Tissue factor microparticles and haemophilia Journal Articles

abstract

• Treatment choices for haemophilia patients with inhibitors are suboptimal. Tissue factor-bearing microparticles home to thrombi in a cell adhesion molecule-dependent fashion. Their potential utility as a procoagulant is discussed along with the challenges of evaluating this approach in mouse models of haemophilia.

authors

• Gross, Peter Lawrence
• Vaezzadeh, Nima

status

• published 

publication date

• April 2010

has subject area

• 1103 Clinical Sciences (FoR)
• Animals (MeSH)
• Bone Marrow (MeSH)
• Cardiovascular System & Hematology (Science Metrix)
• Cell-Derived Microparticles (MeSH)
• Endothelium, Vascular (MeSH)
• Hemophilia A (MeSH)
• Hemostasis (MeSH)
• Humans (MeSH)
• Leukocytes (MeSH)
• Membrane Glycoproteins (MeSH)
• Mice (MeSH)
• Mice, Transgenic (MeSH)
• Models, Biological (MeSH)
• Thrombin (MeSH)
• Thromboplastin (MeSH)

published in

• Thrombosis Research  Journal

keywords

• Animals
• Bone Marrow
• Cell-Derived Microparticles
• Endothelium, Vascular
• Hemophilia A
• Hemostasis
• Humans
• Leukocytes
• Membrane Glycoproteins
• Mice
• Mice, Transgenic
• Models, Biological
• Thrombin
• Thromboplastin

Digital Object Identifier (DOI)

• 10.1016/j.thromres.2010.01.041

PubMed ID

• 20171716

start page

• S67

end page

• S69

volume

• 125