Journal article
Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms
Abstract
OBJECTIVE: Activation of neutrophils by microbial or inflammatory stimuli results in the release of neutrophil extracellular traps (NETs) that are composed of DNA, histones, and antimicrobial proteins. In purified systems, cell-free DNA (CFDNA) activates the intrinsic pathway of coagulation, whereas histones promote thrombin generation through platelet-dependent mechanisms. However, the overall procoagulant effects of CFDNA/histone complexes as …
Authors
Gould TJ; Vu TT; Swystun LL; Dwivedi DJ; Mai SHC; Weitz JI; Liaw PC
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 34, No. 9, pp. 1977–1984
Publisher
Wolters Kluwer
Publication Date
September 2014
DOI
10.1161/atvbaha.114.304114
ISSN
1079-5642