Journal article
Mechanism of inhibition of the prothrombinase complex by a covalent antithrombin–heparin complex
Abstract
Factor-Xa assembly into the prothrombinase complex decreases its availability for inhibition by antithrombin + unfractionated heparin (AT + UFH). We have developed a novel covalent antithrombin-heparin complex (ATH), with enhanced anticoagulant actions compared with AT + UFH. The present study was performed to extend understanding of the anticoagulant mechanisms of ATH by determining its inhibition of Xa within the critical prothrombinase. …
Authors
Stevic I; Berry LR; Chan AKC
Journal
The Journal of Biochemistry, Vol. 152, No. 2, pp. 139–148
Publisher
Oxford University Press (OUP)
Publication Date
August 1, 2012
DOI
10.1093/jb/mvs039
ISSN
0021-924X