articles
• Mechanism of platelet shape change, aggregation, and release induced by collagen, thrombin, or A23,187 \textbar Request PDF  Other
• Mechanisms Responsible for Catalysis of the Inhibition of Factor Xa or Thrombin by Antithrombin Using a Covalent Antithrombin-Heparin Complex  Journal Articles
• Mechanisms for Inhibition of the Generation of Thrombin Activity by Sulfated Polysaccharides^a  Journal Articles
• Mechanisms for the anticoagulant effect of heparin and related polysaccharides.  Journal Articles
• Mechanisms of Action of Heparin: Applications to the Development of Derivatives of Heparin and Heparinoids with Antithrombotic Properties  Journal Articles
• Meeting the Unmet Needs in Anticoagulant Therapy  Journal Articles
• Microheterogeneity of antithrombin III  Journal Articles
• Modes and consequences of thrombin's interaction with fibrin  Journal Articles
• Modulation of intrinsic prothrombin activation by fibrinogen and fibrin I.  Journal Articles
• Modulation of the Enzymatic Activity of α-Thrombin by Polyanions: Consequences on Intrinsic Activation of Factor V and Factor VIII  Journal Articles
• Molecular Basis for the Resistance of Fibrin-Bound Thrombin to Inactivation by Heparin/Serpin Complexes  Journal Articles
• Molecular Basis for the Susceptibility of Fibrin-bound Thrombin to Inactivation by Heparin Cofactor II in the Presence of Dermatan Sulfate but Not Heparin  Journal Articles
• Molecular basis of inherited human antithrombin deficiency  Journal Articles
• Molecular cloning and expression of rabbit antithrombin III  Journal Articles
• Morphological analysis of microparticle generation in heparin-induced thrombocytopenia  Journal Articles
• Multicentric warfarin-induced skin necrosis complicating heparin-induced thrombocytopenia  Journal Articles
• Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation  Journal Articles
• NMR Structures Reveal How Oxidation Inactivates Thrombomodulin  Journal Articles
• Neutralization of Enoxaparine-lnduced Bleeding by Protamine Sulfate  Journal Articles
• Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms  Journal Articles
• New Anticoagulant Strategies  Journal Articles
• New Anticoagulant Therapy  Journal Articles
• New Anticoagulants  Journal Articles
• New Antithrombotic Drugs  Journal Articles
• New Antithrombotics  Journal Articles
• New anticoagulant strategies.  Journal Articles
• New anticoagulants  Conferences
• New aspects on treatment modalities for thromboembolic episodes  Journal Articles
• New method for packing the external auditory canal, middle ear space, and mastoid cavities after otologic surgery  Journal Articles
• New oral anticoagulants in atrial fibrillation  Journal Articles
• New oral anticoagulants in development  Journal Articles
• New oral anticoagulants: which one should my patient use?  Journal Articles
• New pharmacotherapy for stroke prevention in atrial fibrillation: Update 2010  Journal Articles
• Novel Oral Factor Xa and Thrombin Inhibitors in the Management of Thromboembolism  Journal Articles
• Novel anticoagulant agents: introduction  Journal Articles
• Novel paediatric anticoagulants: a review of the current literature  Journal Articles
• On the interaction of rabbit antithrombin III with the luminal surface of the normal and deendothelialized rabbit thoracic aorta in vitro  Journal Articles
• Only high levels of dabigatran attenuate catheter thrombosis in vitro and in rabbits  Journal Articles
• Orally Active Direct Thrombin Inhibitors  Journal Articles
• Organ Distribution of Fibrin in Disseminated Intravascular Coagulation  Journal Articles
• Overexpression of the 78-kDa Glucose-regulated Protein/Immunoglobulin-binding Protein (GRP78/BiP) Inhibits Tissue Factor Procoagulant Activity  Journal Articles
• Parenteral Anticoagulants  Journal Articles
• Pathobiologic features and prevention of thrombotic complications associated with prosthetic heart valves: Fundamental principles and the contribution of platelets and thrombin  Journal Articles
• Pathways responsible for platelet hypersensitivity in rats with diabetes. I. Streptozocin-induced diabetes  Other
