Activation of blood coagulation by plaque rupture: Mechanisms and prevention

Inhibition of thrombosis is proving to be an important treatment goal in many clinical situations, including coronary thrombolysis, angioplasty, and unstable angina. Heparin is a potent inhibitor of thrombin and thrombin generation, but its ability to accelerate thrombolysis, prevent acute reocclusion after vascular injury in angioplasty, and prevent myocardial infarction in unstable angina is relatively limited, possibly because clot-bound …