Journal article
Heparin sensitivity and resistance in the neonate: An explanation
Abstract
Based on in vitro tests, newborns are reported to be both sensitive and resistant to standard heparin (SH) compared to adults. The sensitivity to SH occurs in assays based on de novo thrombin generation, and SH resistance occurs in systems where exogenous thrombin is added to newborn plasma. We hypothesized that this apparent paradox is related to the antithrombin III to (pro) thrombin ratio associated with each test. Since SH catalyses the …
Authors
Vieira A; Berry L; Ofosu F; Andrew M
Journal
Thrombosis Research, Vol. 63, No. 1, pp. 85–98
Publisher
Elsevier
Publication Date
July 1991
DOI
10.1016/0049-3848(91)90272-x
ISSN
0049-3848