• Pathways responsible for platelet hypersensitivity in rats with diabetes. II. Spontaneous diabetes in BB Wistar rats  Other
• Peptide modified gold-coated polyurethanes as thrombin scavenging surfaces  Journal Articles
• Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin  Journal Articles
• Pharmacology and Clinical Potential of Direct Thrombin Inhibitors  Journal Articles
• Phosphatidylinositol 4,5-bisphosphate is selectively retained by platelet-fibrin clots formed by thrombin  Journal Articles
• Plasma Anticoagulant Mechanisms of Heparin, Heparan Sulfate, and Dermatan Sulfatea  Journal Articles
• Plasma Thrombin Neutralization Assay: Pharmacokinetic Applications  Journal Articles
• Plasmin accelerates platelet‐dependent prothrombinase formation without activating the platelets  Journal Articles
• Platelet Adherence to the Vessel Wall and to Collagen-Coated Surfaces \textbar Request PDF  Other
• Platelet Interactions with the Endothelium and the Subendothelium: the Role of Thrombin and Prostacyclin  Journal Articles
• Platelet factor V New York: A defect in factor V distinct from that in factor V Quebec resulting in impaired prothrombinase generation  Journal Articles
• Platelet function and survival in rats with genetically determined hypercholesterolaemia  Journal Articles
• Platelet sialic acid and platelet survival after aggregation by ADP  Other
• Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non‐valvular atrial fibrillation from the RE‐LY trial  Journal Articles
• Preclinical differentiation of low molecular weight heparins.  Journal Articles
• Predictors of clinical outcome in patients with heparin-induced thrombocytopenia treated with direct thrombin inhibition  Journal Articles
• Pretreatment of Human Platelets with Plasmin Inhibits Responses toThrombin, but Potentiates Responses to Low Concentrations of Aggregating Agents, Including the Thrombin Receptor Activating Peptide, SFLLRN  Journal Articles
• Prevention of Thrombus Growth by Antithrombin III-Dependent and Two Direct Thrombin Inhibitors in Rabbits: Implications for Antithrombotic Therapy  Journal Articles
• Prevention of activation of blood coagulation during acute coronary ischemic syndromes beyond aspirin and heparin  Journal Articles
• Prevention of thrombus formation and growth by antithrombin III and heparin cofactor II-dependent thrombin inhibitors: Importance of heparin cofactor II  Journal Articles
• Proceedings: Inhibition of collagen- or thrombin-induced shape change of rabbit platelets  Journal Articles
• Prognostic utility and characterization of cell-free DNA in patients with severe sepsis  Journal Articles
• Prolonged Antithrombin Activity of Low-Molecular-Weight Heparins  Journal Articles
• Prolonged Expression of Procoagulant Activity of Human Platelets Degranulated by Thrombin  Journal Articles
• Prolonged in vivo anticoagulant activity of a hirudin–albumin fusion protein secreted from Pichia pastoris  Journal Articles
• Properties of Washed Human Platelets  Journal Articles
• Protease activated receptors 1 and 4 govern the responses of human platelets to thrombin  Journal Articles
• Protein‐Mediated Suppression of Rolling Circle Amplification for Biosensing with an Aptamer‐Containing DNA Primer  Journal Articles
• Purification of silica‐free DNA and characterization of its role in coagulation  Journal Articles
• Quality Control Certification of RNA Aptamer‐Based Detection  Journal Articles
• RESOLUTION OF ACUTE MASSIVE PULMONARY EMBOLISM AFTER PULMONARY ARTERIAL INFUSION OF STREPTOKINASE  Journal Articles
• Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy  Other
• Radiolabeled r-Hirudin as a Measure of Thrombin Activity at, or within, the Rabbit Aorta Wall In Vitro and In Vivo  Journal Articles
• Randomized phase 2 trial comparing JNJ‐9375, a thrombin‐directed antibody, with apixaban for prevention of venous thrombosis  Journal Articles
• Reactions of 14C-ADP and 14C-ATP with washed platelets from rabbits  Other
• Recurrence of Dialysis Shunt Pseudoaneurysm Following Percutaneous Thrombin Embolization  Journal Articles
