Journal article
The relative importance of thrombin inhibition and factor Xa inhibition to the antithrombotic effects of heparin.
Abstract
The relative importance of antithrombin and anti-factor Xa activities of heparin fractions required to achieve optimal antithrombotic effects is unknown. To study this, we measured the effects of standard heparin, an octasaccharide heparin fraction (anti-factor Xa activity only), and dermatan sulfate (antithrombin activity only) on the prevention of thrombosis and related this to their anticoagulant effects in vivo in rabbits. Thrombosis was …
Authors
Buchanan MR; Boneu B; Ofosu F; Hirsh J
Journal
Blood, Vol. 65, No. 1, pp. 198–201
Publisher
American Society of Hematology
Publication Date
January 1, 1985
DOI
10.1182/blood.v65.1.198.bloodjournal651198
ISSN
0006-4971