Journal article
Bioregulatory roles for fibrin(ogen) on blood coagulation
Abstract
A high plasma fibrin(ogen) concentration is a known risk for thrombosis and cardiovascular disease. Because fibrin(ogen) binds alpha-thrombin with high affinity, it has potential to modulate the interactions of the enzyme with its inhibitors and other substrates in plasma. In particular, fibrin moderates the inhibition of thrombin by antithrombin III and antithrombin III/heparin. Recently, we have demonstrated a novel regulatory role for …
Authors
Okwusidi JI; Ofosu FA
Journal
Medical Hypotheses, Vol. 39, No. 2, pp. 152–155
Publisher
Elsevier
Publication Date
October 1992
DOI
10.1016/0306-9877(92)90177-e
ISSN
0306-9877