• Reduced Plasminogen Binding and Delayed Activation Render γ′-Fibrin More Resistant to Lysis than γA-Fibrin  Journal Articles
• Reduction of thrombus size in murine models of thrombosis following administration of recombinant α1-proteinase inhibitor mutant proteins  Journal Articles
• Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates  Journal Articles
• Requirement of Lysine Residues Outside of the Proposed Pentasaccharide Binding Region for High Affinity Heparin Binding and Activation of Human Antithrombin III  Journal Articles
• Reversing anticoagulants both old and new.  Journal Articles
• Review: Laboratory markers quantifying prothrombin activation and actions of thrombin in venous and arterial thrombosis do not accurately assess disease severity or the effectiveness of treatment  Journal Articles
• Rivaroxaban and Dabigatran for Suppression of Mechanical Heart Valve–Induced Thrombin Generation  Journal Articles
• Rivaroxaban and apixaban are less effective than enoxaparin for the prevention of catheter-induced clotting in vitro  Journal Articles
• Safety and Efficacy of Thrombin-JMI: A Multidisciplinary Expert Group Consensus  Journal Articles
• Secondary Prevention of Venous Thromboembolism with the Oral Direct Thrombin Inhibitor Ximelagatran  Journal Articles
• Serum-induced platelet procoagulant activity: An assay for the characterization of prothrombotic disorders  Journal Articles
• Shortening of the Bleeding Time in Rabbits by Hydrocortisone Caused by Inhibition of Prostacyclin Generation by the Vessel Wall  Journal Articles
• Site‐directed mutagenesis of the P2 residue of human antithrombin  Journal Articles
• Sodium Arachidonate Can Induce Platelet Shape Change and Aggregation Which Are Independent of the Release Reaction  Journal Articles
• State-of-the-Art Mini Review: Dual-Pathway Inhibition to Reduce Arterial and Venous Thromboembolism  Journal Articles
• State-of-the-Art-Review : Statins Induce Hypothrombotic States?  Journal Articles
• Statins and Thrombin  Journal Articles
• Streptokinase and rt-PA activate platelets by a different way: implications on the rethrombosis rate after their administration in myocardial infarction.  Journal Articles
• Structural Effects of a Covalent Linkage Between Antithrombin and Heparin: Covalent N-Terminus Attachment of Heparin Enhances the Maintenance of Antithrombin's Activated State  Journal Articles
• Structure-Switching Signaling Aptamers  Journal Articles
• Studies investigating platelet aggregation and release initiated by sera from patients with thrombotic thrombocytopenic purpura  Journal Articles
• Studies on the coagulant enzyme from Agkistrodon rhodostoma venom. Isolation and some properties of the enzyme  Journal Articles
• Surface modification with PEG and hirudin for protein resistance and thrombin neutralization in blood contact  Journal Articles
• Synergism between platelet aggregating agents: The role of the arachidonate pathway  Journal Articles
• Synthesis and radioiodination of a stannyl oligodeoxyribonucleotide  Journal Articles
• THE EFFECTS OF DNASE I AND LOW-MOLECULAR-WEIGHT HEPARIN IN A MURINE MODEL OF POLYMICROBIAL ABDOMINAL SEPSIS  Journal Articles
• Targeting Tumor Vasculature With an Oncolytic Virus  Journal Articles
• Target‐Dependent Protection of DNA Aptamers against Nucleolytic Digestion Enables Signal‐On Biosensing with Toehold‐Mediated Rolling Circle Amplification  Journal Articles
• Thalidomide‐prednisone maintenance following autologous stem cell transplant for Multiple Myeloma: effect on thrombin generation and procoagulant markers in NCIC CTG MY.10  Journal Articles
• The N-terminal domain of antithrombin-III is essential for heparin binding and complex-formation with, but not cleavage by, α-thrombin  Journal Articles
• The Additive Effect of Low Molecular Weight Heparins on Thrombin Inhibition by Dermatan Sulfate  Journal Articles
• The Antithrombotic Properties of Human Prothrombin Fragment 1.2 in Mice  Journal Articles
• The Asp272–Glu282 Region of Platelet Glycoprotein Ibα Interacts with the Heparin-binding Site of α-Thrombin and Protects the Enzyme from the Heparin-catalyzed Inhibition by Antithrombin III  Journal Articles
