Journal article
The Additive Effect of Low Molecular Weight Heparins on Thrombin Inhibition by Dermatan Sulfate
Abstract
The aim of this study was to investigate the mechanism by which the anticoagulant activity of dermatan sulfate (DS) is increased by low molecular weight heparin (LMWH). In platelet poor plasma, LMWH enhances the effect of DS on thrombin (IIa) inhibition as determined by thrombin clotting times and with a chromogenic substrate assay. Analysis of the results of the chromogenic assays using either the algebraic fractional or the graphic isobole …
Authors
Cosmi B; Agnelli G; Young E; Hirsh J; Weitz J
Journal
Thrombosis and Haemostasis, Vol. 70, No. 03, pp. 443–447
Publisher
Thieme
Publication Date
1993
DOI
10.1055/s-0038-1649602
ISSN
0340-6245