Journal article
The Effects of Hormone Replacement Therapy on Thrombin Generation, Fibrinolysis Inhibition, and Resistance to Activated Protein C Prospective Cohort Study and Review of the Literature
Abstract
Recent studies have found that hormone replacement therapy (HRT) is associated with a two- to fourfold increased risk of venous thromboembolism, but the thrombogenic mechanism of HRT remains unclear. To investigate whether HRT use induces a procoagulant state, we undertook a prospective cohort study in postmenopausal women to investigate the effects of 3 months of treatment with oral HRT (conjugated equine estrogen 0.625 mg daily and …
Authors
Douketis JD; Gordon M; Johnston M; Julian JA; Adachi JR; Ginsberg JS
Journal
Thrombosis Research, Vol. 99, No. 1, pp. 25–34
Publisher
Elsevier
Publication Date
July 2000
DOI
10.1016/s0049-3848(00)00217-6
ISSN
0049-3848
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Activated Protein C ResistanceAdministration, OralAntithrombin IIICohort StudiesFemaleFibrinolysisFollow-Up StudiesHormone Replacement TherapyHumansPeptide FragmentsPeptide HydrolasesPlasminogen Activator Inhibitor 1PostmenopauseProspective StudiesProthrombinThrombinThrombophlebitisVenous Thrombosis