Comparative effects of heparin and LMW heparin on hemostasis Conferences

abstract

• We performed studies to investigate the effect of protamine sulfate neutralization on both the anticoagulant and hemostatic effects of enoxaparin and heparin. Although the anti-Factor Xa effect of enoxaparin was incompletely neutralized by protamine sulfate in an experimental animal model, protamine sulfate reversed bleeding induced by hemorrhagic doses of enoxaparin.

authors

• Hirsh, Jack
• Buchanan, Michael R

status

• published 

publication date

• January 1991

has subject area

• 1103 Clinical Sciences (FoR)
• Animals (MeSH)
• Antithrombin III (MeSH)
• Blood Coagulation Factors (MeSH)
• Cardiovascular System & Hematology (Science Metrix)
• Ear (MeSH)
• Enzyme Activation (MeSH)
• Hemorrhage (MeSH)
• Hemostasis (MeSH)
• Heparin (MeSH)
• Heparin Antagonists (MeSH)
• Heparin, Low-Molecular-Weight (MeSH)
• Oligosaccharides (MeSH)
• Protamines (MeSH)
• Protein Binding (MeSH)
• Protein Conformation (MeSH)
• Rabbits (MeSH)
• Thrombin (MeSH)
• Wounds, Stab (MeSH)

published in

• Thrombosis Research  Journal

keywords

• Animals
• Antithrombin III
• Blood Coagulation Factors
• Ear
• Enzyme Activation
• Hemorrhage
• Hemostasis
• Heparin
• Heparin Antagonists
• Heparin, Low-Molecular-Weight
• Oligosaccharides
• Protamines
• Protein Binding
• Protein Conformation
• Rabbits
• Thrombin
• Wounds, Stab

Digital Object Identifier (DOI)

• 10.1016/0049-3848(91)90399-h

PubMed ID

• 1658966

start page

• 11

end page

• 17

volume

• 61

issue

• SUPPL. 2