Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein Academic Article uri icon

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abstract

  • Key Points Mice deficient in HRG have normal hemostasis, but demonstrate accelerated thrombosis via the contact system. HRG abrogates nucleic acid–driven coagulation and serves as a novel modulator of the contact system in vivo.

authors

  • Vu, Trang T
  • Zhou, Ji
  • Leslie, Beverly A
  • Stafford, Alan R
  • Fredenburgh, James C
  • Ni, Ran
  • Qiao, Shengjun
  • Vaezzadeh, Nima
  • Jahnen-Dechent, Willi
  • Monia, Brett P
  • Gross, Peter Lawrence
  • Weitz, Jeffrey

publication date

  • April 23, 2015

published in