Journal article
Heparin and Low Molecular Weight Heparins Inhibit Prothrombinase Formation but not its Activity in Plasma
Abstract
Factor V activation is a critical step preceding prothrombinase formation. This study determined the contributions of factor Xa and thrombin, which activate purified factor V with similar catalytic efficiency, to plasma factor V activation during coagulation. Prothrombin activation began without a lag phase after a suspension of coagulant phospholipids, CaCl2, and factor Xa was added to factor X-depleted plasma. Hirudin, a potent thrombin …
Authors
Ofosu FA; Lormeau JC; Craven S; Dewar L; Anvari N
Journal
Thrombosis and Haemostasis, Vol. 72, No. 06, pp. 862–868
Publisher
Thieme
Publication Date
1994
DOI
10.1055/s-0038-1648975
ISSN
0340-6245