Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein Journal Articles

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abstract

Key PointsMice deficient in HRG have normal hemostasis, but demonstrate accelerated thrombosis via the contact system. HRG abrogates nucleic acid–driven coagulation and serves as a novel modulator of the contact system in vivo.

authors

Vu, Trang T
Zhou, Ji
Leslie, Beverly A
Stafford, Alan R
Fredenburgh, James C
Ni, Ran
Qiao, Shengjun
Vaezzadeh, Nima
Jahnen-Dechent, Willi
Monia, Brett P
Gross, Peter Lawrence
Weitz, Jeffrey

status

published

publication date

April 23, 2015

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Animals (MeSH)
Blood Coagulation (MeSH)
Chlorides (MeSH)
Factor XII (MeSH)
Female (MeSH)
Ferric Compounds (MeSH)
Gene Deletion (MeSH)
Gene Knockdown Techniques (MeSH)
Hemostasis (MeSH)
Immunology (Science Metrix)
Mice (MeSH)
Mice, Inbred C57BL (MeSH)
Proteins (MeSH)
Thrombin (MeSH)
Thrombosis (MeSH)

published in

Blood Journal