Journal article
Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients
Abstract
Although thromboembolism is a problematic complication of chemotherapy, the pathogenic mechanisms by which chemotherapeutic agents exert prothrombotic effects in vivo are unclear.The objective of this study was to examine the effects of adjuvant chemotherapy on thrombin generation, the protein C anticoagulant pathway, and microparticle tissue factor (MP TF) activity in 26 breast cancer patients (stages I to III). The patients received …
Authors
Mukherjee SD; Swystun LL; Mackman N; Wang J-G; Pond G; Levine MN; Liaw PC
Journal
Pathophysiology of Haemostasis and Thrombosis, Vol. 37, No. 2-4, pp. 88–97
Publisher
Karger Publishers
Publication Date
2010
DOI
10.1159/000324166
ISSN
1424-8832
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAntigens, CDAntineoplastic Combined Chemotherapy ProtocolsAntithrombin IIIBreast NeoplasmsCyclophosphamideDoxorubicinEndothelial Protein C ReceptorEpirubicinFemaleFluorouracilHumansMiddle AgedNeoplasm StagingPeptide HydrolasesProtein CReceptors, Cell SurfaceThrombinThrombomodulinThromboplastinThrombosisTime Factors