• The Binding of Unfractionated Heparin and Low Molecular Weight Heparin to Thrombin-Activated Human Endothelial Cells  Journal Articles
• The Clearance of Thrombin-antithrombin and Related Serpin-enzyme Complexes from the Circulation: Role of Various Hepatocyte Receptors  Journal Articles
• The Cleaved Peptide of PAR1 Results in a Redistribution of the Platelet Surface GPIb-IX-V Complex to the Surface-Connected Canalicular System  Journal Articles
• The Coagulation System in Humans  Journal Articles
• The Effect of Antithrombin III-Independent Thrombin Inhibitors and Heparin on Fibrin Accretion onto Fibrin-Coated Polyethylene \textbar Request PDF  Journal Articles
• The Effect of Heparin Adsorbed on Sepharose-Lysine on the Inactivation of Thrombin by Anti-Thrombin III  Journal Articles
• The Effect of Pretreatment of Human or Rabbit Platelets With Chymotrypsin on Their Responses to Human Fibrinogen and  Other
• The Effect of Thrombin Inhibitors on Tissue Plasminogen Activator Induced Thrombolysis in a Rat Model  Journal Articles
• The Effect of Thrombin on Platelet Accumulation on the Vessel Wall - Influence of Heparin and Aspirin  Journal Articles
• The Effects of Hormone Replacement Therapy on Thrombin Generation, Fibrinolysis Inhibition, and Resistance to Activated Protein C  Journal Articles
• The Effects of Steroids on Coagulation Dysfunction Induced by Cardiopulmonary Bypass: A Steroids in Cardiac Surgery (SIRS) Trial Substudy  Journal Articles
• The King is Dead (Warfarin): Direct Thrombin and Factor Xa Inhibitors: The Next Diadochian War?  Journal Articles
• The Molecular Pathology of Inherited Human Antithrombin III Deficiency  Journal Articles
• The Non-Vitamin K Antagonist Oral Anticoagulants in Heart Disease: Section V—Special Situations  Journal Articles
• The Oral Thrombin Inhibitor Dabigatran: Strengths and Weaknesses  Journal Articles
• The Pathogenesis of Venous Limb Gangrene Associated with Heparin-Induced Thrombocytopenia  Journal Articles
• The Pathophysiology of Heparin-Induced Thrombocytopenia  Journal Articles
• The Roles of Selected Arginine and Lysine Residues of TAFI (Pro-CPU) in Its Activation to TAFIa by the Thrombin-Thrombomodulin Complex  Journal Articles
• The Structural Integrity of Anion Binding Exosite I of Thrombin Is Required and Sufficient for Timely Cleavage and Activation of Factor V and Factor VIII  Journal Articles
• The Transferable Tail:  Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α₁-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition  Journal Articles
• The absence of `minor' risk factors for recurrent venous thromboembolism: a systematic review of negative predictive values and negative likelihood ratios  Journal Articles
• The affinity of human, rabbit and bovine thrombins for sepharose-lysine and other conjugates  Journal Articles
• The appended tail region of heparin cofactor II and additional reactive centre loop mutations combine to increase the reactivity and specificity of α1-proteinase inhibitor M358R for thrombin  Journal Articles
• The beginning of the end of warfarin?  Journal Articles
• The benefit-to-risk profile of melagatran is superior to that of hirudin in a rabbit arterial thrombosis prevention and bleeding model  Journal Articles
• The blood compatibility challenge. Part 1: Blood-contacting medical devices: The scope of the problem  Journal Articles
• The blood platelet as a model for regulating blood coagulation on cell surfaces and its consequences.  Journal Articles
• The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal‐based and cell‐based models  Journal Articles
• The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand  Journal Articles
• The decrease in phosphatidylinositol 4,5-bisphosphate in ADP-stimulated washed rabbit platelets is not primarily due to phospholipase C activation  Journal Articles
• The direct thrombin inhibitor hirudin  Journal Articles
• The effect of aggregating agents on oxidative metabolism of rabbit platelets  Other
• The effect of glucose on the platelet response to release-inducing stimuli  Other
