Journal article
Antithrombin-Heparin Covalent Complex
Abstract
BACKGROUND: The anticoagulant effect of heparinoids is attributed to their cofactor activity for antithrombin (AT) and heparin cofactor II. In patients with thrombosis, however, thrombin is often protected from AT-dependent, heparin-mediated inactivation. The purpose of this study was to compare the properties of unfractionated/standard heparin (UFH/SH) and those of a novel covalent AT-heparin complex (ATH) in a rabbit arterial thrombosis …
Authors
Chan AKC; Rak J; Berry L; Liao P; Vlasin M; Weitz J; Klement P
Journal
Circulation, Vol. 106, No. 2, pp. 261–265
Publisher
Wolters Kluwer
Publication Date
July 9, 2002
DOI
10.1161/01.cir.0000021431.88095.78
ISSN
0009-7322