Tissue factor microparticles and haemophilia

Abstract

Treatment choices for haemophilia patients with inhibitors are suboptimal. Tissue factor-bearing microparticles home to thrombi in a cell adhesion molecule-dependent fashion. Their potential utility as a procoagulant is discussed along with the challenges of evaluating this approach in mouse models of haemophilia.

Authors

Gross PL; Vaezzadeh N

Journal

Thrombosis Research, Vol. 125, , pp. s67–s69

Publisher

Elsevier

Publication Date

April 1, 2010

DOI

10.1016/j.thromres.2010.01.041

ISSN

0049-3848

Associated Experts

Peter Lawrence Gross

Associate Professor (Part-Time), Faculty of Health Sciences

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