Journal article
Radiolabeled r-Hirudin as a Measure of Thrombin Activity at, or within, the Rabbit Aorta Wall In Vitro and In Vivo
Abstract
The behavior of 125I-labeled recombinant hirudin towards the uninjured and de-endothelialized rabbit aorta wall has been studied in vitro and in vivo to determine its usefulness as an indicator of thrombin activity associated with the aorta wall. Thrombin adsorbed to either sulfopropyl-Sephadex or heparin-Sepharose bound > 95% of 125I-r-hirudin and the complex remained bound to the matrix. Binding of 125I-r-hirudin to the exposed aorta …
Authors
Hatton MWC; Ross-Ouellet B
Journal
Thrombosis and Haemostasis, Vol. 71, No. 04, pp. 499–506
Publisher
Thieme
Publication Date
1994
DOI
10.1055/s-0038-1642467
ISSN
0340-6245