Contrasting Effects of Thrombin and the Thrombin Receptor Peptide, SFLLRN, on Aggregation and Release of 14C-Serotonin by Human Platelets Pretreated with Chymotrypsin or Serratia marcescens Protease

Download Citation on ResearchGate \textbar Contrasting Effects of Thrombin and the Thrombin Receptor Peptide, SFLLRN, on Aggregation and Release of 14C-Serotonin by Human Platelets Pretreated with Chymotrypsin or Serratia marcescens Protease \textbar Chymotrypsin cleaves glycoprotein Ib (GPIb) on platelets and reduces their responsiveness to thrombin; platelets from patients with the Bernard-Soulier syndrome, which lack GPIb, are also less responsive to thrombin than platelets from normal donors. However, Bernard-Soulier... \vphantom