• The effect of prostaglandin E1 on platelet function in vitro and in vivo  Journal Articles
• The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces  Journal Articles
• The evolving role of direct thrombin inhibitors in acute coronary syndromes  Journal Articles
• The evolving role of direct thrombin inhibitors in acute coronary syndromes.  Journal Articles
• The hypercoagulable state in cancer patients  Journal Articles
• The hypersensitivity to thrombin of platelets from diabetic rats is not due to increased thrombin binding  Journal Articles
• The impact of the endothelial protein C receptor on thrombin generation and clot lysis  Journal Articles
• The importance of thrombin inhibition for the expression of the anticoagulant activities of heparin, dermatan sulphate, low molecular weight heparin and pentosan polysulphate  Journal Articles
• The inactivation of thrombin and plasmin by antithrombin III in the presence of Sepharose-heparin  Journal Articles
• The influence of heparin, NaCl and CaCl2 on the rate of the thrombin-antithrombin III reaction  Journal Articles
• The inhibition by heparin of the intrinsic pathway activation of factor X in the absence of antithrombin-III  Journal Articles
• The inhibition of the anticoagulant activity of heparin by platelets, brain phospholipids, and tissue factor  Journal Articles
• The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin  Journal Articles
• The inhibitory effects of exogenous arachidonic acid on rabbit platelet aggregation and the release reaction  Journal Articles
• The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase  Journal Articles
• The plasma concentration of activated protein C appears normal in patients with haemophilia  Journal Articles
• The plasma proteases, thrombin and plasmin, degrade the proteoglycan of rabbit aorta segments in vitro: an integrated ultrastructural and biochemical study.  Journal Articles
• The presence of plasma proteins facilitates the uptake of 125I-thrombin by the rabbit thoracic aorta endothelium  Journal Articles
• The proteolytic action of Arvin on human fibrinogen  Journal Articles
• The relative importance of thrombin inhibition and factor Xa inhibition to the antithrombotic effects of heparin  Journal Articles
• The status of new anticoagulants  Journal Articles
• The thrombogenicity of prothrombin complex concentrates: I. The relationship between characteristics and thrombogenicity in rabbits  Journal Articles
• Think of HIT  Journal Articles
• Thrombin Binds to Soluble Fibrin Degradation Products Where it Is Protected From Inhibition by Heparin-Antithrombin but Susceptible to Inactivation by Antithrombin-Independent Inhibitors  Journal Articles
• Thrombin Generation  Journal Articles
• Thrombin Generation and Presence of Thrombin Receptor in Ovarian Follicles1  Journal Articles
• Thrombin Generation during Cardiac Surgery: Is Heparin the Ideal Anticoagulant?  Journal Articles
• Thrombin Generation in Newborn Plasma Is Critically Dependent on the Concentration of Prothrombin  Journal Articles
• Thrombin Inhibition Is Impaired in Plasma of Sick Neonates  Journal Articles
• Thrombin Inhibition by Hirudin: How Hirudin Inhibits Thrombin  Journal Articles
• Thrombin Regulation in Children Differs from Adults in the Absence and Presence of Heparin  Journal Articles
• Thrombin Regulation in Mother and Fetus During Pregnancy  Journal Articles
• Thrombin activation rate constant: One-stage chromogenic assay for the extrinsic system  Journal Articles
• Thrombin and Antithrombotics  Journal Articles
• Thrombin as an adjuvant to reanastomosis of the fallopian tubes reduces implantations in the rabbit.  Journal Articles
• Thrombin binding to platelets and their activation in plasma  Journal Articles
• Thrombin binding to platelets from hypercholesterolaemic rats  Journal Articles
• Thrombin generation in vitro in the presence of by‐passing agents in siblings with severe haemophilia A  Journal Articles
• Thrombin generation abnormalities in Quebec platelet disorder  Journal Articles
• Thrombin generation abnormalities in commonly encountered platelet function disorders  Journal Articles
