Journal article
The Effects of Steroids on Coagulation Dysfunction Induced by Cardiopulmonary Bypass: A Steroids in Cardiac Surgery (SIRS) Trial Substudy
Abstract
Cardiopulmonary bypass (CPB) surgery, despite heparin administration, elicits activation of coagulation system resulting in coagulopathy. Anti-inflammatory effects of steroid treatment have been demonstrated, but its effects on coagulation system are unknown. The primary objective of this study is to assess the effects of methylprednisolone on coagulation function by evaluating thrombin generation, fibrinolysis, and platelet activation in …
Authors
Paparella D; Parolari A; Rotunno C; Vincent J; Myasoedova V; Guida P; De Palo M; Margari V; Devereaux PJ; Lamy A
Journal
Seminars in Thoracic and Cardiovascular Surgery, Vol. 29, No. 1, pp. 35–44
Publisher
Elsevier
Publication Date
2017
DOI
10.1053/j.semtcvs.2017.01.007
ISSN
1043-0679
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Administration, IntravenousAgedAged, 80 and overBiomarkersBlood CoagulationBlood Coagulation TestsBlood Loss, SurgicalCardiac Surgical ProceduresCardiopulmonary BypassDouble-Blind MethodDrug Administration ScheduleFemaleFibrinolysisGlucocorticoidsHumansItalyMaleMethylprednisoloneMiddle AgedOntarioPlatelet ActivationPlatelet Function TestsPostoperative HemorrhageRisk FactorsThrombinTime FactorsTreatment Outcome