Journal article
The decrease in phosphatidylinositol 4,5-bisphosphate in ADP-stimulated washed rabbit platelets is not primarily due to phospholipase C activation
Abstract
Addition of 10 micron-ADP to washed rabbit platelets caused platelet shape change and aggregation without release of the contents of the amine-storage granules, and caused a transient decrease (8.8% at 10 s) in the amount of phosphatidylinositol 4,5-bisphosphate (PIP2). By 20 s the decrease in PIP2 was no longer apparent, but by 60 s the amount of PIP2 was again decreased. Addition of thrombin (1 unit/ml), which causes platelet shape change, …
Authors
Vickers JD; Kinlough-Rathbone RL; Mustard JF
Journal
Biochemical Journal, Vol. 237, No. 2, pp. 327–332
Publisher
Portland Press
Publication Date
July 15, 1986
DOI
10.1042/bj2370327
ISSN
0264-6021