• Thrombin generation after the abrupt cessation of intravenous unfractionated heparin among patients with acute coronary syndromes  Journal Articles
• Thrombin generation and bleeding in cardiac surgery: a clinical narrative review  Journal Articles
• Thrombin generation and fibrin formation following injury to rabbit neointima. Studies of vessel wall reactivity and platelet survival  Other
• Thrombin generation, ProC(®)Global, prothrombin time and activated partial thromboplastin time in thawed plasma stored for seven days and after methylene blue/light pathogen inactivation.  Journal Articles
• Thrombin generation, bleeding and hemostasis in humans: Protocol for a scoping review of the literature  Journal Articles
• Thrombin structure and function  Journal Articles
• Thrombin-induced inositol phosphate production by platelets from rats with diet-induced or genetically determined hypercholesterolemia.  Journal Articles
• Thrombin-induced inositol trisphosphate production by rabbit platelets is inhibited by ethanol  Journal Articles
• Thrombocytopenia in Preeclampsia and Eclampsia  Journal Articles
• Thrombocytopenia in septicemia: the role of disseminated intravascular coagulation  Journal Articles
• Thromboepidemiology: Identifying patients with heritable risk for thrombin-mediated thromboembolic events  Journal Articles
• Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome  Journal Articles
• Thrombotic characteristics of extracellular vesicles derived from prostate cancer cells  Journal Articles
• Ticlopidine Facilitates the Deaggregation of Human Platelets Aggregated by Thrombin \textbar Request PDF  Other
• Tissue factor microparticles and haemophilia  Journal Articles
• Tumorkrankheit, Thromboembolien und antithrombotische Therapie: Gibt es ein Antikoagulans der Wahl?  Journal Articles
• U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets.  Journal Articles
• Uncontrolled PGI2 production by whole vessel wall segments due to thrombin generation and its prevention by heparin  Journal Articles
• Understanding Thrombin and Hemostasis  Journal Articles
• Unexpected Effects of Aurin Tricarboxylic Acid on Human Platelets  Journal Articles
• Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa  Journal Articles
• Update on platelet procoagulant mechanisms in health and in bleeding disorders  Journal Articles
• Uptake and Catabolism of 125l-Thrombin by the Rabbit Thoracic Aorta In Vitro: Permeability of the Endothelium, Intima-Media and Adventitial Layers  Journal Articles
• Urokinase has direct catalytic activity against fibrinogen and renders it less clottable by thrombin.  Journal Articles
• Use of Hirulog in the prevention of venous thrombosis after major hip or knee surgery.  Journal Articles
• Venous Limb Gangrene during Warfarin Treatment of Cancer-Associated Deep Venous Thrombosis  Journal Articles
• Venous and arterial thrombosis – pathogenesis and the rationale for anticoagulation  Journal Articles
• Venous limb gangrene during overlapping therapy with warfarin and a direct thrombin inhibitor for immune heparin‐induced thrombocytopenia  Journal Articles
• Venous thromboembolism management: where do novel anticoagulants fit?  Journal Articles
• Vimentin Exposed on Activated Platelets and Platelet Microparticles Localizes Vitronectin and Plasminogen Activator Inhibitor Complexes on Their Surface  Journal Articles
• Volutrauma activates the clotting cascade in the newborn but not adult rat  Journal Articles
• Von Willebrand factor and thrombin activation in children with newly diagnosed acute lymphoblastic leukemia: An impact of peripheral blasts  Journal Articles
• Withdrawal of warfarin after deep vein thrombosis  Journal Articles
• Ximelagatran or Warfarin for Stroke Prevention in Patients With Atrial Fibrillation?  Journal Articles
• Zinc promotes clot stability by accelerating clot formation and modifying fibrin structure  Journal Articles
• α2-Macroglobulin Remains as Important as Antithrombin III for Thrombin Regulation in Cord Plasma in the Presence of Endothelial Cell Surfaces  Journal Articles
• γT‐S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo  Journal Articles