Journal article
Thrombin generation abnormalities in Quebec platelet disorder
Abstract
INTRODUCTION: Calibrated automated thrombograms (CAT) with platelet-poor (PPP) and platelet-rich plasma (PRP) have provided useful insights on bleeding disorders. We used CAT to assess thrombin generation (TG) in Quebec platelet disorder (QPD)-a bleeding disorder caused by a PLAU duplication mutation that increases platelet (but not plasma) urokinase plasminogen activator (uPA), leading to intraplatelet (but not systemic) plasmin generation …
Authors
Brunet JG; Sharma T; Tasneem S; Liang M; Wilson MD; Rivard GE; Hayward CPM
Journal
International Journal of Laboratory Hematology, Vol. 42, No. 6, pp. 801–809
Publisher
Wiley
Publication Date
December 2020
DOI
10.1111/ijlh.13302
ISSN
1751-5521